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Huntington's disease (HD) is a hereditary neurodegenerative disorder presenting with chorea, dementia and extensive striatal neuronal death. The mechanism through which the widely expressed mutant huntingtin mediates striatal neurotoxicity is unknown. Excitotoxicity, i.e. calcium-dependent cell death induced by activation of NMDA receptors, has been hypothesized to play an important role in HD. Ou

As a result of the globalisation of the world economy, many enterprises that previously confined their business activities to national markets are now focusing on broader international markets, thus forming the basis for the establishment of global enterprises. In addition to the extension of markets, these global companies also seek cost reductions through scale economics in logistics, marketing,

In this paper, cultural transmission between Slavs and Scandinavians from ca 900 to 1250 is discussed. Cultural identity and identity negotiation through style are topics often studied in higher social strata of societies. Emblemic style is maintained and displayed in jewellery or other eye-catching parts of the material culture to distinguish oneself in relation to others. However, the constructi

The progressive process of tumour invasion and generation of metastases is the primary cause of death for most patients with cancer. Some of the regulatory components of this progressive process are adhesion, migration, and proteolysis. Urokinase -type plasminogen activator (u-PA) is a serine protease associated with tissue remodelling, cellular invasiveness, matrix degradation, angiogenesis, and

E-business is becoming more and more common today. The predictions of future growth give clear indications that companies will use e-business more and more. However in the growth of e-business it has been identified that there is a common lack of understanding in customer needs and logistics. In order to reduce some of this non-understanding this thesis seeks answers to the following question: - H

The general objective of the present thesis work was to examine 3-dimensional structure as well as the motional properties of two different types of two-domain proteins by solution-state NMR. One of the major tasks of this thesis work was to investigate the domain orientation of these molecules by employing residual dipolar couplings (RDC) which can be used as orientational restraints for increasi

This thesis is based on work studying the immunoregulatory mechanisms that govern the balance between activation and inactivation of T lymphocytes. Most of the work has been carried out in an experimental system using a T cell receptor (TCR-Vb3) transgenic mouse strain to obtain a homogenous T-cell population and utilizing the properties of bacterial superantigens to induce T cell responses and un

With a view to the aetiology and treatment of preterm labour and primary dysmenorrhoea we studied the influence of sexual steroids on the plasma levels of oxytocin and vasopressin, effect of these peptides on uterine contractility in vitro and in vivo, receptor concentrations and antagonists to oxytocin and vasopressin. In postmenopausal women oestrogen increased the concentrations in plasma of bo

Pine sawflies (Hymenoptera: Diprionidae) are severe pine defoliators. This thesis investigated sawfly behaviour related to the use of pheromones in integrated pest management, including monitoring with pheromone traps and mating disruption. Neodiprion sertiferr females were placed on pine twigs in the field and 11–30 % of the females that remained on their twig after the first mating re-mated. Onl

AIM: The aim was to evaluate the results of endovascular aneurysm repair (EVAR) of abdominal aortic aneurysms (AAA) in terms of intra-AAA pressure and clinical outcomes. METHODS AND RESULTS: 0.014-inch guide-wire-mounted tip-pressure sensors were used for direct intra-aneurysm sac pressure measurement (DISP) through translumbar puncture of the AAA. Mean Pressure Index was calculated (MPI) as the p

Behaviour of male moths and electrophysiological responses of male pheromone-specific olfactory receptor neurones were studied in two model species, the oriental fruit moth Grapholita molesta and the turnip moth Agrotis segetum. The studies were aimed at elucidating the relative importance of different mating disruption mechanisms. In a wind tunnel study of G. molesta, behavioural response to a r

The red admiral (Vanessa atalanta) is a migratory butterfly that can be found in North America, North Africa, Europe and some parts of Asia. In Europe the main part of the population spend winter in the Mediterranean region and the following spring leave this area to breed further to the north. At least one new generation is then produced in the summer region before they return to the south again

This thesis deals with the fermentation characteristics of lactic acid bacteria (LAB) in oat-based suspensions, with formulation work of fermented products based on oat and with nutritional studies of these products. Changes in structure in terms of viscosity and ropiness were studied when exopolysaccharide (EPS)-producing LAB strains, namely, Lactobacillus delbrueckii subsp. bulgaricus NCFB 2772,