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Exceptionally Preserved Cambrian Trilobite Digestive System Revealed in 3D by Synchrotron-Radiation X-Ray Tomographic Microscopy.

The Cambrian 'Orsten' fauna comprises exceptionally preserved and phosphatised microscopic arthropods. The external morphology of these fossils is well known, but their internal soft-tissue anatomy has remained virtually unknown. Here, we report the first non-biomineralised tissues from a juvenile polymerid trilobite, represented by digestive structures, glands, and connective strands harboured in

Human adipose cells in vitro are either refractory or responsive to insulin, reflecting host metabolic state.

While intercellular communication processes are frequently characterized by switch-like transitions, the endocrine system, including the adipose tissue response to insulin, has been characterized by graded responses. Yet here individual cells from adipose tissue biopsies are best described by a switch-like transition between the basal and insulin-stimulated states for the trafficking of the glucos

Heterozygosity for a coding SNP in COL1A2 confers a lower BMD and an increased stroke risk

Genetic variation plays ail important role in osteoporosis and a prime candidate gene is Collagen alpha2(I) (COL1A2). A coding polymorphism (rs42524) in COL1A2 has previously been associated with intracranial aneurysms. Here the effects of this polymorphism have been Studied in relation to bone mineral density (BMD) and prevalences of stroke and myocardial infarction (MI). rs42524 was genotyped in

Mean radiant temperature – A predictor of heat related mortality

Abstract Health studies have repeatedly used air temperature (Ta), sometimes adjusted for humidity, when analyzing the impact of weather on mortality. The aim of this study is to highlight the importance of mean radiant temperature (Tmrt) and its impact on heat related mortality. Tmrt is an essential meteorological parameter that influences the thermal comfort (heat load) of humans. It is useful w

Antidiabetic Actions of an Estrogen Receptor beta Selective Agonist

The estrogen receptor beta (ER beta) is emerging as an important player in the physiology of the endocrine pancreas. We evaluated the role and antidiabetic actions of the ER beta selective agonist WAY200070 as an insulinotropic molecule. We demonstrate that WAY200070 enhances glucose-stimulated insulin secretion both in mouse and human islets. In vivo experiments showed that a single administratio

Basal Plasma Levels of Copeptin are Elevated in Inactive Inflammatory Bowel Disease after Bowel Resection.

Evidence of interactions between the enteric nervous system, neuropeptides, and the immune system is growing. The aim of this study was to examine basal plasma levels of a variety of peptide precursors in patients with inflammatory bowel disease (IBD). In two middle-aged cohorts, Malmö Preventive Medicine (n = 5,415) and Malmö Diet and Cost Study (n = 6,103), individuals with the diagnosis of IBD

Sustainable Public Procurement and the Single Market – is there a conflict of interest?

Sustainable public procurement indicates that procurement is about more than just saving money. Other important interests such as social and environmental considerations can be promoted through public procurement. Thus, the Member States may use their purchasing power to procure goods and services that foster innovation, respect the environment and combat climate change while improving employment,

Patients' experiences of consultations for nonspecific chronic orofacial pain: A phenomenological study

Aims: To use a qualitative research study to analyze the experiences of patients with nonspecific chronic orofacial pain with respect to consultations for their pain condition. Methods: Fourteen patients (11 women and 3 men; age range, 21 to 77 years) were strategically selected through a purposive sampling of the chronic orofacial pain patients referred to the Orofacial Pain Unit at the Faculty o

The REAL process - a process for recycling sludge from water works

In order to produce drinking water, coagulants - such as aluminium salts - are widely used for precipitation and separation of impurities from raw water. The residual from the process is sludge, which presents a disposal problem. The REAL process is a method for recycling the aluminium from the sludge. In a first step, the aluminium hydroxide is dissolved in sulphuric acid. In a second step, an ul

Kramfors och kampen om livskvaliteten - En diskursanalytisk studie av kommunens marknadsföring

In the era of urbanization and globalization, many small, rural and post-industrial cities struggle for growth. The competition for citizens and visitors is intense, and one commonly used strategy is to promote the city to a target audience. Place marketing, however, is homogenized to a great extent. Marketing thus seems like a useless approach, yet almost every city does it. By using discour

The Process of Europeanization A Study of the European Effects on Polish Domestic Structures

The countries of the European Union are in an ongoing phase of integration. The influences on individual states domestic structures are unquestionable and the governing prerequisites have changed significantly. Poland, a relatively new member state is in the middle of the process and so this study analyses the effects of Europeanization on polishes domestic structures. The study examines four pub-