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AIM: To assess the absolute and relative educational inequalities in mortality from hip and non-hip fractures in Skåne region, Sweden.METHODS: We conducted a population-based open cohort study. People aged 30-99 years, resident in the region during 1998-2013 ( n = 999, 148) were followed until death, their 100th birthday, relocation outside Skåne, or the end of 2014. We obtained individual-level d

Context: Pulmonary arterial hypertension (PAH) affects people of all ages and is associated with poor prognosis. Chronic breathlessness affects almost all people with PAH. Objectives: This randomized, placebo-controlled, double-blind, crossover study aimed to evaluate the effects of regular, low-dose, extended-release (ER) morphine for PAH-associated chronic breathlessness. Methods: Participants w

Objectives: The National Institutes of Health Stroke Scale (NIHSS) has not been validated to diagnose aphasia in the stroke population. We therefore examined the diagnostic accuracy of NIHSS for detecting aphasia in acute ischemic stroke. Methods: Consecutive patients with acute first-ever ischemic stroke were included prospectively in Lund Stroke Register Study at Skåne University Hospital, Swede

Objectives: Anti-neutrophil cytoplasmic autoantibodies [ANCA) are important for diagnosis of ANCA-associated vasculitides (AAV). The timing of antibody development is not well established. To investigate the development of proteinase 3 (PR3)- and myeloperoxidase (MPO)-ANCA, blood samples collected before onset of symptoms of AAV were analysed. Methods: To identify AAV patients with blood samples p

Increased blood lipid levels are heritable risk factors of cardiovascular disease with varied prevalence worldwide owing to different dietary patterns and medication use1. Despite advances in prevention and treatment, in particular through reducing low-density lipoprotein cholesterol levels2, heart disease remains the leading cause of death worldwide3. Genome-wideassociation studies (GWAS) of bloo

BACKGROUND AND AIMS: Adhering to the EAT-Lancet diet has been observed to be associated with lower risks of various morbidities. This study aimed to investigate the association of adhering to the EAT-Lancet diet with incident chronic obstructive pulmonary disease (COPD) and identify plasma proteins mediating such association.METHODS: This prospective study involved 202 340 participants free of COP

Bakgrund: Fotboll är en av världens största idrotter och i Sverige står fotbollen för ca en tredjedel av den samlade svenska idrottsrörelsen. Andelen damfotbollsspelare ökar ständigt. Man har sett att damfotbollsspelare löper en ökad risk för att drabbas av knäskador och då framförallt främre korsbandsskada. Denna skada är allvarlig då den innebär stora konsekvenser för både spelaren och samhället

H+ projektet i Helsingborg är ett stadsförnyelseprojekt som omfattar den centrala södra delen av staden. Projektet startades år 2002 och merparten förväntas vara bebyggt med bostäder, kontor och offentlig service år 2035. En miljon kvadratmeter mark som tidigare använts som hamn- och industriområde ska utvecklas, förnyas och länkas samman med centrum, söder och omkringliggande områden. Det första

The following report contains a study over what happens with the proposals for action that is presented in fire investigations. Literature, 105 fire investigations and interviews were used to gather information. The literature shows that proposals for action are a natural conclusion in almost all investigation methods but little over half of the fire investigations present them and only a few had

Trä och andra organiska material riskerar att angripas av mikrobiell påväxt under vissa temperatur- och fuktförhållanden. Mögel- och rötsvamp kan börja växa på trä om fukthalten är tillräckligt hög. Rötsvampar bryter ner träets olika beståndsdelar i olika utsträckning beroende på svamp- och trädart. Det som påverkar rötsvampars tillväxt är bland annat fukthalt, temperatur, pH-värde och syrehalt. E

Bakgrund: Inom läraryrket utgör stillasittandet en stor del av arbetsdagen, en riskfaktor som kan påverka den fysiska och psykiska hälsan negativt. Självskattningsfrågor är ett kostnadseffektivt sätt att skatta stillasittande. För att kunna dra tillförlitliga slutsatser gällande en persons stillasittande från självskattningsfrågor krävs det att dessa är valida. Syfte: Syftet med undersökningen var

Krillens barnkammare hotas av smältande havsis i Antarktis I den västra delen av den antarktiska halvön smälter havsisen. Den delen av södra oceanen är känd för sin stora rikedom och mängd av antarktisk krill, Euphausia superba. Krillen är beroende av havsisen för föda och beskydd. Den globala uppvärmningen försämrar krillens lekområden. Man ser nu en nedgång i krillbeståndets storlek och krillenAntarctic krill, Euphausia superba, a polar ocean specialist, thrives in the Antarctic severe physical conditions. The krill life cycle consists of strategies that have enabled and supported the species’ dominance of the Antarctic Ocean. Sea Ice extent and duration creates condition that are crucial for survival of the Furcilia larvae. The species has flexibility to food resources and is omnivorou

Background: Dietary pattern analysis has gained particular interest, because it reflects the complexity of dietary intake. The aim of this study was to explore the associations between a posteriori dietary patterns, derived using a data-driven approach, and the risk of differentiated thyroid cancer (TC) in Europe. Methods: This investigation included 450,064 adults from the European Prospective In

HIV infection affects the course of tuberculosis (TB), and HIV and Mycobacterium tuberculosis (Mtb) synergize in disease progression through complex immunological interplay. To gain further understanding of these mechanisms, we compared the microRNA (miRNA) and small nucleolar RNA (snoRNA) expression patterns in whole blood of individuals with active TB, with and without HIV coinfection (HIV+/TB+

Objectives: Type I interferons (IFNs) are central and reflective of disease activity in systemic lupus erythematosus (SLE). However, IFN-α levels are notoriously difficult to measure and the type I IFN gene signature (IGS) is not yet available in clinical routine. This study evaluates galectin-9 and an array of chemokines/cytokines in their potential as surrogate markers of type I IFN and/or SLE d

Heart failure (HF) and cancer are common diseases among the elderly population. Many chronic diseases, including diabetes mellitus (DM), share risk factors and increase the incidence of HF and cancer. The aim of this study was to investigate if there was an association between HF and the prevalence of haematologic- and solid malignancies. Methods The study population was comprised of almost one mi

Background and Aims: Microscopic colitis [MC] is currently regarded as an inflammatory bowel disease that manifests as two subtypes: collagenous colitis [CC] and lymphocytic colitis [LC]. Whether these represent a clinical continuum or distinct entities is, however, an open question. Genetic investigations may contribute important insight into their respective pathophysiologies. Methods: We conduc

Background: Aggregation of lung cancer (LCa) in family members is well-documented. However, little is known on the familial risk of LCa when first-degree relatives (FDRs, parents or siblings) are diagnosed with LCa as a second primary malignancy (LCa-2). We aimed to investigate whether and to what extent a family history of LCa-2 was associated with an increased LCa risk. Methods: In this Swedish

Summary: This study describes that low bone density is prevalent in premenopausal Saudi women, especially women of normal weight and vitamin D deficiency. Although BMD is higher in obese young women, this may not be beneficial later in life in conjunction with persistent vitamin D deficiency. Introduction: Not attaining peak bone mass is one crucial factor contributing to the risk of developing os