The two monoamines serotonin and melatonin have recently been highlighted as potent regulators of islet hormone secretion and overall glucose homeostasis in the body. In fact, dysregulated signaling of both amines are implicated in β-cell dysfunction and development of type 2 diabetes mellitus (T2DM). Serotonin is a key player in β-cell physiology and plays a role in expansion of β-cell mass. Mela

Förlust av biologisk mångfald är ett av de största hoten mot ekosystem och derasfunktioner. Nästan 500 arter i den marina miljön i Sverige anses idag vara hotade ellersårbara. En av dessa är Sveriges enda val, tumlaren (Phocoena phocoena), som lever längs hela Sveriges kust och rör sig över stora områden i sin jakt på fisk att äta. Mänsklig påverkan, framför allt genom oavsiktliga bifångster vid gThe harbour porpoise (Phocoena phocoena) is a small toothed whale with a mainly coastal distribution in the northern hemisphere. As a marine top predator, the species can act as an indicator for early warning signs of ecosystem changes. At the same time, harbour porpoises are globally threatened by human activities and in need of conservation. Successful protection of harbour porpoises requires un

These days, talk of quantum technologies and the coming “quantum revolution” or “quantum leap” is hard to miss. There is a broad agreement that quantum technologies have a high probability of becoming the next disruptive technological development, and the way they should be regulated and the timing of such intervention are issues that are attracting increasing attention. An analysis of how these q

Introduction: Treatment persistence is a proxy for efficacy, safety and patient satisfaction, and a switch in treatment or treatment discontinuation has been associated with increased indirect and direct costs in inflammatory arthritis (IA). Hence, there are both clinical and economic incentives for the identification of factors associated with treatment persistence. Until now, studies have mainly

Paediatric prospective studies of coeliac disease with longitudinal collection of biological samples and clinical data offer a unique perspective on disease risk. This Review highlights the information now available from international paediatric prospective studies on genetic and environmental risk factors for coeliac disease. In addition, recent omics studies have made it possible to study comple

Multiple language learning has been largely neglected in L2 motivation research. Recently, complexity principles have been used to model multilingual motivation. In this work, multilingual self-guides are conceptualised as emergent from interactions between the motivation systems of different languages. Motivational systems and their emergent properties are also influenced by the contexts in which

Learning a language is a long-term undertaking. In this endeavor, motivation is served by patterns of regulation that steer and control behavior. Regulation can be focused on possibilities and opportunities (an approach pattern), or the implications of failure (an avoidance pattern). Responding to calls for work with a focus on regulation (Papi et al., 2019), and with the aim of developing insight

Demotivation (Dörnyei & Ushioda, 2011) and non-participation (Norton, 2001) characterise negative responses to classroom practice of a generally chronic nature. In this article, focus is directed to negativity that emerges within the context of a particular language developing activity, and which can be understood as a situated response to the activity's demands. In conceptualizing negative re

Novel biomarkers are key to addressing the ongoing pandemic of type 2 diabetes mellitus. While new technologies have improved the potential of identifying such biomarkers, at the same time there is an increasing need for informed prioritization to ensure efficient downstream verification. We have built BALDR, an automated pipeline for biomarker comparison and prioritization in the context of diabe

During WWII, the botanist Hylander (1943, 1949) studied the floristic composition of lawns in 249 landscape gardens mostly in Sweden and concluded that they all harboured multiple, but largely the same, non-native species and genotypes that had most likely been introduced together by the sowing of some im- ported grass seed mix. As demonstrated by the later additions by, for example, Ohlsén (1947)

This paper revisits the glazed redware Scanian jug, brought to the fore by Kulturen archaeologist Anders W. Mårtensson in 1973. Characterized by its faceted base and distinct handle, the jug stands out from its contemporaries. This brief paper presents new chemical data for the Scanian jug, its most common rim forms and a discussion on its area of production. So far, no medieval ceramic production

We are now seeing the development of a new generation of synchrotron radiation sources, the seeded, short-wavelength Free Electron Lasers (FELs), which are capable of driving the radiation to even higher intensities, and with new capabilities such as longitudinal coherence and ultra-short pulses. The Workshop on High-harmonic Seeding for Present and Future Short Wavelength Free-Electron Lasers, ho

Software engineering consists to a large extent of management of information. A qualitative survey on information management in software development companies has been conducted. The survey studies how the companies work with different kinds of documents, which notations are used, quality of the documents etc. The focus is on high-level documents, such as requirements specifications and system tes

This paper draws on the metaphor of ‘magic’ to explore the role of dialogue conferences and subsequent activities as a tool for organizational development and change. It is argued that the magic metaphor is a useful means for critically assessing the role of dialogue conferences in developmental processes, as magic is essentially double-edged in nature. On the one hand, magic is an activity wherei

This paper proposes a system for dynamic speed adaptation in adverse conditions, such as wet/slippery roads, decreased visibility, darkness and sharp curves. Accident risks increase drastically in such conditions, especially since drivers often do not adapt speeds to lower friction or impaired visibility. Thus, the discussion is centred around a method for calculating the appropriate highest speed

Written French is known as a deep orthography, presenting important differences between the spoken and written language systems, especially as far as morphology is concerned. This exploratory study of subject-verb agreement in number illustrates the long and laborious differentiation process of spoken and written French in child learners. The focus of the study is the L2 child, who learns to speak