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Background: A large number of different wound coverings have been used in order to improve the wound microenvironment, and thus accelerate repair. Since almost two centuries, clinicians and researchers have developed techniques for skin transplantation. In the past several decades, growth factors have been used as tools for accelerating and modifying skin wound repair. The experimental work in thi
PSII catalyses the light-induced water splitting process which leads to electron transfer through the thylakoid membrane and formation of energy rich molecules. Several redox components including a Mn4Ca, an amino acid residueYZ, two special Chl molecules P680, two Pheo and two quinone molecules participate in this process. Another component of PSII which interacts magnetically with Mn4Ca is D2-Ty
The gastrointestinal tract has two opposing functions; to effectively absorb nutrients and to act as a safety barrier against hazardous substances in the environment. After birth these functions develops gradually. The present thesis focuses on how the intestinal permeability and pancreatic secretion changes during ontogenic development of the pig, with some methodological aspects on manipulations
The influence of trauma (acute pancreatitis) or total parenteral nutrition (TPN) on pancreatic islet hormone secretion in relation to islet expression of inducible nitric oxide synthase (iNOS) was investigated. Acute pancreatitis resulted in an impaired glucose-stimulated insulin secretion (GSIS) which was found to be parallelled by a marked expression of iNOS and an exaggerated NO production in t
In this thesis asymmetrical flow field-flow fractionation (FFF) separations of ribosomes and subunits have been studied. Ribosomal material was prepared from Escherichia coli (E. coli) cells and analyzed by the size separation technique. The five main peaks in the fractograms correspond to transfer RNA (tRNA), unidentified proteins, small subunit, large subunit, and ribosome. The accuracy of the
Increasing awareness of the need of reducing CO2, NOx and SOx emissions from combustion systems has led to a strong interest in biomass as a fuel source. Using it in combination with fluidised bed combustion technology can lead to a lowering of NOx emissions to the atmosphere. However, this is not a problem-free technique, since the flue gas can contain ammonia, NOx and tar. The fluidised bed can
Atmospheric aerosol particles are believed to have an impact on the radiative forcing of the earth's surface. The predicted results indicate a net cooling effect on the global climate, however there are few studies available to substantiate this and experimental data are needed. This work deals with the collection and the analysis of aerosol particles in various environments, specifically in the
Some of the main factors affecting the biological removal of nutrients in wastewater treatment plants have been investigated. The influence of low concentrations of dissolved oxygen and the redox potential on the denitrification, activity of activated sludge was studied in batchwise experiments. Oxygen was found to have a negative effect on denitrification even when present at concentrations lower
The anaesthetics we use today dose-dependently decrease the mean arterial pressure partly due to direct or indirect effects on the blood vessels. In the present thesis human omental arteries and veins and rat femoral arteries were investigated in vitro concerning the effects of the intravenous anaesthetic propofol and the volatile anaesthetic sevoflurane on the function of the perivascular sympath
Proliferation, differentiation, and survival of hematopoietic stem cells and multipotent progenitor cells are regulated by cytokines and cell-cell interactions. Kit ligand (KL) and Flt3 ligand (FL) have pleiotropic effects, promotes survival, but are nonredundant. Using myeloid progenitor cell lines and mouse bone marrow-derived Lin- progenitors, we demonstrate that inhibition of phophatidylinosit
N-methyl-2-pyrrolidone (NMP) is an organic solvent widely used in the industry. Irritation of the eyes and in the respiratory system has been reported after occupational exposure to low air levels of NMP. The EU has also classified it as a developmental toxicant. NMP is easily absorbed in the gastrointestinal tract and airways and through skin. The general aim of this thesis was to develop
Cell-signalling via cytokines modulates the local response to surgical trauma, directs the immunologic response and initiates the healing process. Surgical trauma induces a systemic cytokine response and a down-regulation of the antigen presentation capacity of monocytes (HLA-DR expression), which is associated with a poor prognosis if pronounced. The aims with the studies in this thesis were to i
Smooth muscle cells (SMCs) in the vessel wall contract to regulate blood flow and pressure, a function essential for normal circulation through tissues. On the other hand, migration and proliferation of SMCs are important factors in vascular disease, such as atherosclerosis and restenosis following surgical dilatation. The conversion of the SMC to this role is marked by a modulation from contracti
Cholecystokinin (CCK) and the related hormone gastrin have been claimed to exert trophic effects in the pancreas and gastrointestinal tract. Two types of receptors for CCK and gastrin are known to exist, the CCK-A and the CCK-B receptor. They differ in their affinty for CCK and gastrin. The CCK-A receptor has about 500 times higher affinity for sulfated than for non-sulfated CCK and gastrin, while
The studies in this doctoral thesis investigated the concept of touch avoidance. Touch avoidance indicates a person’s negative affect toward physical contact/touch. In study 1 the aim was to develop a questionnaire that measures the level of touch avoidance. The results showed that touch avoidance can be measured along five different dimensions. The results are discussed in relation to attachment
The Influence of Pubertal Development on Autoantibody Appearance and Progression to Type 1 Diabetes in the TEDDY Study The Influence of Pubertal Development on Autoantibody Appearance and Progression to Type 1 Diabetes in the TEDDY Study Katharina Warncke,1,2 Roy Tamura,3 Desmond A. Schatz,4 Riitta Veijola,5 Andrea K. Steck,6 Beena Akolkar,7 William Hagopian,8 Jeffrey P. Krischer,3 Åke Lernmark,9
https://www.teddy.lu.se/sites/teddy.lu.se/files/2024-12/165%20Warncke_et%20al.%20Puberty%20JEndocrSoc_2024.pdf - 2026-04-30
Urban traffic involves frequent acceleration and deceleration. During deceleration, the energy previously used to accelerate the vehicle is mainly wasted on heat generated by the friction brakes. If this energy that is wasted in traditional internal combustion engines (ICE) could be saved, the fuel economy would improve. Today there are several solutions to meet the demand for better fuel economy
Wilms’ tumor gene 1 (WT1) is a zinc-finger transcription factor that is involved in the development of urogenital organs and mesothelial tissues. It was initially identified as a tumor suppressor gene, based on the observation that somatic inactivation of the gene predispose for development of the pediatric kidney cancer Wilms’ tumor. A role for WT1 in hematopoiesis was suggested based on the fact
This thesis dealswith the field of high-energy particle physics. It ismainly concernedwith two issues: the “renormalization of effective field theories” and the “detection of hidden sectors”. The first two papers are dedicated to the renormalization issue while the second two deal with the hidden sectors. Renormalization is crucial when one calculates physical observables to a high degree of preci
The studies upon which this thesis is based were designed to evaluate normal fetal and neonatal adaptation and the effects of obstetrical interventions during labor and delivery on fetal and neonatal cerebral circulation. Non-invasive Doppler ultrasound was used to record blood flow velocities from the middle cerebral artery (MCA) both antenatally from the fetus, and from the newborn in the early
