Published 7 November 2020 In a recent population-based study, an elevated risk of the Metabolic syndrome (MetS) and type 2 diabetes was found in childless men compared to those who have fathered one or more children. Therefore, by using a larger cohort of more than 22 000 men from the Malmo Preventive Project (MPP) we aimed to expand our observations in order to evaluate the metabolic profile of c

https://www.lupop.lu.se/article/male-childlessness-independent-predictor-risk-cardiovascular-and-all-cause-mortality-population - 2025-07-05

Published 8 November 2020 Hemopexin and α1-microglobulin act as scavengers to eliminate free heme-groups responsible for hemoglobin-induced oxidative stress. The present study evaluated maternal and fetal plasma concentrations of these scavengers in the different phenotypes of placenta-mediated disorders. Singleton pregnancies with normotensive fetal growth restriction [FGR] (n = 47), preeclampsia

https://www.lupop.lu.se/article/hemopexin-and-a1-microglobulin-heme-scavengers-differential-involvement-preeclampsia-and-fetal - 2025-07-05

Published 8 November 2020 Welders are exposed to high levels of metal particles, consisting mainly of iron and manganese (Mn) oxide. Metal particles, especially those containing Mn can be neurotoxic. In this exploratory study, we evaluated associations between welding and expression of 87 putative neurology-related proteins in serum in a longitudinal approach. The study cohort from southern Sweden

https://www.lupop.lu.se/article/exposure-mild-steel-welding-and-changes-serum-proteins-putative-neurological-function-longitudinal - 2025-07-05

Published 4 November 2020 TheLIH is looking for new leadership to structure the Department of PopulationHealth focusing on multiple determinants of health and disease beyond ‘omics’,with an emphasis on social and environmental determinants that drive healthoutcomes and health inequities in the population and patient cohorts. Read more at https://www.lih.lu/jobs/detail/director-of-department-of-pop

https://www.lupop.lu.se/article/director-department-population-health-un1020 - 2025-07-05

Published 5 November 2020 The extraordinary effort to speed the development of treatments and vaccines in response to the COVID-19 pandemic has put into sharp relief the need for the global science community to share scientific data openly. As the world’s largest funder of biomedical research, NIH is addressing this need with a new NIH Policy for Data Management and Sharing. This policy requires r

https://www.lupop.lu.se/article/statement-final-nih-policy-data-management-and-sharing - 2025-07-05

Published 9 November 2020 Har Du eller någon nära anhörig genomgått så kallad mikrovaskulär lambåkirurgi i huvud-halsområdet vid Skånes Universitetssjukhus i Lund under åren 1989-2019? I så fall ämnar vi undersöka Din/Din anhörigs patientjournaler som del av en forskningsstudie. Läs mer här https://www.lupop.lu.se/preoperativ-riskskattning-vid-stor-huvud-halski…

https://www.lupop.lu.se/article/preoperativ-riskskattning-vid-stor-huvud-halskirurgi - 2025-07-05

Published 9 November 2020 Insomnia affects up to one in four adolescents and has been shown to have a negative impact on their mental and physical health. This study aimed to investigate the association between insomnia, academic performance, self-reported health, physical activity, school start time, and substance use among adolescents. Read more at https://pubmed.ncbi.nlm.nih.gov/32899407/

https://www.lupop.lu.se/article/insomnia-relation-academic-performance-self-reported-health-physical-activity-and-substance-use - 2025-07-05

Published 10 November 2020 The study comprised women born 1923–1950 living in Malmö city, Sweden, 1991–1996, and enrolled for a prospective population cohort study. Occupational exposure to various chemicals was assessed from job-exposure matrices. An extensive set of individual data on hormonal breast cancer risk factors were collected via a baseline questionnaire and used for confounding control

https://www.lupop.lu.se/article/postmenopausal-breast-cancer-and-occupational-exposure-chemicals-0 - 2025-07-05

Published 10 November 2020 The current study aimed to assess the factors associated with HRQoL and HU among Patients with diabetes in Zabol, Southeast Iran. Methods: Among patients referred to Zabol city diabetes clinic, a total of 213 consecutive patients 18 years and older consent to participate in the study in 2015. The Persian version of EuroQol-5D-3L (EQ-5D-3L) using the UK preference weights

https://www.lupop.lu.se/article/health-related-quality-life-and-health-utility-among-patients-diabetes-zabol-southeast-iran - 2025-07-05

Published 11 November 2020 Human episodic memory critically depends on subregions of the medial temporal lobe, which are part of functional brain systems such as the anterior-temporal and the posterior-medial system. Here we analysed how Alzheimer’s pathology affects functional connectivity within these systems. Data from 256 amyloid-β-negative cognitively unimpaired, 103 amyloid-β-positive cognit

https://www.lupop.lu.se/article/medial-temporal-lobe-connectivity-and-its-associations-cognition-early-alzheimers-disease - 2025-07-05

Published 11 November 2020 A growing body of evidence suggests that the dysregulation of neuronal iron may play a critical role in Alzheimer’s disease. Recent MRI studies have established a relationship between iron accumulation and amyloid-β aggregation. The present study provides further insight demonstrating a relationship between iron and tau accumulation using magnetic resonance-based quantit

https://www.lupop.lu.se/article/relationship-between-cortical-iron-and-tau-aggregation-alzheimers-disease - 2025-07-05

Published 12 November 2020 Perinatal characteristics are associated with subsequent risk of several chronic diseases. Previous studies regarding endometriosis were based on small samples and retrospective data and were limited by unmeasured confounding bias, leading to conflicting and inconclusive findings. We investigated the associations of maternal and birth characteristics with risk of endomet

https://www.lupop.lu.se/article/associations-perinatal-characteristics-endometriosis-nationwide-birth-cohort-study - 2025-07-05

Published 12 November 2020 The question of whether having a family history of prostatic borderline or in situ neoplasia (PBISN) is associated with an increased risk of invasive prostate cancer (PCa) or death from PCa remains unanswered. The objective of the current study was to provide an evidence‐based risk estimation for the relatives of patients with PBISN. Read more at https://acsjournals.onli

https://www.lupop.lu.se/article/risk-invasive-prostate-cancer-and-prostate-cancer-death-relatives-patients-prostatic-borderline-or - 2025-07-05

Published 13 November 2020 The authors examined the association between alcohol use disorder (AUD) and risk of suicide, before and after accounting for psychiatric comorbidity, and assessed the extent to which the observed association is due to a potentially causal mechanism or genetic and familial environmental confounding factors that increase risk for both. Read more at https://ajp.psychiatryon

https://www.lupop.lu.se/article/alcohol-use-disorder-and-risk-suicide-swedish-population-based-cohort - 2025-07-05

Published 13 November 2020 In all, 381 (0.2 %) children were assigned a cerebral palsy diagnosis. Among term children, maternal preobesity/obesity, small for gestational age, malformations, induction, elective and emergency caesarian section, Apgar <7 at 5 min and admission to neonatal care were significantly associated with cerebral palsy (all p values<0.05). Among children born moderately or lat

https://www.lupop.lu.se/article/associations-between-antenatal-and-perinatal-risk-factors-and-cerebral-palsy-swedish-cohort-study - 2025-07-05

Published 14 November 2020 Obesity induces molecular changes that may favor tumor progression and metastatic spread, leading to impaired survival outcomes in breast cancer. Adenylate cyclase-associated protein 1 (CAP1), an actin regulatory protein and functional receptor for the obesity-associated adipokine resistin, has been implicated with inferior cancer prognosis. Here, the objective was to in

https://www.lupop.lu.se/article/effects-tumor-specific-cap1-expression-and-body-constitution-clinical-outcomes-patients-early-breast - 2025-07-05

Published 14 November 2020 Group A streptococci (GAS) are known to cause serious invasive infections, but little is known about outcomes when patients with these infections are admitted to intensive care. We wanted to describe critically ill patients with severe sepsis or septic shock due to invasive GAS (iGAS) and compare them with other patients with severe sepsis or septic shock. Read more at h

https://www.lupop.lu.se/article/morbidity-and-mortality-critically-ill-patients-invasive-group-streptococcus-infection-observational - 2025-07-05

Published 15 November 2020 Pre-hospital circumstances, cardiac arrest characteristics, comorbidities and clinical status on admission are strongly associated with outcome after out-of-hospital cardiac arrest (OHCA). Early prediction of outcome may inform prognosis, tailor therapy and help in interpreting the intervention effect in heterogenous clinical trials. This study aimed to create a model fo

https://www.lupop.lu.se/article/artificial-neural-networks-improve-early-outcome-prediction-and-risk-classification-out-hospital - 2025-07-05

Published 15 November 2020 The etiology of type-2 diabetes is only partly known, and a possible role of prenatal stress in programming offspring for insulin resistance has been suggested by animal models. Previously, we found an association between prenatal stress and type-1 diabetes. Here we examine the association between prenatal exposure to maternal bereavement during preconception and pregnan

https://www.lupop.lu.se/article/prenatal-exposure-bereavement-and-type-2-diabetes-danish-longitudinal-population-based-study - 2025-07-05

Published 16 November 2020 Problem gambling is a public health issue and its comorbidity with other health conditions may provide an opportunity for screening in healthcare settings; however, a high level of uncertainty and a lack of research in the field remains. The objective of this study is to investigate potential associations between problem gambling and numerous other health conditions, inc

https://www.lupop.lu.se/article/problem-gambling-associations-comorbid-health-conditions-substance-use-and-behavioural-addictions - 2025-07-05