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This paper considers how researchers can best establish a forward trajectory in their work, individually and collectively. The suggestion is sometimes made in academic circles that it is inappropriate to present work that revisits an area previously discussed within the field. While we accept that any published paper should make an original contribution to what is collectively known about a partic

Chapter 1, Introduction

This book provides a number of studies of different aspects of Swedish child language. Some of the thematic chapters present original, unpublished data: on the acquisition of tense, on the range and frequency of different word order patterns in early child Swedish, related to the input, meaning the language of adults talking to the children or in the presence of the children. The remaining chapter

Broken technologies : the humanist as engineer. Updated November 2015

There are many possible definitions of “technology” and I will discuss some of these in this book. However, in this introduction let me use a definition of Svante Lindqvist who defines technology very intuitively as “those activities, directed towards the satisfaction of human wants, which produce change in the material world.” He says also “the distinction between human “wants” and more limited h

Altered Sensory Experience Exacerbates Stable Dendritic Spine and Synapse Loss in a Mouse Model of Huntington's Disease.

A key question in Huntington's disease (HD) is what underlies the early cognitive deficits that precede the motor symptoms and the characteristic neuronal death observed in HD. The mechanisms underlying cognitive symptoms in HD remain unknown. Postmortem HD brain and animal model studies demonstrate pathologies in dendritic spines and abnormal synaptic plasticity before motor symptoms and neurodeg

Antibody array generation and use.

Affinity proteomics, represented by antibody arrays, is a multiplex technology for high-throughput protein expression profiling of crude proteomes in a highly specific, sensitive, and miniaturized manner. The antibodies are individually deposited in an ordered pattern, an array, onto a solid support. Next, the sample is added, and any specifically bound proteins are detected and quantified using m

Monte Carlo simulation of defect-free cross-linked polyelectrolyte gels

Model systems of cross-linked polyelectrolyte gels were investigated by means of Monte Carlo simulations. The model contained a charged defect-free th ee-dimensional network of a diamond-like topology and explicit counterions. Pressure vs volume relations and chain extensions were determined and compared to those of the corresponding polyelectrolyte solution. The structure of the gel was character

Phase behavior of cetyltrimethylammonium surfactants with oligo carboxylate counterions mixed with water and decanol: Attraction between charged planes or spheres with oligomeric counterions

Cetyltrimethylammonium surfactants with a range of oligo carboxylate anions bearing. 2, 3, or 4 negative charges have been synthesized, and their respective behaviors in binary mixtures with water and in ternary mixtures with added decanol have been investigated. In binary mixtures with water, all surfactants formed nearly spherical micelles at high water contents; however, the interactions betwee

Effect of hydrophilically modified graft polystyrene on AOT oil-continuous microemulsions: Viscosifying effects of P(S-g-PEO) as a function of graft chain length and graft density

The effect of hydrophilically modified polystyrene, poly(styrene-g-poly(ethylene oxide)), P(S-g-PEC), on the viscosity of ACT oil-continuous microemulsions has been investigated as a function of PS and PEO chain lengths and PEO chain density. A series of polymers, P (S-g-PEO) with PEO chain lengths of 23 or 9, and different graft densities were synthesized by living radical polymerization. Thus, a

Lip kinematics in long and short stop and fricative consonants

This paper examines lip and jaw kinematics in the production of labial stop and fricative consonants where the duration of the oral closure/constriction is varied for linguistic purposes. The subjects were speakers of Japanese and Swedish, two languages that have a contrast between short and long consonants. Lip and jaw movements were recorded using a magnetometer system. Based on earlier work sho

Size, concentration, and solvency effects on the viscosifying behavior of PEO-PS-PEO triblock copolymers in AOT oil-continuous microemulsions

The effect of changing the block lengths of triblock copolymers of poly(ethylene oxide) -polystyrene -poly(ethylene oxide) on the relative viscosity of AOT oil-continuous microemulsions, with cyclohexane as the oil, was investigated. Five different microemulsion compositions were used to have (a) a series of increasing droplet concentration at constant droplet size and (b) a series with increasing

Liver dendritic cells present bacterial antigens and produce cytokines upon Salmonella encounter.

The capacity of murine liver dendritic cells (DC) to present bacterial Ags and produce cytokines after encounter with Salmonella was studied. Freshly isolated, nonparenchymal liver CD11c(+) cells had heterogeneous expression of MHC class II and CD11b and a low level of CD40 and CD86 expression. Characterization of liver DC subsets revealed that CD8alpha(-)CD4(-) double negative cells constituted t