Background: Effectiveness of biologics has neither been established in patients with high oral corticosteroid exposure (HOCS) nor been compared with effectiveness of continuing with HOCS alone. Objective: To examine the effectiveness of initiating biologics in a large, real-world cohort of adult patients with severe asthma and HOCS. Methods: This was a propensity score–matched, prospective cohort

Context. The population of strongly irradiated Jupiter-sized planets has no equivalent in the Solar System. It is characterised by strongly bloated atmospheres and large atmospheric scale heights. Recent space-based observations of SO2 photochemistry have demonstrated the knowledge that can be gained about Earth's uniqueness from detailed atmospheric studies of these unusual planets. Aims. Here we

Tomographic X-ray imaging techniques offer novel opportunities for studying membranes and membrane processes in 3D on a spatial resolution not seen before. Traditional 2D imaging techniques used to characterise membranes have limitations that can be overcome by tomographic X-ray imaging. Tomographic X-ray imaging can provide information in 2D/3D or 4D (3D plus time) on membranes, membrane modules,

A generic search for resonances is performed with events containing a Z boson with transverse momentum greater than 100 GeV, decaying into e + e − or μ + μ −. The analysed data collected with the ATLAS detector in proton-proton collisions at a centre-of-mass energy of 13 TeV at the Large Hadron Collider correspond to an integrated luminosity of 139 fb −1. Two invariant mass distributions are exami

The production of K∗(892)0and φ(1020)resonances has been measured in p-Pb collisions at sNN = 8.16 TeV using the ALICE detector. Resonances are reconstructed via their hadronic decay channels in the rapidity interval -0.5 < y < 0 and the transverse momentum spectra are measured for various multiplicity classes up to pT = 20 GeV/c for K∗(892)0and pT = 16 GeV/c for φ(1020). The pT-integrated yields

Two-particle transverse momentum differential correlators, recently measured in Pb-Pb collisions at energies available at the CERN Large Hadron Collider (LHC), provide an additional tool to gain insights into particle production mechanisms and infer transport properties, such as the ratio of shear viscosity to entropy density, of the medium created in Pb-Pb collisions. The longitudinal long-range

The electroweak production of Z(νν¯) γ in association with two jets is studied in a regime with a photon of high transverse momentum above 150 GeV using proton–proton collisions at a centre-of-mass energy of 13 TeV at the Large Hadron Collider. The analysis uses a data sample with an integrated luminosity of 139 fb−1 collected by the ATLAS detector during the 2015–2018 LHC data-taking period. This

Contemporary markets grapple with pressing challenges to secure socially and economically outcomes. Against this backdrop, market failures, notably those accentuated by sustainability and income inequality issues, have risen to prominence in competition law discourse, both doctrinally and in the realm of policymaking. This dynamic hints at an evolving paradigm: competition law might no longer be i

Investments in rail are usually expected to improve accessibility for individuals. The value of the additional accessibility is often measured by the impact on housing prices nearby. This paper analyses the City Tunnel in Southern Sweden, a major railway investment that resulted in two new train stations in 2010: the Triangeln and Hyllie train stations. A station may affect housing prices both dir

E-scooter sharing is a potential feeder to complement public transit for alleviating the first-and-last-mile problem. This study investigates the integration between shared e-scooters and public transit by conducting a comparative analysis in 124 European cities based on vehicle availability data. Results suggest that the integration ratios of e-scooter sharing in different cities show significant

Accurate and rapid detection of nucleic acid sequences is of utmost importance in various fields, including disease monitoring, clinical treatment, gene analysis and drug discovery. In this study, we developed a "turn-on" fluorescence biosensor that enables simple and highly efficient detection of nucleic acid biomarkers. Our approach involves the utilization of 6-carboxyfluorescein modified singl