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An anti-estradiol antibody with improved specificity is searched for by combining steroid analog binding studies, mutant antibodies obtained from a phage-display library and structural modeling. Three-dimensional models for the anti-estradiol antibody 57-2 were constructed by comparative model building. Estradiol and analogs were docked into the combining site and molecular dynamics simulation was
The overall aim of this thesis was to investigate families’ experiences when a child is diagnosed as having type 1 diabetes, and at one and three years after diagnosis. Since childhood health and the circumstances around it in the family have been shown to have a lasting impact on adult health and circumstances, an additional aim was to examine the long-term effect of childhood diabetes on educati
Popular Abstract in Swedish Tidstrender i prevalens, incidens och mortalitet följdes för 15000 diabetespatienter under 1991-2005. Kliniska fynd, C-peptidanalyser och öcellsantikroppar jämfördes med avseende på förmågan att särskilja typ 1 från typ 2 diabetes och faktorer som påverkade prognosen undersöktes. Incidens och ålder vid insjuknandet förhöll sig oförändrade över tid, men prevalensen ökadTime trends in prevalence, incidence and mortality was followed in 15000 diabetic patients in 1991?2005. Clinical findings, C-peptide protocols, and islet antibodies were compared in their ability to distinguish type 1 from type 2 diabetes, and factors associated with the prognosis of diabetes were explored. The incidence and the age at onset remained stable but the prevalence of diabetes increas
Our aim was to describe voluntary associations for patients with cancer in Sweden (n=108) and their activities, type and extent of member support, and the associations' collaboration with the health care system. A specially constructed questionnaire with structured and open questions was used for the investigation. The frequency of answers was 89%. The results show in the broadest sense that the a
Effects of hypoxia and glucose-free solution on the isolated rat portal vein were studied. Decrease of extracellular PO2 below 50 mm Hg caused graded inhibition of spontaneous mechanical activity; below 7 mm Hg, inhibition was complete in most preparations. Contracture force of depolarized portal vein was less sensitive to decreases in PO2. Responses to noradrenaline at all concentrations were mar
Allergy and autoimmunity are both examples of deregulated immunity characterized by inflammation and injury of targeted tissues that have until recently been considered disparate disease processes. However, recent findings have implicated mast cells, in coordination with granulocytes and other immune effector cells, in the pathology of these two disorders. The BioBreeding (BB) DRlyp/lyp rat develo
Background. A spectrum of cutaneous human papillomaviruses (HPVs) is detectable in nonmelanoma skin cancers, as well as in healthy skin, but the significance that the presence of these types of HPV DNA has for the pathogenesis of skin cancer remains unclear. Methods. We studied 349 nonimmunosuppressed patients with skin lesions (82 with squamous cell carcinomas, 126 with basal cell carcinomas, 49
A high excess mortality is well described after hip fracture. Deaths are in part related to comorbidity and in part due directly or indirectly to the hip fracture event itself (causally related deaths). The aim of this study was to examine the quantum and pattern of mortality following hip fracture. We studied 160,000 hip fractures in men and women aged 50 years or more, in 28.8 million person-yea
The dementia with Lewy bodies (DLB) Consortium has revised criteria for the clinical and pathologic diagnosis of DLB incorporating new information about the core clinical features and suggesting improved methods to assess them. REM sleep behavior disorder, severe neuroleptic sensitivity, and reduced striatal dopamine transporter activity on functional neuroimaging are given greater diagnostic weig
This thesis treats controller design and tuning for systems with two input signals and two output signals in the process industry. Two design methods that can be combined to form a core in an algorithm for automatic design and tuning for the considered systems are presented. The proposed controller consists of a decoupler and a diagonal PID controller. This implies that the two main problems to so
Aim: To study whether excess hospitalization occurs among certain groups of children born in Sweden to immigrant parents. Methods: The study was based on linkage of the Swedish Medical Birth Register 1987-1997 and the Swedish Hospital Discharge Register 1987-1998. Results: Among children whose parents were of Swedish nationality excess hospitalization was found for children of young mothers, parit
No abstract available
Background: A trial fibrillation (AF) is a common problem in pacemaker patients. We conducted a prospective observational study in patients paced for bradycardia with associated paroxysmal or persistent AF, to determine whether P-wave duration may stratify patients at higher risk for AF recurrences and AF-related hospitalizations. The patients were evaluated for the prevalence, cause, and predicto
Deactivation of SCR catalysts applied in bio fuel plants is a major problem due to higher amounts of potassium in bio fuel compared to other fuels. Regeneration of deactivated catalysts seems to be a promising way for minimising the total cost of bio fuel plants and great potential lies in finding regeneration processes that can be used commercially. The first applied regeneration method was washi
The Hartree-Fock-Bogoliubov (HFB) equation for deformed nuclei in a simplified model is solved in coordinate space with correct asymptotic boundary conditions, in order to study the pair correlation in nuclei close to the neutron drip line. The eigenphase formalism is applied, when the upper components of HFB radial wave functions are continuum wave functions. Calculated occupation probabilities o
Global regulatory circuits together with more specific local regulators play a notable role when cells are adapting to environmental changes. Lactococcus lactis is a lactic acid bacterium abundant in nature fermenting most mono- and disaccharides. Comparative genomics analysis of the operons encoding the proteins and enzymes crucial for catabolism of lactose, maltose and threhalose revealed an obv
