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Objective: To investigate the possible disease-association and pathogenic mechanisms of heterozygous PINK1 mutations from a genetic, functional, and structural perspective. Background: It has been postulated that heterozygous mutations in recessive PD genes may increase disease risk. In particular, the PINK1 p.G411S mutation has been reported in families with dominant inheritance patterns, suggest
Corrosion of steel reinforcement is a large and increasing problem for reinforced concrete structures. Simple and reliable assessment methods are required to use the full capacity of existing infrastructure. In this paper, a reliable engineering assessment method is outlined. A model for anchorage has been developed and verified against a large database of bond tests. Also the influence of corrosi
Recension av avhandlingen “Den ofrivilla lyssnaren” av Olle StenbäckReview of the dissertation “Den ofrivilla lyssnaren” by Olle Stenbäck
Teachers’ perceptions of organizational communication were assessed using a tailored questionnaire, sampling 401 primary and lower secondary school teachers from two municipalities in Sweden. Overall, the teachers were satisfied with the workplace communication climate, the communication structure, and collegial communication; however, a lack of time for communication was reported. Using a job dem
Modern computing systems are often formed by multiple components that interact with each other through the use of shared resources (e.g., CPU, network bandwidth, storage). In this paper, we consider a representative scenario of one such system in the context of an Internet of Things application. The system consists of a network of self-adaptive cameras that share a communication channel, transmitt
New nanoarchitectures can be built from polycyclic aromatic hydrocarbons (PAHs) by exploiting the capability of some metal surfaces for inducing cyclodehydrogenation reactions. This bottom-up approach allows the formation of nanostructures with a different dimensionality from the same precursor as a consequence of the diffusion and coupling of the PAHs adsorbed on the surface. In this work we pres
2,2-Bis(hydroxymethyl)butyric acid (BHMB) is an important multifunctional chemical for the emerging bio-based polymer industry. It can be produced from trimethylolpropane (TMP) by selective oxidation using growing cells of Corynebacterium sp. ATCC 21245. However, this process is limited by the low volumetric productivity and low concentration of the final product. In the present study, we performe
Silicon isotope ratios (expressed as δ30Si) in marine microfossils can provide insights into silica cycling over geologic time. Here we used δ30Si of sponge spicules and radiolarian tests from the Paleogene Equatorial Transect (Ocean Drilling Program Leg 199) spanning the Eocene and Oligocene (~50-23 Ma) to reconstruct dissolved silica (DSi) concentrations in deep waters and to examine upper ocean
Due to the scarcity of reliable palaeoecological and climatic proxy records from the Eastern Baltic covering the Holocene, there has been increased interest for multi-proxy studies in the region to detect local to regional environmental changes. The Čepkeliai wetland complex, SE Lithuania, provides an uninterrupted Holocene sediment sequence, which is used here to reconstruct palaeoenvironmental h
This article tests for wage discrimination in US manufacturing during the nineteenth century and in 2002 by estimating the female-to-male productivity ratio and comparing it to the wage ratio. This method will not identify all forms of discrimination, but will determine whether women were paid wages commensurate with their productivity. There was no significant difference between the wage ratio an
A 128kb ultra-low voltage SRAM, based on a leakage optimized single-WELL 7T bitcell in 28 nm FD–SOI technology is presented. An ideal power management scenario in a single supply system is achieved by permanently keeping the storage elements in the vicinity of the retention voltage. Performance and reliability is regained by boosting the voltage on critical nodes. The cost of voltage boost generat
