The Molecular Signaling Special Interest Group focus on genetics and their effects on different neurodegenerative disorders. Everything from gene expression, gene therapy, and epigenetic mechanisms is considered. In substantia nigra, neurons expressing Calretinin seem to be more resistant to damage. Photo: Lautaro Belfiori. This SIG combines a broad range of research topics. These include genetics

https://www.multipark.lu.se/molecular-signaling-neurodegenerative-diseases - 2025-07-11

The MESO QuickPlex SQ 120 is a multiplexing plate reader using high-performance, electrochemiluminescence (ECL) immunoassays for detecting biomarkers. The instrument allows for precise quantitation of single or multiple, low to elevated abundance analytes, in a single sample. The MULTI-ARRAY technology has increased dynamic range, improved sensitivity, reduced sample volume and reagent requirement

https://www.multipark.lu.se/infrastructures/meso-quickplex - 2025-07-11

MultiPark supports up to 50% of a clinical bioinformatician, for projects within the aims of MultiPark.The bioinformatician works with bioinformatic analyses of genetic data from high throughput genetic sequencing from patients and families with Parkinson disease, dementia, other movement disorders and cerebrovascular disorders. Tasks/expertise include the identification of disease-associated gene

https://www.multipark.lu.se/infrastructures/clinical-bioinformatics-infrastructure - 2025-07-11

MultiPark NGS database is completed and available to interested MultiPark researchers. Data from whole exome sequencing of 287 clinically well-characterized Parkinson disease patients from southern Sweden is now available in the MultiPark NGS database. Patients had been recruited within the PARkinsonLUnd (PARLU) study and MultiPark’s biobank sample collection(MPBC). Great care has been taken to en

https://www.multipark.lu.se/infrastructures/ngs-database-infrastructure - 2025-07-11

High-content analysis system High content screening (HCS) / Analysis (HCA) enables automated acquisition, visualization and quantification of a large number of images and can capture and measure dynamic processes, such as migration and/or changes in morphology, expression pattern and/or intensity.This system featuresAutomated fluorescence and brightfield microscopyWidefield and confocal (spinning

https://www.multipark.lu.se/infrastructures/operetta-cls - 2025-07-11

According to a decision made by the MultiPark board, the infrastructures have been evaluated. Kajsa Paulsson, one of the external board members, has been responsible for this process. Read the general conclusions of the evaluation report from November 2022 here:  Evaluation of the MultiPark Research Infrastructures Nov 2022.pdf

https://www.multipark.lu.se/infrastructures/infrastructure-evaluation - 2025-07-11

Read about our latest scientific discoveries See all publications from our research groups here. 

https://www.multipark.lu.se/research/publications - 2025-07-11

Visit MultiPark Café (link to Swedish event site) MultiPark Café MultiPark Café is a series of popular science lectures (in Swedish) where our researchers present their latest discoveries. The seminars are aimed at patient associations and the general public and each evening has a specific theme.More information about these events can be found on our Swedish homepage. Listen to Meet our scientists

https://www.multipark.lu.se/outreaching-activities-0 - 2025-07-11

As of January 2025, the sequencing services previously provided by the MultiPark Neuroscience Omics Facility (formerly known as the Next Generation Sequencing Facility) can be accessed by directly contacting the Center for Translational Genomics at Lund University (https://www.ctg.lu.se/ctg-center-translational-genomics).Some equipment funded by MultiPark for use in the former facility will still

https://www.multipark.lu.se/infrastructures/ngs-equipment - 2025-07-11

PET imaging of the brain is a powerful method to study physiology and disease in the living brain of humans as well as animal models. The unit for nuclear medicin at Skåne University Hospital provides radioligands for both experimental and clinical use. Besides 18F-FDG, they also synthesize a range of other PET tracers such as ligands binding to the dopamine transporter, tau filaments or β-amyloid

https://www.multipark.lu.se/infrastructures/pet-ligand-radiosynthesis-platform - 2025-07-11

High content screening (HCS)/Analysis (HCA) Left: photo of the Plate Runner HD from Trophos. Upper right: whole well image of culture well (96 well plate format) containing human induced pluripotent stem cells grown on mouse feeders, stained for pluripotent markers NANOG (red) and OCT4 (green). The cell nuclei is stained with DAPI (blue). Lower right: whole well image of culture well (96 well plat

https://www.multipark.lu.se/infrastructures/plate-runner-platform - 2025-07-11

Quanterix SR-X Ultra-Sensitive Biomarker Detection System The Simoa Analyzer is particularly useful for measurements of biomarkers at ultra-low levels.The Simoa Analyzer system features:Single molecule array technique for high sensitivity and broad dynamic rangeCombined digital and analog immunoassay dynamic range is >4 logsA range of sample types include serum, plasma, cerebrospinal fluid, urine,

https://www.multipark.lu.se/infrastructures/simoa-analyzer - 2025-07-11

MultiPark's podcast series In this podcast series, young MultiPark researchers interview our research group leaders about their academic journey and main scientific focus. Emma Nyberg and Lluís Camprubí Ferrer, the Young MultiPark working group members, carry out the interviews.    Listen to the introduction episode of our podcast series here:  E0_MultiPark's podcast series Meet Our Scientists Mul

https://www.multipark.lu.se/meet-our-scientists - 2025-07-11

Planning Introduction to Simoa: all users that require assistance with how to operate the microplate washer, shaker and SR-X reader, please contact XXX For assistance in assay choice or development, contact Quanterix. For overview of assay kits and custom-developed assays, go to links below: Quanterix Simoa Assay Kits  Quanterix Simoa Homebrew custom assay development Register on the Quanterix cus

https://www.multipark.lu.se/services-simoa - 2025-07-11

Young MultiParker's image competition of 2023 We're excited to announce our upcoming "Brain in Picture" photo contest! The theme of the competition: The challenge is to capture the essence of brain research in a single snapshot. We're looking for images that showcase neuroscience's beauty, complexity, and wonder (It could be immune staining of brain cells, MRI, PET, or other things linked to your

https://www.multipark.lu.se/brain-picture - 2025-07-11

This group focuses on acquired brain injuries, such as stroke and their relation to neurodegeneration. We explore adaptive plasticity processes found in Alzheimer’s disease, Parkinson’s disease, and other neurodegenerative diseases. A 7 Tesla MRI of a human brain. Picture: Tekla Kylkilahti, Lundgaard group. Other examples of acquired brain injuries of interest to our group are traumatic brain inju

https://www.multipark.lu.se/acquired-brain-injuries-and-their-links-neurodegeneration - 2025-07-11

How does it work? Principle of Simoa - single molecule array technology Workflow    

https://www.multipark.lu.se/technical-information-meso-quickplex - 2025-07-11

This group focuses on the development and implementation of biomarkers that are associated with neurodegenerative disorders and reflects other conditions of the brain. Examined mediums include CSF, blood, skin biopsies, and cells. Biomarkers of interest to our group are linked to:Alzheimer’s disease and other neurodegenerative disordersGeneral neurodegenerationAcute and chronic brain injury includ

https://www.multipark.lu.se/development-and-implementation-fluid-biomarkers-neurodegenerative-diseases-0 - 2025-07-11

Grant Manager at MultiPark Grant Manager at MultiParkWe are currently seeking a committed and proactive Grant Manager to support us in identifying key funding opportunities and applying for major research grants, particularly at the European level. We also require support in identifying and securing large-scale funding to establish national competence centres and graduate schools. You will routine

https://www.multipark.lu.se/open-positions - 2025-07-11

This project is focusing on how the exchange of greenhouse gases between the biosphere and the atmosphere is affected by different kinds of disturbance, both natural disturbances such as storms and by different forest management practices. Disturbance effects in Boreal ForestsDisturbance usually leads to increased availability of organic material and increased decomposition of soil organic matter,

https://www.nateko.lu.se/research/biosphere-atmosphere-interactions/lu-fluxes-biosphere-atmosphere-interaction-research/effects-forest-management-and-natural-disturbance-greenhouse-gas-exchange - 2025-07-11