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HflX is a ubiquitous bacterial GTPase that splits and recycles stressed ribosomes. In addition to HflX, Listeria monocytogenes contains a second HflX homolog, HflXr. Unlike HflX, HflXr confers resistance to macrolide and lincosamide antibiotics by an experimentally unexplored mechanism. Here, we have determined cryo-EM structures of L. monocytogenes HflXr-50S and HflX-50S complexes as well as L. m
The far right is notoriously effective in its use of digital media to mobilize people and to build a sense of collective identity around oppositional cultures. Yet, while research has begun to explore far-right groups’ social media hyperlinking activities, relatively little is known about the purposes and communicative functions of this form of communication. By combining social network analysis a
Recent decades have seen a blurring of the line between extremist movements and mainstream politics, driven by rising sectarian polarization. This development has been linked to digital media, with suggestions that so-called echo chambers may drive political radicalization. To understand the social processes taking place inside such digital spaces, this article draws on Randall Collins and the Dur
ObjectivesDiet has received attention as a factor possibly contributing to the development of Rheumatoid arthritis (RA). Several dietary exposures have been examined in various populations using different diet assessment methods. The aim of this study was to systematically assess the literature on the relation between dietary patterns, different food and food groups, macronutrients, non-alcoholic
This study uses a novel approach to identifying local contextual conditions conducive, alone or in combination to far-right political violence. The studied case is asylum housing attacks occurring in Sweden 2015-16. Using a fuzzy-set qualitative comparative analysis of eighty-six Swedish municipalities, forty-two of which have experienced arson attacks against refugee housing facilities, we operat
Objective. To explore long-term cardiovascular outcomes and mortality in patients after a first myocardial infarction (MI) compared with matched controls in a contemporary setting. Methods. During 2010–2014 the Swedish study PAROKRANK recruited 805 patients <75 years with a first MI and 805 age-, gender-, and area-matched controls. All study participants were followed until 31 December 2018, throu
Despite systematic screening and improved treatment strategies, the prognosis remains worse in patients with connective tissue disease-associated pulmonary arterial hypertension (CTD-PAH) compared to patients with idiopathic/hereditary pulmonary arterial hypertension (IPAH). We aimed to investigate differences in clinical characteristics, outcome and performance of the European Society of Cardiolo
Aims: Temporal changes in patient selection and major technological developments have occurred in the field of left ventricular assist devices (LVADs), yet analyses depicting this trend are lacking for Europe. We describe the advances of European LVAD programmes from the PCHF-VAD registry across device implantation eras. Methods and results: Of 583 patients from 13 European centres in the registry
This thesis deals with the modeling of structured signals under different sparsity constraints. Many phenomena exhibit an inherent structure that may be exploited when setting up models, examples include audio waves, radar, sonar, and image objects. These structures allow us to model, identify, and classify the processes, enabling parameter estimation for, e.g., identification, localisation, and t
Chemically enhanced primary treatment (CEPT) followed by microsieving and direct membrane filtration (DMF) as ultrafiltration, was evaluated on pilot scale at a municipal wastewater treatment plant. In addition, a granular activated carbon (GAC) filter downstream of DMF was evaluated for the removal of organic micropollutants. Up to 80% of the total organic carbon (TOC) and 96% of the total phosph
This collaborative statement from the International Society for Holter and Noninvasive Electrocardiology/Heart Rhythm Society/European Heart Rhythm Association/Asia Pacific Heart Rhythm Society describes the current status of mobile health (“mHealth”) technologies in arrhythmia management. The range of digital medical tools and heart rhythm disorders that they may be applied to and clinical decisi
Kinesthetic teaching allows human operators to reprogram part of a robot’s trajectory by manually guiding the robot. To allow kinesthetic teaching, and also to avoid any harm to both the robot and its environment, Cartesian impedance control is here used for trajectory following. In this paper, we present an online method to modify the compliant behavior of a robot toward its environment, so that
Radiogenic isotopes provide an important means towards elucidating Archean crustal evolution. The global Hf and Nd isotope record of Archean crustal fragments has been instrumental to unveiling the history of ancient crustal growth and differentiation. The Rb-Sr system could provide valuable complementary constraints in this regard, as this system is particularly sensitive to magmatic fractionatio
The aim of this study is to understand the response of public organizations and frontline public servants to the organizational hybridity that occurs when public organizations adopt market-inspired elements. To reach the aim I examine public sector customer orientation and how public organizations, as well as their employees, manage customer orientation, and the demands that the concept presents,
