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Screening mammography plays a key role in the early detection of breast cancer, however, estimates of sensitivities (48-88%) and specificities (82-98%) suggest that the diagnostic accuracy can be improved (1, 2, 3). Breast tomosynthesis (BT) is a 3D technique that is expected to improve breast cancer detection compared to screen-film and digital mammography DM). This work presents two clinical obs
Diabetic retinopathy is an ophthalmic complication of diabetes that currently affects 93 million people worldwide. Diabetic macular edema is a subtype of diabetic retinopathy that is characterized by leaking blood vessels in the central part of the retina, and it is a major cause of vision loss in individuals with diabetes. Screening for retinopathy is performed at regular intervals to identify su
Hospital performance is frequently evaluated by analyzing differences between hospital averages in some quality indicators. The results are often expressed as quality charts of hospital variance (e.g., league tables, funnel plots). However, those analyses seldom consider patients heterogeneity around averages, which is of fundamental relevance for a correct evaluation. Therefore, we apply an innov
Introduction Insufficient levels of physical activity are one of the top contributors to global mortality, and it is an important public health priority to increase the proportion of physically active people in the population. The interest in environmental determinants of physical activity has been rapidly increasing over the past few years. However, a majority of the previous literature concerns
Background: Metabolic syndrome (MetS) remains a controversial entity. Specific clusters of MetS components - rather than MetS per se - are associated with accelerated arterial ageing and with cardiovascular (CV) events. To investigate whether the distribution of clusters of MetS components differed cross-culturally, we studied 34,821 subjects from 12 cohorts from 10 European countries and one coho
Background: Asthma genetics has been extensively studied and many genes have been associated with the development or severity of this disease. In contrast, the genetic basis of allergic rhinitis (AR) has not been evaluated as extensively. It is well known that asthma is closely related with AR since a large proportion of individuals with asthma also present symptoms of AR, and patients with AR hav
Cancer is today a major healthcare problem worldwide. There are many forms of cancer, which is a genetic disease, believed to result from a multistep process with genetic and epigenetic changes accumulating over time. Breast cancer is one of the most common forms of cancer in women, while it is much more rare in men. Male breast cancer (MBC) exhibits both similarities and differences with female b
Early reperfusion in the setting of an ST-elevation myocardial infarction (STEMI) is of utmost importance. However, the effects of early versus late reperfusion in this patient group undergoing primary percutaneous coronary intervention (PCI) have so far been inconsistent in previous studies. The purpose of this study was to evaluate in a nationwide cohort the effects of delay from first medical c
Inspired by the works of Michel Foucault and Erling Sandmo, this article explores contemporary discourses of military violence against civilians from a genealogical perspective. The purpose is to shed light on the historicity of certain structures of knowledge, thoughts, politics and ethics that are fundamental for the ways in which military violence against civilians is put into words, interprete
Early diagnosis and reliable prognosis and treatment prediction of breast cancer will ultimately lead to a decreased mortality rate. This can be achieved by identification of prognostic and treatment predictive biomarkers, and by understanding the mechanisms behind early changes in the breast. The cell cycle is a closely controlled process, involving multiple components with regulation on several
Background: Low blood levels of vitamin D (25-hydroxy D3, 25OHD3) in women have been associated with an increased risk of several diseases. A large part of the population may have suboptimal 25OHD3 levels but high-risk groups are not well known. The aim of the present study was to identify determinants for serum levels of 25OHD3 in women, i.e. factors such as lifestyle, menopausal status, diet and
Prostate cancer (PCa) is a heterogenous disease including very aggressive lethal tumors to incidentally discovered clinically insignificant tumors. Age, ethnicity, and family history are the only established risk factors. Type 2 diabetes mellitus (T2D) has been found to associate with increased overall cancer risk but with lower risk of specifically PCa. T2D is initially associated with increased
