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Background Palatable food access promotes obesity leading some to diet. Here, we modeled the roles of duration, intermittency and choice of access in bingeing, escalation of daily intake, and underacceptance of alternatives. Method Female rats with (“Choice”) or without continuous chow access, received chow or continuous (Chocolate), intermittent (MWF) long (24 h, Int-Long), or intermittent short

Background: Mucociliary clearance (MCC) rate from the lung has been shown to be reduced in chronic obstructive pulmonary disease (COPD). This study compared the use of change in penetration index (PI) with conventional whole lung clearance in assessing MCC in mild-to-moderate disease. Methods: Measurement of lung MCC using planar gamma camera imaging was performed in three groups: (1) healthy nons

The neutron-deficient mercury isotopes serve as a classical example of shape coexistence, whereby at low energy near-degenerate nuclear states characterized by different shapes appear. The electromagnetic structure of even-mass 182-188 Hg isotopes was studied using safe-energy Coulomb excitation of neutron-deficient mercury beams delivered by the REX-ISOLDE facility at CERN. The population of 01,2

An increased use of wood can reduce the environmental footprint of the building sector by being a renewable and ecological material. In order to improve the competitiveness of heavy timber structures, this thesis presents a novel type of timber connection with a high degree of prefabrication, which utilizes a resilient bond line.It has previously been shown that a large conventional stiff adhesive

This chapter describes some of the special neurochemical features of the areas of the brain selectively vulnerable to ischemic and hypoglycemic insults. The chapter focuses on the neuronal connections to the vulnerable brain areas, on the distribution of receptors and transmitter content in the vulnerable areas, and on some current hypothesis of neuronal damage. Emphasis will be placed on a possib

An increased use of wood can reduce the environmental footprint of the building sector. In order to improve the competitiveness of heavy timber structures, the thesis presents a novel type of timber connection with a high degree of prefabrication. The connection includes a resilient bond line, meaning an elastic bond line with low stiffness yet high fracture energy.It has previously been shown tha

Background: Earlier age at menopause has been associated with increased risk of coronary heart disease (CHD), but the shape of association and role of established cardiovascular risk factors remain unclear. Therefore, we examined the associations between menopausal characteristics and CHD risk; the shape of the association between age at menopause and CHD risk; and the extent to which these associ

Probiotics are linked to positive regulatory effects on the immune system. The aim of the study was to examine the association between the exposure of probiotics via dietary supplements or via infant formula by the age of 1 year and the development of celiac disease autoimmunity (CDA) and celiac disease among a cohort of 6520 genetically susceptible children. Use of probiotics during the first yea

The gas phase electronic structure of two transition metal alkylamino complexes, M(N(CH3)2)4, where M = Ti, Hf, was studied using photoelectron spectroscopy and density functional theory (DFT). These studies are a first step for predicting atomic layer and chemical vapor deposition reactions on surfaces, which are common applications of these molecules. The valence photoemission spectra of these t

Huntingtons sjukdom (HS) är en ärftlig fortskridande neurodegenerativ sjukdomsom orsakas av en förlängd CAG sekvens i huntingtin (HTT) genen, vilket leder till motoriska och kognitiva symptom samt personlighetsförändringar. Eftersom den muterade genen och proteinet den kodar för finns uttryckt i kroppens alla celler resulterar det i att även organ utanför hjärnan påverkas. En förhöjd ämnesomsättniHuntington´s disease (HD) is a fatal inherited neurodegenerative disorder caused by a CAG triplet repeat expansion in the huntingtin (HTT) gene and characterized by cognitive and motoric dysfunctions as well as psychiatric problems. Accumulating evidence, however, suggests altered energy metabolism and a hyper-catabolic state as key features of HD pathology. In clinical HD, body weight has been sh