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The bromodomain and extra-terminal (BET) protein BRD4 regulates gene expression via recruitment of transcriptional regulatory complexes to acetylated chromatin. Like other BET proteins, BRD4 contains two bromodomains, BD1 and BD2, that can interact cooperatively with target proteins and designed ligands, with important implications for drug discovery. Here, we used nuclear magnetic resonance (NMR)

We revisit our rope model for string fragmentation that has been shown to give a reasonable description of strangeness and baryon enhancement in high-multiplicity pp events at the LHC. A key feature of the model is that the enhancement is driven by the increased string tension due to strings overlapping in dense systems. By introducing an improved space–time picture for the overlap between fragmen

A new landstreamer system has been developed that provides high resolution imaging from near surface to medium depths. The system is comprised of a combination three-component array to acquire SH data for near surface and a single component array to acquire typical P-wave data at depth. The first application of the system is being carried out for a groundwater mapping project where detailed knowleA new landstreamer system has been developed that provides high resolution imaging from near surface to medium depths. The system is comprised of a combination three-component array to acquire SH data for near surface and a single component array to acquire typical P-wave data at depth. The first application of the system is being carried out for a groundwater mapping project where detailed knowle

Purpose: Visual functioning evaluated by the Catquest-9SF questionnaire has shown to be a valid measure for assessing a patient's prioritization for cataract surgery. This study adapted Catquest-9SF for visual function outcomes post uni-lateral cataract surgery or bi-lateral cataract surgery. Methods: Visual functioning was assessed before and after uni-lateral or bi-lateral cataract surgery using

Seismic refraction imaging is a technique that has seen an increase of applications in engineering during recent years. In the work presented here a case of refraction tomography in the city of Copenhagen is discussed. The survey included two modalities; 1. a surface survey where 13.9 kilometers of crooked lines along segments of the planned underground metro were mapped, 2. borehole “walk-away” sSeismic refraction imaging is a technique that has seen an increase of applications in engineering during recent years. In the work presented here a case of refraction tomography in the city of Copenhagen is discussed. The survey included two modalities; 1. a surface survey where 13.9 kilometers of crooked lines along segments of the planned underground metro were mapped, 2. borehole “walk-away” s

This work presents a case where a combination of electromagnetics (EM61), refraction seismic surveys and a geotechnical survey allowed a detailed mapping of the near surface at a soil depot.This work presents a case where a combination of electromagnetics (EM61), refraction seismic surveys and a geotechnical survey allowed a detailed mapping of the near surface at a soil depot. Such results together with knowledge of the glacial overburden and groundwater potential enabled accurate determination of digging depth within the area, and thereby optimizing extension of the soil depot. The

We study the role of intermediate excitations of Rydberg states as an example of Kuchiev's "atomic antenna"in above-threshold ionization of xenon, in particular their effect on the coherence between the spin-orbit-split states of the ion. We focus on the case of a laser frequency close to resonant with the spin-orbit splitting, where a symmetry (parity) argument would preclude any coherence being

Fires are a major hazard resulting in high monetary costs, personal suffering, and irreplaceable losses. The consequences of a fire can be mitigated by early detection systems which increase the potential for successful intervention. The number of false alarms in current systems can for some applications be very high, but could be reduced by increasing the reliability of the detection system by us

This paper proposes a critical analysis of the innovative jurisprudential approaches taken by the Inter-American Court of Human Rights in integrating the content and scope of protection of the human rights of children, in the context of migration processes. How might one provide an effective protection to unaccompanied children that enter irregularly into the territory of a given country, when the

Refugee integration is a highly politicised topic and is rarely analysed from a legal perspective. This contribution aims to address this gap by tracing the potential of the right to be integrated in legal terms, analysing its legal sources in European human rights law, and in European Union (EU, the Union) law, using a doctrinal method. It answers the question: is there a state obligation to prov

Technological advances have made diagnosis of heart rhythm disturbances much easier, with a wide variety of options, including single-lead portable devices, smartphones/watches to sophisticated implantable cardiac monitors, allowing accurate data to be collected over different time periods depending on symptoms frequency. This review provides an overview of the novel and existing heart rhythm test

ObjectivesThe aim of this study was to investigate the potential correlation between muscle mass/muscle quality and risk of complications or recurrence in patients presenting with acute uncomplicated diverticulitis. It was also to study if low muscle mass/quality correlated to prolonged hospital stay.Materials and methodsThe study population comprised 501 patients admitted to Helsingborg Hospital