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Breast cancer is the most commonly diagnosed cancer among women in Sweden, as well as worldwide. In Sweden, 8,288 women were diagnosed with invasive breast cancer in 2019, out of whom approximately 1.5% were younger than 35 years of age. Although breast cancer is relatively uncommon in young women, they tend to be diagnosed with more aggressive tumors at a more advanced stage, and have a poorer pr
BACKGROUND: Ex vivo lung perfusion (EVLP) is used to evaluate and recondition extended criteria donor lungs for transplantation. Interleukin-1β (IL-1β) has been identified as a prognostic indicator of nonrecovery during EVLP. This may be an effect of inflammasome activation or cellular necrosis following donation and graft preservation. Delineating the mechanism of IL-1β release is required. METHO
PURPOSE: Burkitt lymphoma (BL) has unique biology and clinical course but lacks a standardized prognostic model. We developed and validated a novel prognostic index specific for BL to aid risk stratification, interpretation of clinical trials, and targeted development of novel treatment approaches. METHODS: We derived the BL International Prognostic Index (BL-IPI) from a real-world data set of adu
COVID-19 pandemic has showed the world more than ever the relevance of green and public spaces for the fulfilment of human rights in urban settings. The role they will play in post-pandemic socio-environmental recovery will be central, particularly in highly densified cities of the Global South.
The armed conflict between 1986 and 2007 in Northern Uganda had profound impacts on human rights and on the degradation of the natural environment. Unfortunately, peacetime did not revert this. On the contrary, the consolidation of extractive supply chains is bringing environmental deterioration to another scale while social conflicts are emerging among ethnic groups, local communities, families,
Introduction Although various lipid and non-lipid analytes measured by nuclear magnetic resonance (NMR) spectroscopy have been associated with type 2 diabetes, a structured comparison of the ability of NMR-derived biomarkers and standard lipids to predict individual diabetes risk has not been undertaken in larger studies nor among individuals at high risk of diabetes. Research design and methods C
BACKGROUND: Contact allergen prevalences often change. Continual surveillance is necessary to detect trends in sensitization rates and emerging allergens.OBJECTIVE: To identify the prevalence of, and trends in, the positive reactions to each allergen in the baseline series during a 12-year period in Thailand.METHODS: The medical records of 2803 patients who underwent patch testing at the Contact D
BACKGROUND: Methylchloroisothiazolinone, in combination with methylisothiazolinone (MCI/MI), and MI alone are common preservatives. The incidences of MCI/MI and MI-alone contact allergies have risen markedly worldwide, leading to changes in their use in products.OBJECTIVES: The aim of the study was to determine the incidences of positive patch test reactions and factors associated with MCI and/or
BACKGROUND: Hair cosmetics such as hair dyes, bleaching, waving, and cleansing products are composed of numerous chemical ingredients. Allergic reactions to these contact allergens, other than p-phenylenediamine, are rarely reported.OBJECTIVES: To study the incidence of patch test reactions to hair cosmetic allergens and identify the factors associated with hair cosmetic allergy in Thailand.METHOD
Water damages in buildings in the Nordic countries results in costs amounting to several billion Euros each year as well as a great deal of unpleasantness. The vast majority of the water damages cost in Sweden is caused by leaks from buildings services in the form of piping such as tap water, sewage, drainage and heating, as well as through insufficiently waterproof layers in wet rooms. The econom
This study has analysed which options would be appropriate to use as additional requirements to the main requirement of primary energy number in the new Swedish building regulations. The starting point is to ensure that buildings are built with good qualitative properties in terms of the building envelope so that low energy use can be maintained throughout the life of the building despite changes
Here we report on the experimental results and advanced self-consistent real device simulations revealing a fundamental insight into the non-linear optical response of n+-i-n+ InP nanowire array photoconductors to selective 980 nm excitation of 20 axially embedded InAsP quantum discs in each nanowire. The optical characteristics are interpreted in terms of a photogating mechanism that results from
Mitogens trigger cell division in animals. In plants, cytokinins, a group of phytohormones derived from adenine, stimulate cell proliferation. Cytokinin signaling is initiated by membrane-associated histidine kinase receptors and transduced through a phosphorelay system. We show that in the Arabidopsis shoot apical meristem (SAM), cytokinin regulates cell division by promoting nuclear shuttling of
Several extensions of the Standard Model predict the production of dark matter particles at the LHC. An uncharted signature of dark matter particles produced in association with VV=W±Wa"or ZZ pairs from a decay of a dark Higgs boson s is searched for using 139 fb-1 of pp collisions recorded by the ATLAS detector at a center-of-mass energy of 13 TeV. The s→V(qq)V(qq) decays are reconstructed with a
Concussion is a frequent injury in many sports and is also common in para athletes. However, there is a paucity of concussion research related to para sport, and prior International Concussion in Sport (CIS) consensus papers have not substantively addressed this population. To remedy this and to improve concussion care provided to para athletes, the concussion in para sport (CIPS) multidisciplinar
Through the optimization of the perovskite precursor composition and interfaces to selective contacts, we achieved a p-i-n-type perovskite solar cell (PSC) with a 22.3% power conversion efficiency (PCE). This is a new performance record for a PSC with an absorber bandgap of 1.63 eV. We demonstrate that the high device performance originates from a synergy between (1) an improved perovskite absorbe
