Search results

We shall explore genetic function by a combination of genetic and functional assays. First, via expression profiling, we intend to determine which genes for mitochondrial proteins are altered in pancreatic β-cells, liver, skeletal muscle, and adipose tissue. This will be performed in material from i) humans with or without the disease, ii) in genetically or pharmacologically manipulated animals an

https://www.ludc.lu.se/welcome-lund-university-diabetes-centre/project-areas/mitocondria - 2025-11-29

To accomplish these goals we will: A) establish the stimulus-secretion coupling in human pancreatic islets from non-diabetic organ donors to obtain proof of concepts derived from rodent studies; these data will also establish the gold standard for efforts to differentiate embryonic stem cells into mature islet cells. B) Combine islet studies with genetic and metabolic studies in humanA) Our knowle

https://www.ludc.lu.se/welcome-lund-university-diabetes-centre/project-areas/islets - 2025-11-29

How do we get people from different cultures, industries and worlds to sit down and talk to each other? First, they need to be brought together, and this alone requires the right person for the job. Meet Paola Hjelt, member of Lund University Diabetes Centre’s Innovation Board, who talks about on how to accomplish a change of mindset. She grew up in Brussels, Belgium, has one degree from the Stock

https://www.ludc.lu.se/meetings-prerequisite-change - 2025-11-29

PI: Nils Wierup The emergence of morbidly obese patients has prompted novel approaches to achieve weight reduction. Given that energy reduction by dieting is largely unsuccessful in this paitent group, surgical procedures have instead been developed to dramatically restrict food intake. Indeed, over the course of months patients may loose up to 50% in body weight. In addition, the majority of pati

https://www.ludc.lu.se/about-us/action-groups/metabolic-surgery-action-group - 2025-11-29

PI: Albert Salehi The antiology of metabolic syndrome and type 2 diabetes is complex and involves the interaction between both genetic and environmental factors (also including nutritional and metabolic signals). It has been known for at long time that dysfunction fo pancreatic islets cell (α-, β- and δ-cell) is a critical factor in the development and progression of these diseases.One of the larg

https://www.ludc.lu.se/about-us/action-groups/gpcr-action-group - 2025-11-29

Glucolipotoxicity:We will identify defects in the regulation of adipose tissue lipid metabolism associated with obesity and diabetes using models with altered expression of hormone sensitive lipase (HSL), the rate-limiting step in lipolysis 39 and phosphodiesterase3B (PDE3B) 40-42, a key enzyme controlling insulin action HSL activity. Altered profiles of lipid derived second messengers and alterat

https://www.ludc.lu.se/welcome-lund-university-diabetes-centre/project-areas/target-tissues - 2025-11-29

New drug targetsWe have in the different sections tested a number of pathways as putative new drug targets including exploring the role of TXNIP for the development of glucotoxicity in β-cells, muscle and kidney and the role of glucokinase in the β-cells. We have also explored the role of Ncf1 in thymus mediated control of tolerance. Potentially, all studied pathways can include regulatory steps w

https://www.ludc.lu.se/welcome-lund-university-diabetes-centre/project-areas/therapy - 2025-11-29

My research embraces a broad range of research projects for the development of person-centered radiography in cancer screening and for the standardization of diagnostic methods in medical imaging. The projects focus on the individual's perspective in health care and covers areas as follows: 1) evaluation of patient-reported outcomes in cancer screening, 2) development and validation of person-cent

https://www.luci.lu.se/en/person-centered-radiography-cancer-screening-and-development-radiographic-examinations-medical - 2025-11-29

In a pioneering project, we are using pressure sensors to investigate and improve breast imaging. Mechanical imaging can be described as using pressure sensors to investigate the surface pressure of a compressed object. From the surface pressure, or stress, the local stiffness can be estimated. This is both useful and convenient in breast imaging: the breast is compressed during mammography, and b

https://www.luci.lu.se/en/breast-mechanical-imaging - 2025-11-29

With a unique database of images we are investigating the use of artificial intelligence in breast imaging. Progress in Artificial Intelligence – AI – is rapid in many medical fields. In breast imaging, AI has mainly been used to improve CAD – computer assisted detection. Traditional CAD indicates suspicious areas on the mammogram, but is ineffective in screening as excessive marks distract reader

https://www.luci.lu.se/en/artificial-intelligence-breast-imaging - 2025-11-29

My name is Ann-Sofi Sjöqvist, and I am a registered radiographer, MSc and doctoral student. I work in Malmö at the Department of Medical Imaging and Physiology Skåne university Hospital and have been working with MRI since 2004. Between 2007 and 2011 I worked at Hvidovre Hospital in Denmark at the DRCMR department and there is where my research interest awoke. In Denmark I enrolled for a master pr

https://www.luci.lu.se/en/about-us/experiences-women-inherited-risk-breast-cancer-undergoing-yearly-surveillance-mri-breast-sweden - 2025-11-29

Women with high breast density have an increased risk of breast cancer. At the same time is mammography less effective in finding an existing cancer in these dense breasts. Mammography creates a 2D image of a 3D structure which has the potential to result in superimposing tissue, hiding lesions of interest. Tomosynthesis is an upcoming method for 3D screening with the potential of improving the ef

https://www.luci.lu.se/en/individualized-breast-cancer-screening-tomosynthesis-depending-breast-density - 2025-11-29

Increased breast density is an established strong risk factor for breast cancer. However, its prognostic potential is elusive. Some studies have reported worse outcome for women with dense breasts, while most have not found an association. Mammographic tumour appearances are related to tumour characteristics. In my first project we saw that spiculated tumour appearance is associated with favourabl

https://www.luci.lu.se/en/does-mammographic-density-and-mammographic-tumour-appearance-impact-survival-breast-cancer - 2025-11-29

My PhD project is a result of an international collaboration between Lund University and Siemens Healthineers. The focus with the project is investigating the possible benefits of synthetic mammography (SM) as supplemental imaging technique to digital breast tomosynthesis (DBT) in a screening setting. The goal of using SM is to add additional information to the radiologist and help improve decisio

https://www.luci.lu.se/en/breast-mechanical-imaging/possible-benefits-synthetic-mammography - 2025-11-29

We investigate the possibilities to use artificial intelligence (AI) to improve breast cancer screening with either standard digital mammography (DM) or digital breast tomosynthesis (DBT), which can be seen as a kind of 3D mammography. Today DM is used for breast cancer screening. In order to detect as many cancers as possible, each image is read by two specialised breast radiologists. DBT can fin

https://www.luci.lu.se/en/artificial-intelligence-breast-imaging/can-breast-cancer-screening-be-improved-artificial-intelligence - 2025-11-29

Project description: DBTMI is motivated by a challenge of underdiagnosis and false positives (FPs) in breast cancer healthcare. Mammography screening reduces mortality by early cancer detection. It is limited by FPs and unnecessary biopsies, with related complications, anxiety, and burden on the healthcare system. MI maps local pressure on the breast compressed during x-ray exam. Increased pressur

https://www.luci.lu.se/en/simultaneous-digital-breast-tomosynthesis-dbt-and-mechanical-imaging-mi-dbtmi - 2025-11-29

Project description: Virtual Clinical Trials (VCTs) in medical imaging have been used to design, evaluate, and optimize imaging systems; to prototype clinical trials; and to assist with regulatory approval. VCTs are used as a rapid and cost-effective alternative to conventional clinical trials, allowing researchers to answer fundamental questions using in-silico simulations. My team of researchers

https://www.luci.lu.se/en/virtual-clinical-trials-vcts-medical-imaging - 2025-11-29

Project description: Women with a high risk for breast cancer are defined as having (i) a life-time risk of a new primary breast cancer >20%, based on the prevalence of hereditary gene mutation (BRCA1, BRCA2 etc.), (ii) a positive family history, or (iii) previously diagnosed breast cancer before 50 years of age. High-risk patients have a higher incidence of breast cancer, with lesions appearing e

https://www.luci.lu.se/en/evaluation-high-risk-screening-breast-cancer-south-swedish-health-care-region - 2025-11-29

The purpose of this project is to develop and evaluate three non-invasive examination methods for the diagnosis of breast tumors, namely photoacoustics, diffuse reflectance spectroscopy and ultrasound-based tissue characteristics. It is our hope that the methods will be used for primary diagnostic of breast cancer, planning of breast cancer surgery but also to evaluate the given preoperative cance

https://www.luci.lu.se/en/spectroscopy-and-photoacoustics-noninvasive-diagnosis-breast-cancer-optical-methods - 2025-11-29

Technology development pushes us to find new ways of working, also in breast screening. Breast screening has been organized in the same manner since the 1980's, apart from the switch from analogue to digital mammography (DM) in late 1990's, which was a huge practical leap forward. In Sweden and many northern European countries double-reading is practiced, where two breast radiologists independentl

https://www.luci.lu.se/en/building-malmo-breast-imaging-database-evaluation-artificial-intelligence - 2025-11-29