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Isoform distribution and tissue contents of contractile and cytoskeletal proteins in hypertrophied smooth muscle from rat portal vein

Growth of the smooth muscle in the rat portal vein was initiated by an increased transmural pressure. After 7 days, the cross-sectional area of the vessel wall and the maximal active force of the longitudinal muscle layer had increased twofold. Electron microscopy showed that the cell cross-sectional area was increased, suggesting cellular hypertrophy. Increased amounts of intermediate (10 nm) fil

Delayed Onset of Ototoxic Effects of Gentamicin in Patients with Meniére's Disease

In treatment of Meniére's disease, installations of gentamicin are continued until there are signs of disturbance of vestibular or cochlear function. However, since it has been demonstrated that gentamicin is eliminated slowly from the inner ear, a continuing ototoxic effect may be suspected. The present study aimed to investigate the delay of onset of symptoms of ototoxic effects. Five patients w

Latent Autoimmune Diabetes in Adults: Definition, Prevalence, {beta}-Cell Function, and Treatment.

Latent autoimmune diabetes in adults (LADA) is a disorder in which, despite the presence of islet antibodies at diagnosis of diabetes, the progression of autoimmune ß-cell failure is slow. LADA patients are therefore not insulin requiring, at least during the first 6 months after diagnosis of diabetes. Among patients with phenotypic type 2 diabetes, LADA occurs in 10% of individuals older than 35

Changes of bone mineral mass and soft tissue composition after hip fracture

The aim of this prospective longitudinal study was to measure prospectively the bone mineral density (BMD) and anthropometric variables after a hip fracture. In particular, we studied changes in the BMD in both the injured and uninjured hips, and examined if the postoperative mortality rate and complications, including pseudarthrosis of the fracture and late segmental collapse of the head of the f

Association between SLE nephritis and polymorphic variants of the CRP and Fc gamma RIIIa genes

Objectives. To study the relationship between clinical manifestations in systemic lupus erythematosus (SLE) with polymorphisms in suggested susceptibility genes encoding Fc gamma RIIa, Fc gamma RIIIa, Fc gamma RIIIb, CRP and IL-1Ra. Methods. Genetic polymorphisms were analysed in 323 unrelated SLE patients and 200 healthy blood donors. The genotype frequencies were compared between clinical subset

Managing cardiovascular risk: reality vs. perception

Clinical practice guidelines attempt to bridge the gap between the generation of scientific evidence and its application. For cardiovascular risk reduction, the implementation of knowledge into practice, both with respect to lifestyle change and pharmacological treatment, has been shown to be poor. There are several reasons for this 'guidelines gap', with physician factors including insufficient t

CO2 induced acute respiratory acidosis and brain tissue intracellular pH: a P-31 NMR study in swine

High concentration carbon dioxide (CO2) is used to promote pre-slaughter anaesthesia in swine and poultry, as well as short-lasting surgical anaesthesia and euthanasia in laboratory animals. Questions related to animal welfare have been raised, as CO2 anaesthesia does not set in momentarily. Carbon dioxide promotes anaesthesia by lowering the intracellular pH in the brain cells, but the dynamics o

Titchmarsh-Weyl M-function asymptotics and some results in the inverse spectral theory for vector-valued Sturm-Liouville equations and a certain higher order ordinary differential equation

Popular Abstract in Swedish Denna avhandling utgöres av två separata rapporter, där studieobjektet för den första är en vektorvärd Sturm-Liouville ekvation på formen -(PU')'+QU=zU, xin[0,b), med P^{-1},W,Q hermiteska med lokalt integrerbara matriselement; och under vissa ytterligare villkor på P^{-1} och W. Under dessa förutsättningar härleds några huvudresultat beträf- fande asymptotiken, då z igThis discourse is constituted by two separate reprots, where the first one offers an elementary deduction of the leading order term asymptotics for the Titchmarsh-Weyl M-function corresponding to a vector-valued Sturm-Liouville equation of the form -(PU')'+QU=zu, xin[0,b), with P^{-1},W,Q being hermitean with locally integrable entries; and under some additional conditions on P^{-1} and W. In the

Core polarization in Ca I and Ca II

The effect of core polarization on binding energies, term splitting, fine structure, and transition probabilities is investigated for the low lying states 4s2S, 3d2D, 4p2P(o) in Ca II and 4s2(1)S, 4s4p1,3P(o) in Ca I. Results from inclusions of core polarization in the form of model potentials are compared with explicit MCHF calculations, and the accuracy of the different approaches is discussed.

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Abstract in French La géométrie du tissue urbain a une grande influence sur le microclimat et influence donc le confort thermique extérieur des habitants et, le microclimat urbain influence à son tour indirectement le climat intérieur. Une mauvaise adaption climatique des environnements urbains a souvent pour conséquence l'utilisation d'une climatisation active et ainsi une augmentation de la cons

Jawed polychaetes from the Upper Sylvan Shale (Upper Ordovician), Oklahoma, USA

A jawed polychaete fauna from the upper 30 in of the Upper Ordovician Sylvan Shale (Richmondian, Ash-ill) of Oklahoma is described, based on recovered scolecodonts (polychaete jaws). The fauna includes members of six families: Paulinitidae, Ramphoprionidae, Polychaetaspidae, Atraktoprionidae, Hadoprionidae, and Kalloprionidae. Ten species are identified and one new paulinitid species, Ketmerites (

System weaknesses as contributing causes of accidents in health care

Objectives. Accidents in health care, resulting in injury or death to the patient, are a matter of considerable concern. The aim of this study is to examine whether system weaknesses can contribute to these accidents, and if so, how. Design. Eight consecutive accidents reported to the Health Authority in Sweden were analysed using MTO (Man-Technique-Organization) analysis. Setting. Emergency care

One-year follow-up of cognitive behavioral therapy for phobic postural vertigo

Background Phobic postural vertigo is characterized by dizziness in standing and walking despite normal clinical balance tests. Patients sometimes exhibit anxiety reactions and avoidance behavior to specific stimuli. Different treatments are possible for PPV, including vestibular rehabilitation exercises, pharmacological treatment, and cognitive behavioral therapy. We recently reported significant