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Aquaglyceroporins are channels that facilitate the flux of glycerol and water across lipid bilayers. Although structural information is available for several aquaglyceroporins, the details of how water and glycerol selectivity are maintained and how protons are excluded remain elusive. An approach to obtaining data on the hydrogen atom positions is to apply neutron macromolecular crystallography.
Extracellular vesicles (EVs) have been identified as important mediators of cancer metastasis, especially in the establishment of organ-specific metastatic niches. These membranous vesicles secreted by tumor cells release diverse bioactive cargo, including proteins, nucleic acids, and lipids, thereby allowing for intercellular communication and microenvironment modulation. Recent evidence demonstr
Policy institutes such as central banks need accurate forecasts of key measures of economic activity to design stabilization policies that reduce the severity of economic fluctuations. Therefore, this paper develops a kernel ridge regression estimator in a mixed data sampling framework. Kernel ridge regression can handle many predictors with a nonlinear relationship to the target variable. Consequ
The construction industry is an important societal sector and a major consumer of energy. Improved energy efficiency is important for this sector, but energy efficiency at construction sites has so far been under-researched. The aim of this article is to analyse the drivers of and barriers to improved energy efficiency at construction sites, as perceived by professional actors. The peer-reviewed r
The apparition of adaptive immunity in Gnathostomata correlates with the expansion of the E-protein family to encompass E2-2, HEB, and E2A. Within the family, E2-2 and HEB are more closely evolutionarily related but their concerted action in hematopoiesis remains to be explored. Here we show that the combined disruption of E2-2 and HEB results in failure to express the early lymphoid program in Co
Mass media is becoming more and more personalized and despite common ideas it could actually be a good thing. Instead of affecting the actual content of news coverage it might only have an effect on the way in which news are presented. Famous politicians more regularly become symbols and synonyms for their parties or for the government and are being used to create interest in the beginning of arti
Children that are taken care of for institutional care by the social services are unprivileged as a group. When society takes over the parenting role, it forces local governments and other accountable authorities to guarantee these children satisfactory support and good care according to each child's needs. The aim of this thesis is to analyze and discuss problems with implementation in policy
Our purpose with this study was to look at the connection between social capital and integration. Particularly if meetings between people from different cultures can increase social capital and in that way affect integration. We start by identifying the social integration perspective we are going to use through out the study and then we introduce social capital theory as a way of narrowing down th
Trauma is a leading cause of death. There is a great need for training of human factors such as communication and teamwork in trauma teams. The use of simulation in medical education is increasing, and together with learning strategies based on experiential learning theory, it can be a powerful tool in team training. The aviation-based concept of crew resource management, CRM, in which framework c
