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Predicting Grade group 2 or higher cancer at prostate biopsy by 4Kscore in blood and uCaP microRNA model in urine

Elevated prostate-specific antigen (PSA) levels often lead to unnecessary and possibly harmful transrectal ultrasound guided biopsy, e.g. when the biopsy is negative or contains only low-grade insignificant cancer, unlikely to become symptomatic in the man’s normal lifespan. A model based on four-kallikrein markers in blood (commercialized as 4Kscore) predicts risk of Grade group 2 or higher prost

Testing the migration syndrome : Comparative fecundity of migratory and non-migratory nymphaline butterflies

Empirical studies have shown a positive relationship between migration and fecundity, suggesting a ‘migration syndrome’ that also includes delayed reproduction and an extended reproductive lifespan. At the same time, life history theory predicts that the cost of migration should result in lower fecundity because both traits draw from a common resource. We test whether migration is associated with

Understanding Person-Environment Relationships as Criteria to Support the Operationalization of Universal Designing

To reach a broader understanding of person-environment relationships as building blocks for universal design in research and practice, this paper combine and discuss three types of interaction between individuals and environments - instrumental, non-instrumental, and non-physical - and five constituent concepts, i.e. accessibility, usability, aesthetic experience, the experience of meaning and emo

State of science in carbon budget assessments for temperate forests and grasslands

With the abundance of observations and advancement in modeling, temperate regions allow for a comprehensive comparison of the data-driven and process-based methods of carbon budget estimation. This chapter presents a review of the latest methodologies for carbon budget and component flux estimation, and the key components in the temperate carbon budget, such as forest regrowth, and summarizes unce

Biokinetics and dosimetry of 18F-PSMA-1007 in patients with prostate cancer

Purpose: Positron emission tomography-computed tomography (PET-CT) using prostate-specific membrane antigen (PSMA) ligands is a method for imaging prostate cancer. A recent tracer, 18F-PSMA-1007, offers advantages concerning production and biokinetics compared to the standard tracer (68Ga-PSMA-11). Until now, radiation dosimetry data for this ligand was limited to the material of three healthy vol

Cellular Localization for Autonomous Driving: A Function Pull Approach to Safety-Critical Wireless Localization

Cellular localization has received marked attention in academia and in industry, as indicated by a rapidly expanding volume of literature specific to vehicular environments. Impressive results have been shown for a number of problems as measured by metrics such as accuracy and latency. This article identifies five important requirements for cellular localization for safety-critical systems with a