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On the use of sequential Monte Carlo methods for approximating smoothing functionals, with application to fixed parameter estimation

Sequential Monte Carlo (SMC) methods have demonstrated a strong potential for inference on the state variables in Bayesian dynamic models. In this context, it is also often needed to calibrate model parameters. To do so, we consider block maximum likelihood estimation based either on EM (Expectation-Maximization) or gradient methods. In this approach, the key ingredient is the computation of smoot

Pharmacokinetic studies on 5-aminolevulinic acid-induced protoporphyrin IX accumulation in tumours and normal tissues

Laser-induced fluorescence (LIF) for in vivo point monitoring and fluorescence microscopy incorporating a CCD camera were used to study the fluorescence distribution of 5-aminolevulinic acid (ALA)-induced protoporphyrin IX (PpIX) in tumours. Fluorescence in a chemically induced adenocarcinoma in the liver of rats and in an aggressive basal cell carcinoma in a patient were studied after intravenous

Cardiovascular Risk, Cardiac Function, Physical Activity, and Quality of Life with and without Long-Term Growth Hormone Therapy in Adult Survivors of Childhood Acute Lymphoblastic Leukemia.

Context: Long-term data are missing in GH-treated acute lymphoblastic leukemia (ALL) patients. GH therapy may result in poorer outcome regarding cardiovascular (CV) and particularly cardiac effects than in patients with hypothalamic-pituitary disease. Objective: Our objective was to evaluate GH therapy on CV risk, cardiac function, physical activity, and quality of life in ALL patients treated wit

Social relationships and health as predictors of life satisfaction in advanced old age: results from a Swedish longitudinal study

This longitudinal study examines the relationship between family and friend social support, health, and life satisfaction for a single cohort of eighty-year-old persons living in Lund, Sweden. Results indicate that participants who remained in the study are healthier and score higher on life satisfaction when compared with those who either drop-out or die prior to age eighty-three. Even though wel

Radiative lifetime measurements in TmIII with time-resolved laser spectroscopy and comparisons with HFR calculations

Natural radiative lifetimes of eight levels in Tm m were measured with the time-resolved laser-induced fluorescence (LIF) technique. Free doubly ionized thulium ions were obtained in a laser-produced plasma. Three even-parity levels were excited from the ground state with one-photon excitation, using a laser system generating pulses of 1 ns duration. Five odd-parity levels were excited from the gr

Elen är fri. Energianvändning ur ett kulturanalytiskt perspektiv

Studien utgör en del i ett tvärvetenskapligt forskningsprogram, ¯Effekthushållning i byggnader¯, genomfört vid Lunds Universitet. Den här studien har fokuserat energianvändning i bostäder ur ett kulturanalytiskt perspektiv. Detta har inneburit ett åskådliggörande av möten mellan bransch och brukare på den omreglerade elmarknaden. Här har vardagslivet varit en metodisk och analytisk utgångspunkt fö

Immunological systems biology: gene expression analysis of B-cell development in Ramos B-cells.

B-cell development into antibody producing cells is a complex process that relies on the tightly controlled production of hundreds of genes and proteins. A B-cell is activated through the B-cell receptor (BCR) and this activation is modified by different co-stimulatory or inhibitory co-receptors. The concerted action of signals from BCR and from co-receptors decides the fate of the B-cells. The ma

Rehabilitation Engineering and Design Research - Theory and Method

All scientific research requires problem definition and discipline, as well as concept and method formation. However, from a human point of view the most important problems are probably those found in areas where it may be difficult to provide such ideal research conditions. Rehabilitation engineering and design research is one such field. Nonetheless, we believe that these theory and method forma

Nonequilibrium Green’s function theory for transport and gain properties of quantum cascade structures

The transport and gain properties of quantum cascade (QC) structures are investigated using a nonequilibrium Green's function (NGF) theory which includes quantum effects beyond a Boltzmann transport description. In the NGF theory, we include interface roughness, impurity, and electron-phonon scattering processes within a self-consistent Born approximation, and electron-electron scattering in a mea