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Anti-cancer potency of tasquinimod is enhanced via albumin-binding facilitating increased uptake in the tumor microenvironment.
Tasquinimod, an orally active quinoline-3-carboxamide, binds with high affinity to HDAC4 and S100A9 in cancer and infiltrating host cells within compromised tumor microenvironment inhibiting adaptive survival pathways needed for an angiogenic response. Clinical trials document that as low as 0.5-1mg tasquinimod/day is therapeutic against castrate resistant metastatic prostate cancer. Tasquinimod i
Changing the Paradigm: A Requisite for Safe and Sustainable Coastal Societies
The importance of understanding norm-creation processes in the work towards efficient regulations
Turnover of Human Cardiomyocytes
Inclusion of the quadrupole moment when describing polarization. The effect of the dipole-quadrupole polarizability.
A method to compute distributed dipole-quadrupole polarizabilities is suggested. The method is based on numerical differentiation of distributed quadrupole moments, using finite field perturbation calculations. It is tested using two different multicenter multipole expansions, and compared with results using polarizabilities obtained via the uncoupled Hartree-Fock approximation. The accuracy of th
Infliximab as rescue therapy in hospitalised patients with steroid-refractory acute ulcerative colitis: a long-term follow-up of 211 Swedish patients
BackgroundRescue therapy with infliximab (IFX) has been proven effective in a steroid-refractory attack of ulcerative colitis (UC). The long-term efficacy is not well described. AimTo present a retrospective study of IFX as rescue therapy in UC. Primary end points were colectomy-free survival at 3 and 12months. MethodsIn this multicentre study, 211 adult patients hospitalised between 1999 and 2010
In memoriam: Leif Carserud
Surveillance and File-Sharing: Two Issues Engaging the Unengaged
Abstract in UndeterminedOver the last decade a great deal of research attention has been paid to the Internet as a potential vehicle for civic and/or political engagement among young people. Many of these analyses have been looking (or perhaps hoping) for a simple cause-and-effect relationship. Young people seem uninterested in traditional forms of politics, but they are very interested in Interne
The duration of trade revisited. Continuous-time versus discrete-time hazards
The recent literature on the duration of trade has predominantly analyzed the determinants of trade flow durations using Cox proportional hazards models. The purpose of this paper is to show why it is inappropriate to analyze the duration of trade with continuous-time models such as the Cox model, and to propose alternative discrete-time models which are more suitable for estimation. Briefly, the
Fuel cell performance using a phosphonated polysulphone ionomer (PSUgPVPA) in the PEM cathode
Thoughts on implants and contact allergy
Remission achieved after 2 years treatment with low-dose prednisolone in addition to disease-modifying anti-rheumatic drugs in early rheumatoid arthritis is associated with reduced joint destruction still present after 4 years: an open 2-year continuation study
Objective: To evaluate if remission induced by low-dose prednisolone during the first 2 years of rheumatoid arthritis (RA) in the BARFOT glucocorticoid (GC) study had a sustained effect on radiological damage for a total of 4 years. Methods: A total of 150 of 211 eligible patients with RA who had been randomised to the 7.5 mg prednisolone group ( P) or no prednisolone group (NoP) in addition to th
Models for road surface roughness
This study focuses on the statistical description and analysis of road surface irregularities that are essential for heavy-vehicle fatigue assessment. Three new road profile models are proposed: a homogenous Laplace moving average process, a non-homogenous Laplace process and a hybrid model that combines Gaussian and Laplace modelling. These are compared with the classical homogenous Gaussian proc
Information activities and appropriation in teacher trainees’ digital, group-based learning
Introduction: This paper reports results from an ethnographic study of teacher trainees’ information activities in digital, group-based learning and their relation to the interplay between use and appropriation of digital tools and the learning environment. Method. The participants in the present study are 249 pre-school teacher trainees in Sweden. Three key informants and their teams were followe
Considering fungal:bacterial dominance in soils - Methods, controls, and ecosystem implications
An expectation in soil ecology is that a microbial communities' fungal:bacterial dominance indicates both its response to environmental change and its impact on ecosystem function. We review a selection of the increasing body of literature on this subject and assess the relevance of its expectations by examining the methods used to determine, the impact of environmental factors on, and the expecte
Dual-VT 4kb Sub-VT Memories with <1 pW/bit Leakage in 65 nm CMOS
Two standard-cell based memories (SCMs) for op- eration in the subthreshold (sub-VT) region are presented. The SCMs accomplish the task of robust sub-VT storage and fill the gap of missing sub-VT memory compilers. The storage elements (latches) of these SCMs are custom-designed cells using a dual- VT approach to balance timing. Additionally, two read-logic styles are presented: 1) a segmented 3-st
Large-scale monitoring of waders on their boreal and arctic breeding grounds in northern Europe
Large-scale and population-wide monitoring of waders on their boreal and arctic breeding grounds has hitherto been lacking, mainly because logistics are truly challenging in regions with few ornithologists, vast areas and few roads. In Norway, Sweden and Finland (here 'Fennoscandia') there are now national monitoring schemes in place, aimed at tracking all bird species, which allows trends to be e
Remotely-sensed, nocturnal, dew point correlates with malaria transmission in Southern Province, Zambia: a time-series study
Background: Plasmodium falciparum transmission has decreased significantly in Zambia in the last decade. The malaria transmission is influenced by environmental variables. Incorporation of environmental variables in models of malaria transmission likely improves model fit and predicts probable trends in malaria disease. This work is based on the hypothesis that remotely-sensed environmental factor
Baltic-Finns and Scandinavians : Comparative-Historical Linguistics and the Early History of the Nordic Region
The study investigates how the early nineteenth century invention of comparative-historical linguistics affected European ethnohistoric thought, and how this process altered ethnohistorical research on the early, pre-Christian history of the Nordic region. The case study of the Nordic region (Denmark, Iceland, Norway, Sweden, Finland and Estonia) includes the discipline histories of Finno-Ugric st