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Large amounts of germline sequencing data have recently become available and we sought to compare these results with population-based family history data. Family studies are able to describe aggregation of any defined cancers in families. The Swedish Family-Cancer Database is the largest of its kind in the world, covering the Swedish families through nearly a century with all cancers in family mem
Background: Patients with obesity have a higher risk of complications after total knee arthroplasty (TKA). We investigated the change in weight 1 and 2 years post-Bariatric Surgery (BS) in patients that had undergone both TKA and BS as well as the risk of revision after TKA based on if BS was performed before or after the TKA. Methods: Patients who had undergone BS within 2 years before or after T
Evidence of air pollution exposure, namely, ambient particulate matter (PM), during pregnancy and an increased risk of autism in children is growing; however, the unique PM sources that contribute to this association are currently unknown. The aim of the present study was to investigate local, source-specific ambient PM exposure during pregnancy and its associations with childhood autism, specific
Background: Molecular analyses have shown that tumours diagnosed as supratentorial primitive neuro-ectodermal tumours of the central nervous system (CNS-PNETs) in the past represent a heterogenous group of rare childhood tumours including high-grade gliomas (HGG), ependymomas, atypical teratoid/rhabdoid tumours (AT/RT), CNS neuroblastoma with forkhead box R2 (FOXR2) activation and embryonal tumour
The pediatric extra-cranial tumor neuroblastoma displays a low mutational burden while recurrent copy number alterations are present in most high-risk cases. Here, we identify SOX11 as a dependency transcription factor in adrenergic neuroblastoma based on recurrent chromosome 2p focal gains and amplifications, specific expression in the normal sympatho-adrenal lineage and adrenergic neuroblastoma,
Background: Early blight, caused by the necrotrophic fungal pathogen Alternaria solani, is an economically important disease affecting the tuber yield worldwide. The disease is mainly controlled by chemical plant protection agents. However, over-using these chemicals can lead to the evolution of resistant A. solani strains and is environmentally hazardous. Identifying genetic disease resistance fa
Assessing effects of climate change on agricultural systems and the potential for ecological intensification to increase food security in developing countries is essential to guide management, policy-making and future research. ‘Push-pull’ technology (PPT) is a poly-cropping design developed in eastern Africa that utilizes plant chemicals to mediate plant–insect interactions. PPT application yield
Prydlig, proper och välskött - så tycks den perfekta trädgården se ut. Men när den kortklippta gräsmattan växte fram som ideal bland Europas välbärgade var övriga naturen vildare. I en tid av artutrotning och klimatförändringar finns det större behov än någonsin av otjämjda trädgårdar, skrive råtta forskare och landskapsarkitekter.In an era of species extinction and climate change, we should abandon the well-trimmed lawn and let gardens grow wilder, writes Anna Persson and other researchers and landscape architects on DN Debatt.
In Sweden men account for most new HIV cases, and little is known about the peer support needs of people living with HIV in Sweden. This qualitative study explored how recently diagnosed men perceive and experience peer support in Sweden. Purposively sampled from HIV patient organizations and infectious disease clinics throughout Sweden, data was collected through in-depth individual interviews wi
Question: what do the following statistics have in common? The second-largest (and growing) source of climate pollution in Europe. The leading killer of children in both the US and Europe. A principal cause of stress-inducing noise pollution and life-shortening air pollution in European cities. A leading driver of the widening gap between rich and poor urban residents.Answer: the vehicles on our s
This letter presents a radio frequency front-end (RFFE) for 5G new radio (NR) receivers operating in frequency range 1 (FR1). The core of this RFFE is a synthetic fourth-order Q -enhanced RF filter employing gm -boosting, noise-canceling, capacitive cross-coupling, and forward body-biasing techniques to achieve 1.7 to 6.4 GHz operating range and 1% to 40% adjustable fractional bandwidth (FBW). The
It is rare to encounter a scientific fact that stirs widespread debate and distrust quite like the matter of climate change.Despite consensus among climate specialists about a theory that is supported by a mountain of facts from the physical, natural, and cultural sciences, the debate continues to be perpetrated by politicians, industrialists, academics, and armchair scientists.When governments re
Denna rapport utgör en syntes av de sju projekt som finansierades inomNaturvårdsverkets och Havs- och vattenmyndighetens forskningssatsning inomområdet ekologisk kompensation som pågick 2018–2021. Syntesprojektet har utgått dels från slutrapporterna från de enskilda projekten, dels från myndigheternas uttryckta önskemål om belysning av vissa specifika aspekter inom tillämpningen av ekologisk kompeThis report represents a synthesis of seven ”environmental compensation1” research projects funded by the Swedish Environmental Protection Agency and Swedish Agency for Marine and Water Management between 2018 and 2021. This synthesis has been built upon the final reports of each individual research project, as well as comments provided by the two funding agencies that emphasized specific aspects
Emotion regulation (ER) is implicated in a range of psychopathologies and behavioral problems that are prevalent or have their initial onset in adolescence. In this study, we aim to evaluate the psychometric properties (factor structure, internal consistency, and construct validity) of the Adolescents’ Emotion Regulation Strategies Questionnaire–Extended (AERSQ-E), a modified and extended version
Images are created not in a vacuum but in hidden yet potent, contending political forces. The missionary endeavour of the nineteenth century was not exempt from this reality. Images became integral to missionary publications and shaped the metropolitan imagination regarding the colonised people, their religion, gods, and rituals. Displaying the colonies and their people was of utmost importance as
During the years of their colonial subjugation, the colonial subjects had gotten into themselves the seed of “inferiority complex”, which in turn made them feel that white skins are superior. This psychological trauma was so intense that they tend to run away from their own individuality by imbibing the traits of their own masters, inorder to be equal or to be accepted by the white community. This
This book offers an analysis of archaeological imagery based on new materialist approaches. Reassessing the representational paradigm of archaeological image analysis, it argues for the importance of ontology, redefining images as material processes or events that draw together differing aspects of the world. The book is divided into three sections: 'Emergent images', which focuses on practices of
Over the last few decades, a critical revision of prior scholarship concerning Roman domestic space has led to the reappraisal of the traditional account of the atrium suggesting a possibility for this space to be ‘unroofed’. Accordingly, scholars have proposed to look for a convergence of impulses previously cultivated in isolation combining new theoretical frameworks, and a careful examination o
In recent decades, studies of Roman domestic space have proliferated. The result is a rich but impenetrable picture, with scholars often favoring the use of ancient sources on one hand and finds from excavated houses or material remains on the other. Studies have emphasized how light can be approached to investigate space and its social meaning. At the same time, in the field of digital technologi
Interpreting the social complexity of the Roman house requires a careful evaluation of existing evidence. With this in mind, recent work in the field has proposed a variety of different approaches, focusing each time on a specific type of source (architecture and décor, ancient texts, material evidence from excavated houses), each in turn recursively deemed more adequate for the purpose or more fr
