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Molecular titration is emerging as an important biochemical interaction mechanism within synthetic devices built with nucleic acids and the CRISPR/Cas system. We show that molecular titration in the context of feedback circuits is a suitable mechanism to enhance the emergence of oscillations and bistable behaviors. We consider biomolecular modules that can be inhibited or activated by input monome

The paper presents and analyses some nonlinear continuous-time dynamic models of social systems whose members, groups or individuals, may change partners and/or opponents at any time, according to a greedy criterion. The main structural properties of these models, which belong to the class of positive switching systems, are investigated with particular regard to the existence of solutions, their p

Structural properties, independent of specific parameter values, can explain the robustness of biochemical systems. In this paper we consider the framework previously proposed by the authors to assess structural stability of biochemical reaction networks with monotone reaction rates, which considers systems in concentration coordinates, and we show that the results can be applied to systems in rea

Primary torsion dystonia (PTD) occurs due to a genetic mutation and often advances gradually. Currently, there is no therapy available that is able to inhibit progression. Neural stem cells (NSCs) are being investigated as potential therapies for neurodegenerative diseases, such as stroke and trauma. The present study evaluated the clinical effectiveness of NSC transplantation in an 18-year-old ma

We consider the problem of identifying structural influences of external inputs on steady-state outputs in a biological network model. We speak of a structural influence if, upon a perturbation due to a constant input, the ensuing variation of the steady-state output value has the same sign as the input (positive influence), the opposite sign (negative influence), or is zero (perfect adaptation),

We consider the flow control problem for a general class of compartmental nonlinear systems, which can be associated with a graph whose nodes represent subsystems with their own internal dynamics, and whose arcs represent flow links among them. We consider a network-decentralized control: each agent controls a link between two nodes and decides its actions based on the states of these nodes only.

A major drawback hinders the application of Model Predictive Control (MPC) to the regulation of electromechanical systems or, more generally, systems with fast dynamics: the time needed for the online computation of the control is often too long with respect to the sampling time. This paper shows how this problem can be overcome by suitably implementing the MPC technique. The main idea is to compu

We consider the problem of stabilizing a class of systems formed by a set of decoupled subsystems (nodes) interconnected through a set of controllers (arcs). Controllers are network-decentralized, i.e., they use information exclusively from the nodes they interconnect. This condition requires a block-structured feedback matrix, having the same structure as the transpose of the overall input matrix

A novel approach to the problem of inverse kinematics for redundant manipulators has been recently introduced: by considering the joints as point masses in a fictitious gravity field, and by adding proper constraints to take into account the length of the links, the kinematic inversion may be cast as a convex programming problem. Such a problem can be solved in an efficient way and may be easily m

This paper deals with set invariance for time delay systems. The first goal of the paper is to review the known necessary or sufficient conditions for the existence of invariant sets with respect to dynamical systems described by discrete-time delay difference equations (dDDEs). Secondly, we address the construction of invariant sets in the original state space (also called D-invariant sets) by ex

The paper analyses some continuous-time dynamic models that describe the evolution of social systems characterized by the possibility of changing the alliances among the parties involved or damaging one's competitors. At any time each participant, either an individual or a coalition, can decide to form or terminate a bond, or to start or stop damaging an opponent (i.e., to switch from a network co

In this chapter, a control design approach based on linear parametervarying (LPV) systems, which can be exploited to solve several problems typically encountered in control engineering, is presented. By means of recent techniques based on Youla–Kucera parametrization, it is shown how it is possible not only to design and optimize stabilizing controllers, but also to exploit the structure of the Yo

Most of the existing techniques for palmprint recognition are based on metrics that evaluate the distance between a pair of features. These metrics are typically based on static functions. In this paper we propose a new technique for palmprint recognition based on a dynamical system approach, focusing on preliminary experimental results. The essential idea is that the procedure iteratively elimina

Due to the intrinsic uncertainty and variability affecting biochemical reaction networks, it is fundamental to assess their structural stability, i.e., to establish if all the networks having a given structure are stable independent of specific parameter values. For basic motifs in biochemical networks, we show that stability cannot be structurally proved by quadratic Lyapunov functions. However,

We design a new negative feedback molecular oscillator and study its properties analytically and numerically. This oscillator is composed of two synthetic genes interconnected through their RNA outputs. Regulation of the genes activity is achieved by controlling the activity of the enzymes rather than the activity of the promoters. We show that a simple model of this system has the potential to os

We propose a negative feedback architecture that regulates activity of artificial genes, or "genelets", to meet their output downstream demand, achieving robustness with respect to uncertain open-loop output production rates. In particular, we consider the case where the outputs of two genelets interact to form a single assembled product. We show with analysis and experiments that negative autoreg

Molecular systems are uncertain: The variability of reaction parameters and the presence of unknown interactions can weaken the predictive capacity of solid mathematical models. However, strong conclusions on the admissible dynamic behaviors of a model can often be achieved without detailed knowledge of its specific parameters. In systems with a sign-definite Jacobian, for instance, cycle-based cr

We consider a traffic control problem defined on a network graph, whose nodes represent buffers and whose arcs represent flow channels. We consider network models with a peculiar aspect: each element of the flow arriving at each node must be redirected towards a precise other node of the network, hence each buffer is naturally split in several queues, characterized according to statistics about th

We consider the problem of assessing structural stability of biochemical reaction networks with monotone reaction rates, namely of establishing if all the networks with a certain structure are stable regardless of specific parameter values. We investigate stability by absorbing the network equations in a linear differential inclusion and seeking for a polyhedral Lyapunov function proper to the con

This paper focuses on the regulation of RNA production for in vitro synthetic gene networks. We consider the problem of matching the production rate of several RNA species concurrently transcribed to form RNA complexes. We design regulatory feedback loops based on two schemes: negative auto-regulation (which can minimize the potentially harmful amount of molecules not used to form products) and cr