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Early metastatic spread and clonal expansion of individual mutations result in a heterogeneous tumour landscape in metastatic urothelial cancer (mUC). Substantial molecular heterogeneity of common drug targets, such as membranous NECTIN4, FGFR3 mutations, PDL1 or immune phenotypes, has been documented between primary and metastatic tumours. However, translational and clinical studies frequently do
Against the backdrop of tension between China and the United States, both South Korea and Europe are keen to find ways to diversify their R&D partners.
The early evolution of sex chromosomes has remained obscure for more than a century. The Vandiemenella viatica species group of morabine grasshoppers is highly suited for studying the early stages of sex chromosome divergence and degeneration of the Y chromosome. This stems from the fact that neo-XY sex chromosomes have independently evolved multiple times by X-autosome fusions with different auto
Alzheimer’s disease can be treated by targeting amyloid-β plaques and diagnosed in vivo by biomarkers, prompting the revision of criteria for the diagnosis and staging of this disease.
Using a case-controlled study including siblings of major depression (MD) and control probands, born 1970–1990 and followed through 2018, we sought to clarify the degree to which the familial liability to MD is reflected in its clinical features, and the pattern of psychiatric disorders at elevated risk in the siblings of MD probands. The study population included full-siblings of 197,309 MD and m
Opportunistic mobile predators can adapt their behaviour to specific foraging scenarios, allowing them to target diverse prey resources. An interesting example is the harbour porpoise (Phocoena phocoena), a marine mammal with a huge energy demand feeding on a large variety of fish, squid and shrimps. Little is known about the foraging behaviour of harbour porpoises, as observations of wild specime
The advent of tyrosine kinase inhibitors (TKIs) as treatment of chronic myeloid leukemia (CML) is a paradigm in molecularly targeted cancer therapy. Nonetheless, TKI-insensitive leukemia stem cells (LSCs) persist in most patients even after years of treatment and are imperative for disease progression as well as recurrence during treatment-free remission (TFR). Here, we have generated high-resolut
Children with left heart disease are at risk for developing pulmonary hypertension, initially secondary to pulmonary venous hypertension that can progress to include elevated pulmonary vascular resistance, known as combined pre- and postcapillary pulmonary hypertension. Elevated pulmonary vascular resistance may pose a risk to the right ventricle of a newly transplanted heart because of increased
Purpose: This study explores variation theory-based interventions’ contribution to enhancing preschoolers’ subitizing abilities during iterative lessons. Results are presented according to low, middle and high achievers, focused on those with prominent challenges. Design/methodology/approach: In total 68 Swedish preschoolers participated. They were randomly assigned to one of the intervention/cont
Objective: To assess the association between achievement of prostate-specific antigen (PSA) levels ≤0.2 ng/mL (henceforth ‘ultralow’) and clinical outcomes in patients in the ‘Targeted Investigational Treatment Analysis of Novel Anti-androgen’ (TITAN) study (ClinicalTrials.gov Identifier NCT02489318) with metastatic castration-sensitive prostate cancer (mCSPC). Patients and Methods: Patients in th
Ticks are known vectors of various pathogens, including bacteria, parasites and viruses, that impact both animal and human health. Improving knowledge of the distribution of tick-borne pathogens, combined with their early detection in ticks, are essential steps to fight against tick-borne diseases and mitigate their impacts. Here we give an overview of what are the common methods of pathogen detec
The Last Hour is one of plan b's series of works with spontaneous, real time text. Like How Do You Keep Talking, what we say is not rehearsed or set but happens in the moment. We set ourselves the task of saying everything we have left out of our relationship until now, as if we had one last hour together. We sit behind a long table with two microphones, dressed formally as if attending a press co
We claim that double moments of twoparticle distributions are very sensitive quantities for testing the opposite side quantum number correlations ine + e −-annihilation predicted by the quark parton model. In particular it is found that kaon correlations are extremely transparent in these quantities. This feature survives when the QCD predictedQ 2-dependence is taken into account. We also stress t
The Day the Books Took Off was a sited piece for the International English Library in Düsseldorf for the 'Stadtprojekt: Wenn die Häuser Trauer Tragen' - (When the Buildings Carry Grief) as part of Impulse Festival in 2018. The extension to the Wilhelm-Marx-Haus (one of the first skyscrapers in Europe when it was built in 1924) currently houses a number of public institutions, among them the Forum
A performance lecture based on the extensive daily recordings with a GPS that Daniel Belasco Rogers and Sophia New have been collecting, a practice they continue to the present. Within the framework of the urban choreographic lab Stadterweitern in Berlin they presented some thoughts and reflections on data, memory, daily practice, intimacy, physicality, distance and sharing space and time for deca
