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The metabolism in vivo in the rat of 125I-prothrombin-chylomicron complexes was compared to that of free 125I-prothrombin injected in saline or together with chyle chylomicrons. The group that obtained 125I-prothrombin-chylomicron complexes exhibited a faster initial decrease of plasma 125I-prothrombin, a higher radioactivity in the liver and more trichloroacetic acid soluble 125I in plasma than i
The ability of chyle chylomicrons to bind prothrombin has been studied. Rat chyle chylomicrons were incubated with human 125I-prothrombin and binding was examined by separating the chylomicrons from free 125-I-prothrombin by density-gradient ultracentrifugation, and by gel filtration on Sepharose CL-2B. A significant binding of prothrombin to chyle chylomicrons occurred. The complex formation was
The effects of chylomicron-prothrombin complexes on platelet activation, including platelet aggregation, serotonin release, arachidonic acid release and increases of platelet cytosolic [Ca2+]i were examined. Furthermore the role of platelet factor Xa on the conversion of chylomicron bound prothrombin to thrombin was studied by using a synthetic inhibitor of factor Xa, TenStop. The chylomicron-protThe effects of chylomicron-prothrombin complexes on platelet activation, including platelet aggregation, serotonin release, arachidonic acid release and increases of platelet cytosolic [Ca2+]i were examined. Furthermore the role of platelet factor Xa on the conversion of chylomicron bound prothrombin to thrombin was studied by using a synthetic inhibitor of factor Xa, TenStop. The chylomicron-prot
The effects on platelet aggregation of native rat chyle chylomicrons, chylomicron remnants, and chylomicrons that had been preincubated with rat or human EDTA-plasma, serum, whole blood, or pure human prothrombin were examined. The native chyle chylomicrons did not induce platelet aggregation but decreased ADP- and thrombin-induced platelet aggregation and [14C]serotonin release. Chylomicron remna
This work is an experimental study covering minimum quantity lubrication (MQL) in sheet metal forming. Two different lubricants have been studied. Nanosized graphite platelets (GnP) has been tested as additives to the base oils in order to improve the lubricant performance. The experiments have been performed utilizing a laboratory tribotester based on strip drawing. Friction measurements have bee
The current study demonstrates through experiment the effect of solid lubricant assisted minimum quantity lubrication (MQL) on the machining performance when turning Alloy 718 with cemented carbide tools. A powder of nanosized (~30 nm) graphite nanoplatelets (GnP) was dispersed (0.2% vol.) in a vegetable oil-based lubricant “ECOLUBRIC E200L” and used in MQL-assisted machining. The effect of cuttin
Fiber reinforcement polymer (FRP) is a hard-to-treat material used in different areas of up-to-date machine building. It has excellent mechanical properties making the material unique in different engineering solutions such as aircraft, aerospace and boatbuilding. The optimization of holemaking operations in FRP is the main aim of the current investigation. This paper presents an approach of definFiber reinforcement polymer (FRP) is a hard-to-treat material used in different areas of up-to-date machine building. It has excellent mechanical properties making the material unique in different engineering solutions such as aircraft, aerospace and boatbuilding. The optimization of holemaking operations in FRP is the main aim of the current investigation. This paper presents an approach of defin
Key Performance Indicators (KPIs) are not only essential during manufacturing operations. Also during the development phases of product and manufacturing system, where future performance of the operational order-to-delivery-process is set, KPIs are important to consider. This paper introduces "enabling indicators" that can be analyzed or assessed in early phases of product and manufacturing develo
EPA (entrustable professional activities) avser aktiviteter som ingår i en läkares dagliga arbete och som läkaren ska klara med en definierad grad av självständighet första dagen som legitimerad läkare.En modell för att träna och bedöma sådana aktiviteter kan säkerställa att studenter klarar av det faktiska arbete som ska utföras första dagen efter legitimation, och den tydliggör också progressionEntrustable Professional Activities (EPAs) define observable key tasks that a doctor should be able to do independently after having completed a certain level of education. Progression is facilitated by frequent assessments of the defined activities, with increased degree of independence. The observations should be supported by constructive feed-forward. EPA is currently used in several countries
