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Early Childhood Gut Microbiomes Show Strong Geographic Differences Among Subjects at High Risk for Type 1 Diabetes.
Gut microbiome dysbiosis is associated with numerous diseases, including type 1 diabetes. This pilot study determines how geographical location affects the microbiome of infants at high risk for type 1 diabetes in a population of homogenous HLA class II genotypes.
Chromosome x-wide association study identifies Loci for fasting insulin and height and evidence for incomplete dosage compensation.
The X chromosome (chrX) represents one potential source for the "missing heritability" for complex phenotypes, which thus far has remained underanalyzed in genome-wide association studies (GWAS). Here we demonstrate the benefits of including chrX in GWAS by assessing the contribution of 404,862 chrX SNPs to levels of twelve commonly studied cardiometabolic and anthropometric traits in 19,697 Finni
The IRS1 rs2943641 Variant and Risk of Future Cancer Among Morbidly Obese Individuals.
Circannual variation in blood parasitism in a sub-Saharan migrant passerine bird, the garden warbler
Knowing the natural dynamics of pathogens in migratory birds is important, for example, to understand the factors that influence the transport of pathogens to and their transmission in new geographical areas, whereas the transmission of other pathogens might be restricted to a specific area. We studied haemosporidian blood parasites of the genera Plasmodium, Haemoproteus and Leucocytozoon in a mig
Autosomal dominant cerebellar ataxia with slow ocular saccades, neuropathy and orthostatism: A novel entity?
Anthropometric reference data for elderly Swedes and its disease-related pattern.
Invasive Treatment for Infrainguinal Claudication Has Satisfactory 1 Year Outcome in Three out of Four Patients: A Population-based Analysis from Swedvasc.
The association between the PTPN22 1858C > T variant and type 1 diabetes depends on HLA risk and GAD65 autoantibodies
Completeness and Correctness of Cholecystectomy Data in a National Register--Gallriks.
Lower birth weight indicates higher risk of autistic traits in discordant twin pairs
Background. Autism spectrum disorder (ASD) is a neurodevelopmental disorder of complex etiology. Although strong evidence supports the causal role of genetic factors, environmental risk factors have also been implicated. This study used a co-twin-control design to investigate low birth weight as a risk factor for ASD. Method. We studied a population-based sample of 3715 same-sex twin pairs partici
Pancreatic cancer - cost for overtreatment with gemcitabine.
Gemcitabine has been the standard chemotherapeutic agent in pancreatic cancer. However, two-thirds of pancreatic tumors display low expression of human equilibrative nucleoside transporter 1 (hENT1), which mediates cellular entry of the drug, and do not respond to gemcitabine therapy. The objective was to determine the costs of gemcitabine overtreatment and the cost-effectiveness of hENT1 testing
Risk of Cancer of Unknown Primary after Hospitalization for Autoimmune Diseases.
Ready for OR or not? Human reader supplements Eyesi scoring in cataract surgical skills assessment.
Arguments for a narrow species concept in Rubus sect. Corylifolii
Psychometric properties of the Pediatric Testing Attitudes Scale-Diabetes (P-TAS-D) for parents of children undergoing predictive risk screening
A high quality diet is associated with reduced systemic inflammation in middle-aged individuals.
To examine if overall diet quality is associated with cellular and soluble biomarkers of systemic inflammation in middle-aged individuals.
Health-related quality of life is impaired in active collagenous colitis
Objectives: The characteristic clinical symptoms of collagenous colitis are non-bloody diarrhoea, urgency and abdominal pain. Treatment is aimed at reducing the symptom burden and the disease impact on patients' health-related quality of life. The objective of this study was to analyse health-related quality of life in patients with collagenous colitis. Methods: In a cross-sectional, postal HRQL s