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Statins, commonly used to treat hypercholesterolemia, have also been proposed as anti-cancer agents. The identification of a predictive marker is essential. The 3-hydroxy-3-methylglutaryl-coenzyme-A reductase (HMGCR), which is inhibited by statins, might serve as such a marker. Thorough antibody validation was performed for four different HMGCR antibodies. Tumor expression of HMGCR (#AMAb90619, CL
Aims: Antimicrobial resistance presents an increasingly serious threat to global public health, which is directly related to how antibiotic medication is used in society. Actions aimed towards the optimised use of antibiotics should be implemented on equal terms and according to the needs of the population. Previous research results on differences in antibiotic use between socio-economic and demog
Krav på innehåll i blodkomponenter, virustest och kvalitetskriterier regleras i ett EU-direktiv och i Socialstyrelsens föreskrifter. Blodtransfusioner är en vanlig och viktig medicinsk behandling.Det saknas nationella riktlinjer för transfusionsindikationer och uppföljning av blodtransfusioner i Sverige.Det finns medicinsk evidens för en generellt restriktiv transfusionsstrategi.Vid stora blödning
The security behavior of small states has traditionally been explained by different takes of realism, liberalism, or constructivism – focusing on the behavior that aims toward safeguarding sovereignty or engaging in peace policies. The issue of why states with limited military capacities and little or no military alignments or engagements decide to participate in an international mission has recei
The focus of this paper is the relationship between regulatory settings and financial analysts’ performance, which is examined by studying the level of shareholder protection and the performance of financial analysts in two countries with different legal origins. By using a newly constructed index to measure shareholder protection, we are able to analyze how changes in shareholder protection over
Background: To expand our clinical and scientific knowledge about holistic outcomes within palliative care, there is a need for agreed-upon patient-reported outcome measures. These patient-reported outcome measures then require translation and cultural adaptation, either from country-specific languages to English, or the other way around. The aim of this study was to translate and cross-culturally
OBJECTIVE: Haemostatic imbalance may be an aetiological factor in the development of acute coronary syndromes. Inherited resistance to activated protein C (APC) is a common disorder associated with hypercoagulability and lifelong risk of venous thrombosis. APC resistance is due to a single mutation in the gene coding for coagulation factor V (FV:Q506). To test the importance of the FV:Q506 mutatio
Introduction. Online pharmacies are playing an increasingly important role for both citizens and society. In the digital landscape, both legal and illegal online pharmacies are competing for visibility and customer appeal. This article analyses the layout and characteristics of online pharmacy websites. Method. The article is based on a qualitative study of legal and illegal online pharmacy websit
Personality traits (e.g., the Big Five) shape human behavior, decision-making, and life outcomes. Evidence from various countries suggests that these traits are not randomly distributed but follow systematic regional patterns, fueling interest in their geographical variation. We analyze N = 22,225 geo-coded personality assessments, aggregated at regional levels. Using Hot Spot analysis (Getis-Ord
Författaren och litteraturforskaren Kjell Espmark (1930–2022) återkommer i åtskilliga texter – i både skönlitteratur och sakprosa – till en idé om att den svenska kulturen präglas av en omfattande historielöshet, eller en temporal provinsialism som han inte sällan benämner det. I den föreliggande artikeln studerar jag hur denna idé tar sig till uttryck i Espmarks satiriska kortroman Resan till Thu
Medicinsk rätt är ett brett rättsområde som behandlar juridiska aspekter på medicinsk verksamhet av olika slag. Historiskt har regleringen av medicinsk verksamhet fokuserat på nationella utmaningar. Krig och kriser har blivit viktiga väckarklockor för internationalisering av medicinsk rätt och skapandet av folkrättsliga regler på området. Behovet att skydda skadade personer under krig, liksom medi
