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Aims: It has in recent years been established that epigenetic changes contribute to β-cell dysfunction and type 2 diabetes (T2D). For example, we have showed that the expression of histone deacetylase 7 (HDAC7) is increased in pancreatic islets of individuals with T2D and that increased levels of Hdac7 in β-cells impairs insulin secretion. The HDAC inhibitor MC1568 rescued this secretory impairmen

Aims and objectives: To explore municipal healthcare employees' experiences of relationships with care recipients and colleagues. The specific research questions were when do the relationships enhance well-being, and what prerequisites are needed for such relationships to occur? Background: Employees in health and social care for older people often depict their work in negative terms, and they oft

Regular prophylactic treatment with factor VIII (FVIII) and factor IX (FIX) concentrates in hemophilia A and B, respectively, is introduced in early infancy and has resulted in dramatic improvement of the conditions. Recombinant FVIII and FIX concentrates have been available for > 25 years and have been modified and refined through the years; however, unfortunately frequent intravenous administrat

Aims/hypothesis: It has been shown that children previously enrolled in follow-up studies have better glycaemic control during the early period after diabetes diagnosis. The aim of this study was to analyse glycaemic control over a longer period, past the period of partial remission, after diagnosis in children followed before diagnosis in the Swedish Diabetes Prediction in Skåne (DiPiS) study com

Changes to the smallest structures of the distal lung are often the first sign of severe respiratory disease, but to date methods to detect and quantify these changes are limited. Chronic obstructive pulmonary disease (COPD) is currently estimated to be the third most common cause of death worldwide, but is to a large extent under-diagnosed, especially at early stages. This thesis explores a new m

This presentation builds on several ethnographic fieldworks (2011-2015) in southern Sweden on people who have Palestinian background as well as my on-going informal involvement with Palestinian networks. The field material includes about 35 qualitative interviews, numerous informal discussions and participant observations of political events (mostly demonstrations and lectures) and people’s daily This presentation builds on several ethnographic fieldworks (2011-2015) in southern Sweden on people who have Palestinian background as well as my on-going informal involvement with Palestinian networks. The field material includes about 35 qualitative interviews, numerous informal discussions and participant observations of political events (mostly demonstrations and lectures) and people’s daily

For many applications, including future giant telescopes, there is increased interest in structural cables. Usually integrated models, i.e. combined models of structures, optics and control systems are used for modeling of telescopes. Performance of structural cables is non-linear, so often a linearization is needed to include cable models in integrated models of telescopes. We present two differe

We present an improvement to the snapshot imaging technique, FRAME, where the phase information is included in the illumination pattern estimation for image extraction. This can potentially improve the image storage capacity and resolution.

The main objective of this paper is to design a common background for various philosophical discussions about adequate conceptual analysis of “computation”.

Infection of vermiform nematodes by nematophagous fungi generally follows the same route whether the nematode is captured in adhesive traps of predatory fungi or mediated by conidia of endoparasites. A successful infection always results in complete digestion of the nematode corpus. The total time for the infection process varies between fungal species and also between species of nematodes being p

Dopamine (DA) neurons derived from human embryonic stem cells (hESCs) are a promising unlimited source of cells for cell replacement therapy in Parkinson's disease (PD). A number of studies have demonstrated functionality of DA neurons originating from hESCs when grafted to the striatum of rodent and non-human primate models of PD. However, several questions remain in regard to their axonal outgro

Further improvements in the clinical care of our most vulnerable patients-preterm infants-are needed. Novel diagnostic and surveillance tools facilitate such advances. The GASMAS technique has shown potential to become a tool to, noninvasively, monitor gas in the lungs of preterm infants, by placing a laser source and a detector on the chest wall skin. It is believed that this technology will beco