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Cellular and molecular cartography of muscle-invasive bladder cancer: Who benefits from neoadjuvant chemotherapy?

Muscle-invasive bladder cancer (MIBC) is characterised by significant molecular heterogeneity, with the tumour composition being further sculptured by local microenvironmental influences. This inherent complexity contributes to the divergent disease trajectories and the variable therapeutic susceptibility observed among patients. Consequently, there is an evident need for prognostic and predictive

Adult Hip Dysplasia - Prevalence and Consequence

Background: Adult hip dysplasia is one of the few potentially modifiable risk factors for hip osteoarthritis (OA). However, the prevalence of hip dysplasia and the strength of its association with OA are not fullyunderstood.Aims and methods:I. To determine the prevalence of hip dysplasia in a Swedish population and investigate whether the condition was mentioned in radiology reports. The center ed

Förändringar i tillförselpotential av långsiktigt hållbar skogsbiomassa

Bioenergi spelar idag en stor roll i det svenska energisystemet ur klimat- och energisäkerhetssynpunkt men vilken roll kan inhemsk bioenergi komma att spela framöver för att Sverige ska bli ett fossilfritt samhälle med nettonollutsläpp 2050? Syftet med denna rapport är att utifrån olika perspektiv beskriva hur tillförseln av inhemska skogsbaserade biobränslen kan komma att förändras under perioden

Integrated Model for Simulation and Regulation of Basin Water Resources Considering Water Quantity and Quality and Its Application

With the rapid process of urbanization, water conflicts between different water use industries and areas are increasing. Therefore, China has implemented the three-cordons system of water resources management since 2012, when how to make more reasonable regulation of water resources became an urgent problem in most areas of China. In this study, taking the Yuanhe River Basin as an example, an inte

Energioptimering och effektbalansering av växelvärmen i Trafikverkets hjälpkraftnät

I detta arbete har möjligheterna till att sänka maxeffekten på växelvärmen och dess energiförbrukning undersökts. En marknadsanalys gjordes av olika lösningar för att undersöka vilka befintliga lösningar som finns att tillgå. Sveriges växelvärmesystem jämfördes översiktligt med Danmarks och Norges för att undersöka eventuella skillnader och likheter som kan ligga till grund för förbättringsarbete.

Self-assembly properties of enzymatically treated oat oil

The enzymatic modification of natural oat oils enriched with polar lipids (PL), consisting mainly of equal mixture of phospholipids and galactolipids, offers a sustainable pathway to produce liquid crystalline phases (LCPs) with diverse structural arrangements, including micellar or bicontinuous cubic and hexagonal phases. These self-assembling lipid systems have potential applications in drug del

Chemical kinetics study of nitrogen-containing fuels in flames – experiments and modeling

Climate change is strongly linked to the quantity of carbon dioxide (CO2) released by burning fossil fuels, which contain carbon. To address the problem, ammonia (NH3) has recently gained significant attention as a potential alternative fuel due to its carbon-free nature, ease of storage, and good energy density. However, ammonia combustion in practical devices presents challenges, particularly it

Modelling reactive power support from a generic wind power plant

As the amount of wind power in electricity production increases it becomes more important that they are able to provide ancillary services to support power system stability. This thesis investigates how a generic wind power plant can provide reactive power for voltage support. To represent a generic wind power plant, the Western Electricity Coordinating Council’s generic Renewable Energy System mo

Cult Film Atmospheres : Audiences, exhibitors, and live cinema spaces

Kultfilmsevenemang som Den Dåliga Filmfestivalen (Göteborg, 2019 och 2023-2025) och B-Filmsklubben (Malmö) erbjuder unika atmosfärer för publiken som besöker dem. I Malmö och Göteborg anordnar biograferna regelbundet festivaler och fristående visningar av kultfilmer som band andra The Room, Birdemic, och Miami Connection. Kännetecknande för dessa upplevelser är den översvallande atmosfär som skapaCult film events like The Bad Film Festival (Gothenburg, 2019 and 2023-2025) and The B-Film Club (Malmö) offer unique atmospheres to audiences. In the two Swedish cities of Malmö and Gothenburg, exhibitors run regular festivals and standalone screenings of cult films such as The Room, Birdemic, Miami Connection, and others where an effervescent atmosphere is generated, often featuring audience par

Disability Anti-Discrimination Law: A Tool for Compliance or Path Towards Social Justice?

Drawing on vignette interviews, this article analyses the legal consciousness of disability anti-discrimination law of staff working with disability/accessibility resources in higher education in Sweden and the United States. In both countries, participants considered the law as the basis of their work, but differences were noticed regarding their views of the purpose of laws banning disability di

Bacteroides maternus sp. nov., a novel species isolated from human faeces

A novel bacterial strain, MSB163, was isolated from the stool sample of a healthy mother, 4 weeks after giving birth via vaginal delivery. Taxonomic identification tools revealed that MSB163 belongs to the genus Bacteroides, but it is distinct from any currently known species. The closest related species is Bacteroides cellulosilyticus strain BFG- 250, with an average nucleotide identity (fastANI)

Structural interplay in block copolymer-bile salt complexes : from globules to ribbons

The supramolecular structures resulting from the complexation between the neutral-cationic block copolymer poly(ethylene oxide)- block-poly(2-(trimethylammonium)ethyl methacrylate iodide) (PEO 114- b-PTMAEMAI 95) and the bile salt sodium deoxycholate (NaDC) were investigated by dynamic light scattering, small-angle X-ray scattering, cryogenic transmission electron microscopy and proton NMR techniq

Cyanobacterial Argonautes and Cas4 family nucleases cooperate to interfere with invading DNA

Prokaryotic Argonaute proteins (pAgos) from the long-A clade are stand-alone immune systems that use small interfering DNA (siDNA) guides to recognize and cleave invading plasmid and virus DNA. Certain long-A pAgos are co-encoded with accessory proteins with unknown functions. Here, we show that cyanobacterial long-A pAgos act in conjunction with Argonaute-associated Cas4 family enzyme 1 (ACE1). S

Utility of serum and urine leucine-rich alpha-2 glycoprotein 1 (LRG1) as predictors of appendicitis and complicated appendicitis in children

PurposeLeucine rich alpha-2 glycoprotein 1 (LRG1) has emerged as a promising biomarker for appendicitis, especially in pediatric patients. However, the currently available data are sparse, and the biomarker must be validated in more settings and compared to standard inflammatory markers. We aimed to evaluate the diagnostic and discriminative utility of serum and urine LRG1 in children with other c

Classifiers of anterior cruciate ligament status in female and male adolescents using return-to-activity criteria

Purpose: A lack of standardization exists for functional tasks in return-to-activity (RTA) guidelines for adolescents with anterior cruciate ligament injury (ACLi). Identifying the variables that discern ACLi status among adolescents is a first step in the creation of such guidelines following surgical reconstruction. This study investigated the use of classification models to discern ACLi status