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PURPOSE: Nucleophosmin 1 (NPM1) mutations are associated with a favorable prognosis in acute myeloid leukemia (AML) when an internal tandem duplication (ITD) in the fms-related tyrosine kinase 3 gene (FLT3) is absent (FLT3-ITDneg) or present with a low allelic ratio (FLT3-ITDlow). The 2017 European LeukemiaNet guidelines assume this is true regardless of accompanying cytogenetic abnormalities. We

Site-specific land management practice taking into account variability in maize yield gaps (the difference between yields in the 90th percentiles and other yields on smallholder farmers’ fields) could improve resource use efficiency and enhance yields. However, the applicability of the practice is constrained by inability to identify patterns of resource utilization to target application of resour

Whether cyclodextrins (CDs) self-aggregate or not in solution is an interesting and timely scientific question. Yet, we are far from a scientific consensus as regards the nature of the phenomenon. Those who are in favor of the formation of CD aggregates justify the phenomenon by the presence of H-bonds, occurring between the hydroxyl groups located at both rims of cyclodextrins. To gain further in

Weakly-coupled TeV-scale particles may mediate the interactions between normal matter and dark matter. If so, the LHC would produce dark matter through these mediators, leading to the familiar “mono-X” search signatures, but the mediators would also produce signals without missing momentum via the same vertices involved in their production. This document from the LHC Dark Matter Working Group sugg

The International Association of Fire Safety Science (IAFSS) is comprised of members from some 40 countries. This paper presents the Association's thinking, developed by the Management Committee, concerning pressing research needs for the coming 10 years presented as the IAFSS Agenda 2030 for a Fire Safe World. The research needs are couched in terms of two broad Societal Grand Challenges: (1) cli

This paper examines the rights of users of health, fitness and wellness e-services concerning the use, re-use and conservation of their health and health related data. In particular, it will analyse the scope and limits of the ‘right to be forgotten’ recently codified under Article 17 in the General Data Protection Regulation. It will address generally patience records and clinical trial data, and

Aims: To study the frequency, etiology, and premortal abnormalities in exercise-related sudden cardiac death (SCD) in the young in Sweden. Methods: All subjects with SCD in 10–35-year olds in Sweden during 2000–10, were included (n = 514). Information about each case was retrieved from death certifications, autopsy- and medical records. The number of SCD in athletes was compared to national figure

Background: Biomarker-based risk predictions of dementia in people with mild cognitive impairment are highly relevant for care planning and to select patients for treatment when disease-modifying drugs become available. We aimed to establish robust prediction models of disease progression in people at risk of dementia. Methods: In this modelling study, we included people with mild cognitive impair

Tunnel Field Effect Transistor (TFET), based on band-to-band tunneling, overcomes the thermal limit (subthreshold slope (S) > 60 mV/decade) of the MOSFETs by filtering the high-energy Fermi tail, thereby allowing a substantial reduction of supply voltage and power consumption. Despite the steep slope behavior, TFETs can suffer from ambipolarity wherein carriers tunnel into the channel at both high

Background: Hippocampal volume reduction is a well replicated finding in schizophrenia. Evidence indicates a contribution of genetic and environmental factors, especially the influence of obstetric complications to this volume reduction. The aim of this study was to compare hippocampal volume of schizophrenic patients as well as and their relatives with control subjects and to quantify the additio

The digital cellular systems era started about thirty years ago with the release of the first digital cellphones. These first digital cellphones were very different from today’s slim and esthetic cellular pocket computers. They were not mass-produced in million units a day, and they were designed for radio performance rather than appearance. Today, all components are integrated inside the mobile p

Recension av Nils Uddenberg, Skallmätaren. Gustaf Retzius – hyllad och hatad.

Although automation has been introduced in all areas of public life, what seems to be missing is a reflection at the organizational or societal level about a policy of automation. By this we intend appropriate declarations made at the level of rationale, future plans and strategies to achieve intended goals and most importantly how those achievements will impact on various aspects of societal life

Although automation has been introduced in all areas of public life, what seems to be missing is a reflection at the organizational or societal level about a policy of automation. By this the authors intend appropriate declarations made at the level of rationale, future plans and strategies to achieve intended goals and most importantly how those achievements will impact on various aspects of soci

This article focuses on videography as a method for conducting research, as a means of communicating findings about tags and tagging to the public, and an opportunity to re-evaluate previously-collected empirical material.Based on ongoing explorative videographic research, the author discusses how the video medium can be used to go beyond the mere visual representation of tags as singular expressi

The use of social media technologies in organizations has introduced novel ways of collaboration, communication, and knowledge sharing. In this respect, the present study is concerned with examining the use of one type of social media, the wiki technology, by members of several professional communities of practice to collaborate and share knowledge with each other. As such, it seeks to identify an