BACKGROUND: We aimed to identify the target of deprescribing, i.e. the 24-hour SBP increase needed to achieve the greatest reduction of SBP drops.METHOD: Forty hypertensive patients (mean age 73.6 ± 9.3 years, 26 females) with reflex syncope and SBP drops on a screening ABPM were advised to withdraw or to reduce their therapy. The study objective was the reduction of SBP drops

Constitutional polymorphisms in ARID5B are associated with an increased risk of developing high hyperdiploid (HeH; 51–67 chromosomes) pediatric B-cell precursor acute lymphoblastic leukemia (BCP ALL). Here, we investigated constitutional and somatic ARID5B variants in 1335 BCP ALL cases from five different cohorts, with a particular focus on HeH cases. In 353 HeH ALL that were heterozygous for ris

Two new genera, Petiolachertus and Macroplectron, each with two new species, P. castor and P. pollux, T. nishidai and T. safron, respectively, are described. Petiolachertus belongs in the tribe Eulophini and Macroplectron in Cirrospilini. Petiolachertus castor, P. pollux and T. nishidai are described from both sexes and have been reared from Gracillariidae leaf miners (unidentified Gracillariidae

Concussion, caused by a rotational acceleration/deceleration injury mild enough to avoid structural brain damage, is insufficiently captured in recent preclinical models, hampering the relation of pathophysiological findings on the cellular level to functional and behavioral deficits. We here describe a novel model of unrestrained, single vs. repetitive concussive brain injury (CBI) in male C56Bl/

International law is becoming increasingly more specialized and diversified. In response to these developments, international lawyers now widely refer to international investment law, European human rights law and many other branches as ‘special regimes’. Scholars in the field see the proliferation of special regimes as a threat to the unity of the international legal system. In so doing, they are

The paper presents new geological, geochronological, geochemical and Nd-Sr isotopic data on the Meso- Neoproterozoic dolerites of the Siberian Craton. New U-Pb baddeleyite and apatite ages of a E-W-trending dyke and two sills from southeastern Siberia are 982 ± 11, 977 ± 7, 970 ± 31 and 972 ± 60 Ma, respectively, extending the area of distribution of the event by more than 100 km to the north. The

The mammalian skin is a densely innervated soft tissue where neural mechanoreceptors embedded in the skin report to the brain the mechanical events arising at its surface. Up to now, models of the transformations of these events into neural signals relied on quasi-static or viscoelastic mechanical models of the skin tissue. Here we developed a model, which, in addition to elasticity and viscosity,

Progenitor cells adapt their behavior in response to tissue demands. However, the molecular mechanisms controlling esophageal progenitor decisions remain largely unknown. Here, we demonstrate the presence of a Troy (Tnfrsf19)-expressing progenitor subpopulation localized to defined regions along the mouse esophageal axis. Lineage tracing and mathematical modeling demonstrate that Troy-positive pro

Four isostructural oxovanadium(V) complexes with hydrazone ligands have been synthesised, characterised, and evaluated as epoxidation and sulfoxidation catalysts. The reactions between [VO(acac)2] (acac– = acetylacetonate) and H2Ln (n = 1–4), precursors for monoanionic tridentate hydrazone ligands, afford complexes formulated as [VO(Ln)(bzh)·MeOH] (1–4) when bidentate benzohydroxamic acid (Hbzh) i

This paper constructs annual GDP estimates for Ireland (1924-47) to join the first complete official aggregates. The new series is deployed to revisit Ireland’s economic performance in the post-independence decades. Ireland’s economy grew at 1.5 per cent per annum and average living standards improved by 40 per cent. The bulk of this was due to labour productivity improvements stemming from worker

Subject movements and other disturbances might contaminate the Magnetic Resonance Spectroscopy data, and these artifacts can be misinterpreted as actual metabolite signals by the quantification program. Thus, an automatic method could be very helpful for finding artifacts and eliminating them. In this work, an approach of using correlation analyses was tested in order to evaluate if motion contami

Recension av Lennart Pehrson, "Vithetens lön: En historia om rasism"

This volume engages with the alarming convergence of far right thinking and the ecological crisis in contemporary society. Growing out of the first international conference on political ecologies of the far right, the volume gathers crucial insights from authorities in the field as well as promising early career researchers. With cases ranging from ethnographical accounts of fossil fuel populist p

Detecting failures early in cloud-based software systems is highly significant as it can reduce operational costs, enhance service reliability, and improve user experience. Many existing approaches include anomaly detection in metrics or a blend of metric and log features. However, such approaches tend to be very complex and hardly explainable, and consequently non-trivial for implementation and e

With the dynamic nature of modern software development and operations environments and the increasing complexity of cloud-based software systems, traditional monitoring practices are often insufficient to timely identify and handle unexpected operational failures. To address these challenges, this paper presents the findings from a quantitative industry survey focused on the application of Machine