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Novel biomarkers for prediction of outcome in hip fracture patients—An exploratory study
Background: Little is known about the value of biomarkers for prognostication in hip fracture patients. The main objective of the present study was to assess if biomarkers add useful information to an existing risk score for prediction of 30-day mortality in patients suffering from out of hospital hip fractures. Methods: In a prospective observational single centre study, association between plasm
Främjar bibliotek verkligen demokrati?
Recension av Sam Popowich bok Confronting the Democratic Discourse of Librarianship
Surgical exploration without resection in pancreatic and periampullary tumors : report from a national database
Background and Aims: Pancreatic and periampullary cancers are sometimes found to have a too advanced disease during surgery to allow resection. The aim was to describe characteristics, treatment, outcome, and time trends for patients that were planned for pancreatic surgery but found unresectable during surgery. Material and Methods: Data from the Swedish National Pancreatic and Periampullary Canc
Välkomna! Introduktion till Symposiet Den akademiska friheten
Bosques vacíos, ¿una amenaza para combatir elcambio climático?
Reducing deforestation in Colombia while building peace and pursuing business as usual extractivism?
In this article, I examine the contradictions and tensions in Colombia's simultaneous embrace of REDD+ and a peace-building process premised on continued extractivism. Colombia is emerging from an internal conflict that lasted more than 50 years. In this process rural land-use is being transformed, generating new conflicts over land use and control with detrimental effects on Colombia's forests. B
Bränderna hota hela ekosystemet
Why Indigenous Hunting Is Essential to Forest Sustainability
Diokles från Karystos, Hälsosamt levnadssätt.
Översättning med inledning och förklarande noterDiocles of Carystus, Ὑφιενὴ δίαιτα. Translation into Swedish with introduction and explanatory notes
From lab-based studies to eye-tracking in virtual and real worlds : conceptual and methodological problems and solutions
Interferon-Gamma Receptor Signaling Plays an Important Role in Restraining Murine Ovarian Tumor Progression
Immune cell-derived cytotoxic pathways have been implicated in antitumor immune responses. The goal of this study is to characterize how these cytotoxic pathways influence ovarian cancer development. We have utilized the TgMISIIR-TAg transgenic mouse model which expresses the transforming SV40 TAg in the ovary, leading to spontaneous development of ovarian tumors that closely mimic human epithelia
Housing Temperature-Induced Stress Is Suppressing Murine Graft-versus-Host Disease through β2-Adrenergic Receptor Signaling
Graft-versus-host disease (GVHD) is the major complication of allogeneic hematopoietic cell transplantation, a potentially curative therapy for hematologic diseases. It has long been thought that murine bone marrow-derived T cells do not mediate severe GVHD because of their quantity and/or phenotype. During the course of experiments testing the impact of housing temperatures on GVHD, we discovered
Granzyme B-Mediated Activation-Induced Death of CD4+ T Cells Inhibits Murine Acute Graft-versus-Host Disease
Granzyme B (GzmB) has previously been shown to be critical for CD8(+) T cell-mediated graft-versus-host disease (GVHD) but dispensable for GVHD mediated by CD4(+) T cells. However, previous studies used high doses of CD4(+) T cells in MHC-mismatched models that caused rapid and lethal GVHD. Because of the hyperacute lethality, it is possible that the role of GzmB was concealed by the system. There
Defining immunological impact and therapeutic benefit of mild heating in a murine model of arthritis
Traditional treatments, including a variety of thermal therapies have been known since ancient times to provide relief from rheumatoid arthritis (RA) symptoms. However, a general absence of information on how heating affects molecular or immunological targets relevant to RA has limited heat treatment (HT) to the category of treatments known as "alternative therapies". In this study, we evaluated t
A flagellin-derived toll-like receptor 5 agonist stimulates cytotoxic lymphocyte-mediated tumor immunity
Toll-like receptor (TLR) mediated recognition of pathogen associated molecular patterns allows the immune system to rapidly respond to a pathogenic insult. The "danger context" elicited by TLR agonists allows an initially non-immunogenic antigen to become immunogenic. This ability to alter environment is highly relevant in tumor immunity, since it is inherently difficult for the immune system to r
Granzyme B-mediated damage of CD8+ T cells impairs graft-versus-tumor effect
Allogeneic hematopoietic cell transplantation is an established treatment for hematologic and other malignancies. Donor-derived immune cells can identify and attack host tumor cells, producing a graft-versus-tumor (GVT) effect that is crucial to the treatment. Using multiple tumor models and diverse donor-host combinations, we have studied the role of granzyme B (GzmB) in GVT effect. We first conf
A TLR5 agonist enhances CD8(+) T cell-mediated graft-versus-tumor effect without exacerbating graft-versus-host disease
Allogeneic hematopoietic cell transplantation is an established treatment for hematologic and nonhematologic malignancies. Donor-derived immune cells can identify and attack host tumor cells, producing a graft-versus-tumor (GVT) effect that is crucial to the effectiveness of the transplantation therapy. CBLB502 is a novel agonist for TLR5 derived from Salmonella flagellin. On the basis of TLR5-med
For love and for life: emotional dynamics at the World Congress of Families
The article explores the relationship between emotions, collective identity and mobilisation in conservative social movements through an analysis of the World Congress of Families’ (WCF) 13th international conference, held in Verona in March 2019. WCF promotes Christian family values and brings together anti-gay, anti-feminist and anti-abortion activists, religious leaders, and politicians from ar