The enzyme myeloperoxidase shows several unusual properties compared to other peroxidases, e.g. a red-shifted absorption spectrum and a peroxidase activity towards chloride. It has been suggested that this is caused by the unusual covalent links between the heme group and the surrounding protein, but whether it is caused by the two ester links to Glu-242 and Asp-94 or the sulfonium ion linkage to

The aim of this was to determine whether the change of size observed at the first response evaluation after initiation of first-line combination chemotherapy correlates with overall survival (OS) in patients with metastatic breast cancer (MBC). The change in size of tumors derived from measurements according to Response Evaluation Criteria In Solid Tumors (RECIST) at the first evaluation on comput

This paper analyses global climate politics from the 2007 Bali Roadmap over the 2009 breakdown at COP15 to the following COP meetings with a focus on central issues and tendencies. The analysis is structured by applying the concepts of content and process as empirical and heuristic tools. This is used as the point of departure to analyse the road to Paris, where COP21 is held in 2015 with the stat

This paper examines the importance of influent fractionation, kinetic, stoichiometric and mass transfer parameter uncertainties when modeling biogas production in wastewater treatment plants. The anaerobic digestion model no. 1 implemented in the plant-wide context provided by the benchmark simulation model no. 2 is used to quantify the generation of CH4, H-2 and CO2. A comprehensive global sensit

Adaptive radiations have long served as living libraries to study the build-up of species richness; however, they do not provide good models for radiations that exhibit negligible adaptive disparity. Here, we review work on damselflies to argue that nonadaptive mechanisms were predominant in the radiation of this group and have driven species divergence through sexual selection arising from male-f

Denna rapport är en redovisning av arbete utfört inom projektet "Kyrkomusikaliskt nätverk" vilket varit ett delprojekt inom det övergripande projektet "Nordkalottens universitet".

Data on net CO2 exchange from eight forests in Denmark, Sweden, Finland and Iceland were used to analyse which factors were controlling photosynthesis and respiration. The forests consisted of different species ranging in climatic condition from temperate to subarctic. Only well mixed conditions were analysed (u* > 0.3 m s(-1)). The parameters of a light response function showed strong seasonal va

Conclusion: The study showed the value of using intravital microscopy (IVM) analysis for the study of neoangiogenesis. It demonstrated that the model and the analytical methodology could be used to evaluate in detail the effects of treatment strategies for solid tumours. Objectives: Neoangiogenesis is a key component of tumour progression, invasion and metastasis. In clinical trials monoclonal ant

Bone scintigraphy is usually obtained as a whole-body scan producing 2 images: an anterior view and a posterior view. Sometimes abnormal findings in the spine are difficult to distinguish on whole-body bone scans. SPECT/CT may be performed to localize and interpret a lesion correctly and to help differentiate between benign and metastatic lesions. The assessment of whether SPECT/CT is needed is us

Global food production is identified as a great threat to the environment. In combination with technical advances in agriculture, dietary change is suggested to be necessary to reduce the environmental impact of the food system. In this article a systematic review assessing the environmental impact of dietary change is performed. The aims are to i) evaluate the scientific basis of dietary scenario

Background: During the last decades, global migration has increased and many immigrant groups have a higher prevalence than the native born population of several cardiovascular disease risk factors, including poor dietary habits. However, it is uncertain if dietary habits in immigrant populations reflect dietary habits in their country of origin or if the current diet is a consequence of the migra

The time-dependent fluorescence frequency shift of protein-attached probes has a much slower decay than that for the free probe. The decay times, ranging from 10 ps to several nanoseconds, have been attributed to hydration water motions several orders of magnitude slower than those in the hydration shell of small solutes. This interpretation deviates strongly from the prevailing picture of protein

Local adaptation is an important process contributing to population differentiation which can occur in continuous or isolated populations connected by various amounts of gene flow. The willow warbler (Phylloscopus trochilus) is one of the most common songbirds in Fennoscandia. It has a continuous breeding distribution where it is found in all forested habitats from sea level to the tree line and t

Through the combination of surface sensitive photoelectron spectroscopy and molecular dynamics simulation, the relative surface propensities of guanidinium and ammonium ions in aqueous solution are characterized. The fact that the N Is binding energies differ between these two species was exploited to monitor their relative surface concentration through their respective photoemission intensities.

The core sense of accountability is the demanding and giving of accounts. Especially, when the outcome is negative, the management can be expected to account for the failure event, contextualizing the numerical outcome. In this paper the particular failure event of goodwill impairment, and the response of the management in the financial report is studied. Even though not necessarily being a failur

Background: Avian malaria (Plasmodium sp.) is globally widespread, but considerable variation exists in infection (presence/absence) patterns at small spatial scales. This variation can be driven by variation in ecology, demography, and phenotypic characters, in particular those that influence the host's resistance. Generation of reactive oxygen species (ROS) is one of the host's initial immune re

A measurement is presented of inelastic photoand electroproduction of J/psi mesons in ep scattering at HERA. The data were recorded with the H1 detector in the period from 2004 to 2007. Single and double differential cross sections are determined and the helicity distributions of the J/psi mesons are analysed. The results are compared to theoretical predictions in the colour singlet model and in t