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Role of non-coding RNAs in pancreatic beta-cell development and physiology.

The progression of diabetes is accompanied by increasing demand to the beta-cells to produce and secrete more insulin, requiring complex beta-cell adaptations. Functionally-active and ubiquitous non-coding RNAs (ncRNAs) have the capacity to take part in such adaptations as they have been shown to be key regulatory molecules in various biological processes. In the pancreatic islets, the function of

Imaging apolipoprotein AI in vivo

Coronary disease risk increases inversely with high-density lipoprotein (HDL) level. The measurement of the biodistribution and clearance of HDL in vivo, however, has posed a technical challenge. This study presents an approach to the development of a lipoprotein MRI agent by linking gadolinium methanethiosulfonate (Gd[MTS-ADO3A]) to a selective cysteine mutation in position 55 of apo AI, the majo

Adiponutrin: A multimeric plasma protein.

The interest in adiponutrin stems from adiponutrin variant I148M, which is strongly associated to non-alcoholic fatty liver disease. Adiponutrin has to date been considered to be solely an intracellular protein, with a role in lipid metabolism in liver and adipose tissue. However, a physiologically relevant role for adiponutrin has not been found. The aim of this study was to investigate the prese

Quantifying the Family Frailty Effect in Infant and Child Mortality by Using Median Hazard Ratio (MHR)

Most microlevel studies in the social sciences have focused on the impact of different measured variables. While some studies have also dealt with unobserved variation, it has usually only been controlled for to perfect the estimates of the observables. In this article, the authors applied a modified version of a recently developed method designed to quantify the effect of unobserved variation in

A gluten free diet lowers NKG2D and ligand expression in BALB/c and NOD mice.

The interplay between diet and immune-parameters which could affect type 1 diabetes (T1D) pathogenesis is not sufficiently clarified. Intestinal upregulation of the activating receptor NKG2D(CD314) and its ligands is a hallmark of celiac disease (CD). However, the direct effect of gluten on NKG2D expression is not known. We studied, by FACS (lymphoid tissues) and RT-qPCR (intestine and pancreatic

Ranking and characterization of established BMI and lipid associated loci as candidates for gene-environment interactions

Phenotypic variance heterogeneity across genotypes at a single nucleotide polymorphism (SNP) may reflect underlying gene-environment (G×E) or gene-gene interactions. We modeled variance heterogeneity for blood lipids and BMI in up to 44,211 participants and investigated relationships between variance effects (Pv), G×E interaction effects (with smoking and physical activity), and marginal genetic e

Standards, Barriers to Trade and EU Internal Market Rules : Need for a Renewed Approach?

In light of the speedy technological development in society, technical standards are becoming increasingly important. In the early days, the specific tasks delegated to standardization bodies under the New Approach did not attract much political interest. Today, however, politicians and different stakeholders realize that the tasks delegated to the standardization industry are highly important for

Metabolite profiling of obese individuals before and after a one year weight loss program

Objective:We and others have previously characterized changes in circulating metabolite levels following diet-induced weight loss. Our aim was to investigate whether baseline metabolite levels and weight-loss-induced changes in these are predictive of or associated with changes in body mass index (BMI) and metabolic risk traits.Methods:Serum metabolites were analyzed with gas and liquid chromatogr

Viruses, diabetes, and autoimmunity : Studies of subjects at genetic risk for type 1 diabetes

The possible importance of virus infections before the development of islet autoimmunity and then for the appearance of clinical type 1 diabetes is reviewed. There is a lack of specific data on the role of virus to induce islet autoimmunity. There is also a paucity of data to demonstrate that virus infections may contribute to an accelerated disease process resulting in clinical onset of type 1 di

Psykisk ohälsa, radikalisering och terrorism : Inget säkert samband har kunnat påvisas

Tillgängliga forskningsresultat om samband mellan radikalisering, terrorism och psykisk ohälsa kan ännu inte användas som underlag för beslut om ändrade rutiner eller behandlingsmetoder i klinisk psykiatrisk verksamhet. De screening- och riskbedömningsverktyg som finns tillgängliga för kliniskt bruk går inte att använda inom psykiatrin utan att psykiatrins roll i det svenska samhäl-let allvarligt There is little evidence supporting the concept of mental illness as a part of, or reason behind radicalization towards violent extremism and terrorism. There is weak evidence that lone gunmen, particularly those involved in school shootings, may suffer from mental illness to a larger degree than the general population, whereas organized terrorist groups such as jihadists and right-wing extremists

How are biodiversity and dispersal of species affected by the management of roadsides? A systematic map

Background: In many parts of the world, roadsides are regularly managed for traffic-safety reasons. Hence, there are similarities between roadsides and certain other managed habitats, such as wooded pastures and mown or grazed grasslands. These habitats have declined rapidly in Europe during the last century. For many species historically associated with them, roadsides may function as new primary

Online lurking and offline action: young people, social media, and (non-)participation

Research has described political participation as becoming ever more individualised (eg Bennett & Segerberg, 2013). This has been argued to be connected to the general individualisation of society, but also to affordances made possible by new media. One line of research explains political participation combining selective benefits (Olson, 1965), psychological factors (Klandermans & van Ste

Policy learning and smart specialization : Balancing policy change and continuity for new regional industrial paths

This article seeks to explain what policy approaches and policy measures are best suited for promoting new regional industrial path development and what needs and possibilities there are for such policy to change and adapt to new conditions in order to remain efficient. The article departs from the notion of Smart Specialization and discusses how regional strategies that are inspired by this appro

The Cox model is better than the Fine and Gray model when estimating relative revision risks from arthroplasty register data

Background and purpose — Analysis of the revision-free survival of knee and hip prostheses has traditionally been performed using Kaplan–Meier analysis and Cox regression. The competing risk problem that is related to patients who die during follow-up has recently been increasingly discussed, not least with regard to the problem of choosing a suitable statistical method for the analysis. We compar

Knapping Skill and Craft Specialization in Late Neolithic Flint Daggers

The Late Neolithic flint daggers of Scandinavia have long fascinated contemporary flintknappers, due to the beauty of some specimens and the presumed skill required to make them. Examination of populations of daggers in museum collections reveals differences in knapping quality. Such differences are commonly ascribed to variations in skill levels on the part of their makers, and high skill is ofte

Man and Animality in the “Fables” of August Strindberg

The paper focuses on a suite of fable texts from the modern epoch, the “Fables” of August Strindberg, written in the 1880s. In most of these ten prose fables the protagonists are anthropomorphized animals, one of the facts clearly connecting the suite with the Aesopic tradition, which Strindberg was highly familiar with. The basic message of the Aesopic genre – the rejection of man’s animality as

Merging Law and Sociology: Beyond the Dichotomies of Socio-Legal Research

This book brings into question the dichotomies inherent in the sociology of law. It is a journey in search of a method capable of taking us beyond the theoretical limitations imposed on socio-legal research by sharply defined divisions such as “law on the books” and “law in action”, “formal” and “informal law”, “facts” and “norms”, “form” and “substance”, “internal” and “external” legal cultures o