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Collected Works of Shimshon Rosenbaum : Volume 2: Selected Articles and Speeches on International Law, Zionism, Self-Determination, Autonomy, and Statehood of the Jewish Nation

Denna serie (ISBN 978-91-986003-0-8) innehåller den litauenjudiske statsmannen, folkrättsjuristen och sionistiske diplomaten Shimshon Rosenbaums (1859–1934) samlade verk på originalens språk med fullständiga översättningar till engelskan. I band 2 samlas hans artiklar och tal om folkrätt, sionism samt den judiska nationens självbestämmande, autonomi och statlighet.

Urban Nature - Connecting Cities, Sustainability and Innovation : Course Guide

How can we work with nature to design and build our cities? This course explores urban nature and nature-based solutions in cities in Europe and around the world. We connect together the key themes of cities, nature, sustainability and innovation. We discuss how to assess what nature-based solutions can achieve in cities. We examine how innovation is taking place in cities in relation to nature. A

Dizziness and localized pain are often concurrent in patients with balance or psychological disorders

Background and aims Symptoms of dizziness and pain are both common complaints and the two symptoms often seem to coincide. When symptoms appear concomitant for sustained periods of time the symptoms might maintain and even exacerbate each other, sometimes leading to psychological distress. In order to evaluate such comorbidity we studied patients referred to a vestibular unit and to a psychiatric

The human methyltransferase ZCCHC4 catalyses N6-methyladenosine modification of 28S ribosomal RNA

RNA methylations are essential both for RNA structure and function, and are introduced by a number of distinct methyltransferases (MTases). In recent years, N6-methyladenosine (m6A) modification of eukaryotic mRNA has been subject to intense studies, and it has been demonstrated that m6A is a reversible modification that regulates several aspects of mRNA function. However, m6A is also found in oth

The dual methyltransferase METTL13 targets N terminus and Lys55 of eEF1A and modulates codon-specific translation rates

Eukaryotic elongation factor 1 alpha (eEF1A) delivers aminoacyl-tRNA to the ribosome and thereby plays a key role in protein synthesis. Human eEF1A is subject to extensive post-translational methylation, but several of the responsible enzymes remain unknown. Using a wide range of experimental approaches, we here show that human methyltransferase (MTase)-like protein 13 (METTL13) contains two disti

Regulation of eukaryotic elongation factor 1 alpha (eEF1A) by dynamic lysine methylation

Lysine methylation is a frequent post-translational protein modification, which has been intensively studied in the case of histone proteins. Lysine methylations are also found on many non-histone proteins, and one prominent example is eukaryotic elongation factor 1 alpha (eEF1A). Besides its essential role in the protein synthesis machinery, a number of non-canonical functions have also been desc

Identification of FAM173B as a protein methyltransferase promoting chronic pain

Chronic pain is a debilitating problem, and insights in the neurobiology of chronic pain are needed for the development of novel pain therapies. A genome-wide association study implicated the 5p15.2 region in chronic widespread pain. This region includes the coding region for FAM173B, a functionally uncharacterized protein. We demonstrate here that FAM173B is a mitochondrial lysine methyltransfera