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Extending the product development process to also include the concurrent design of product and packaging is expected to increase efficiency and effectiveness in the development process. Apart from the obvious advantage of reducing the lead times of the development project, improving environmental impact by reducing the consumption of raw material due to the possibility of facilitating a "tailor ma

This paper examines the major trends unravelling the long-term gender division of family support and care structure that reached its peak in the middle of the twentieth century, often called the “worker-carer” or the “separate spheres” model. The unraveling of the “separate spheres” began with the increase in the labor force participation of married women and continues with the increase in men’s

Road haulage operations and in particular distribution in general, are inefficient. Given the societal importance of road haulage and the low efficiency of the sector, road hauliers need to improve their operations and systematically tackle inefficiencies. However, real causes of these inefficiencies (“root causes”) have not been sufficiently examined in previous studies. This paper aims at expand

Metabolite concentrations reflect the physiological states of tissues and cells. However, the role of metabolic changes in species evolution is currently unknown. Here, we present a study of metabolome evolution conducted in three brain regions and two non-neural tissues from humans, chimpanzees, macaque monkeys, and mice based on over 10,000 hydrophilic compounds. While chimpanzee, macaque, and m

Through genome-wide association meta-analyses of up to 133,010 individuals of European ancestry without diabetes, including individuals newly genotyped using the Metabochip, we have increased the number of confirmed loci influencing glycemic traits to 53, of which 33 also increase type 2 diabetes risk (q < 0.05). Loci influencing fasting insulin concentration showed association with lipid levels a

Intensive agriculture is often bad for wildlife. Does this imply that a goal to boost wildlife on agricultural land is best met through a general reduction in intensity? We argue that such an approach may not be optimal, since cost functions for provision of wildlife on agricultural land may be non-convex, due to fixed costs associated with such provision. This implies that, even when farms are id

Rationale: As support in leading a meaningful and active life, a person with mental illness is often given the opportunity to attend a day centre. However, few studies have investigated the meaningfulness perceived by the person visiting a day centre. For such a purpose, a self-report instrument was developed. Aims: To explore whether perceived meaningfulness, as expressed in the recently develope