Publication in journal of clinical investigation
The Journal of Clinical Investigation R e s e a R c h a R t i c l e 1jci.org Introduction Upon inflammation, an array of brain-mediated responses occurs. They are collectively referred to as the sickness syndrome and include fever, decreased food intake, inactivity, social withdrawal, and corticosteroid secretion (1, 2). These objective symptoms are accompanied by feelings of malaise and discomfor