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Life is about timing.-Carl LewisThe understanding of autoimmune type 1 diabetes is increasing, and examining etiology separate from pathogenesis has become crucial. The components to explain type 1 diabetes development have been known for some time. The strong association with HLA has been researched for nearly 50 years. Genome-wide association studies added another 60+ non-HLA genetic factors wit
Birth is a dangerous and dynamic event resulting in new life, as well as in death and loss. As distinct as the birth transition may seem, it remains essentially a process. The term ‘perinatal’ defines the phase beginning in late pregnancy when the fetus has potential to survive the delivery, and ending, roughly, seven days after birth, demarcating the period when the child gradually emerges and st
Ultrasound optical tomography (UOT) is a developing medical imaging technique with the potential to noninvasively image tissue oxygenation at depths of several centimeters in human tissue. To accurately model the UOT imaging, it is necessary the calculate the signal produced by the interaction between ultrasound and light in the scattering medium. In this paper we present a rigorous description fo
Hepatocellular carcinoma (HCC), the most common primary liver cancer, is usually diagnosed in its late state. Tyrosine kinase inhibitors such as sorafenib and regorafenib are one of the few treatment options approved for advanced HCC and only prolong the patient's life expectancy by a few months. Therefore, there is a need for novel effective treatments. Cyclophilins are intracellular proteins tha
Ganciclovir (GCV) is the first-line therapy against human cytomegalovirus (HCMV), a widespread infection that is particularly dangerous for immunodeficient individuals. Closely resembling deoxyguanosine triphosphate, the tri-phosphorylated metabolite of GCV (GCV-TP) is preferentially incorporated by the viral DNA polymerase, thereby terminating chain extension and, eventually, viral replication. H
Large attachments can dramatically affect the dynamic response of an assembled structure. In various industrial sectors, e.g., the automotive, aircraft, and shipbuilding industries, it is often necessary to predict the dynamic response of assembled structures and large attachments in early-stage engineering design. To deal with this, it is often the finite element method (FEM) that is used in the
Thanks to name statistics published by the national bureaus of statistics in Scandinavia it is possible to study the changing popularity of first names. This paper is based on statistics from the years 1998-2002 in Sweden, 1998-2000 in Finland and 1880-2000 in Norway. The rise and fall in popularity — and in some cases renaissance — of individual names are shown and analyzed.It is observed that o
A number of typical particle verbs in Swedish and English are presented and it is noted that such verbs are often forgotten in dictionaries and not given the proper treatment in grammars. One problem is the identification of these verbs, another is the fact that the verb and the particle may be separated by other words. The particle verbs must therefore be treated as discontinuous lexical items. I
Speaking involves a process of selecting words and constructions which correspond to the thoughts that one wishes to express. Different languages place different constraints on this selection process, corresponding to their typological characteristics. In this paper we show how Swedish, French and Thai preferentially express motion events differently and suggest a theoretical framework with ground
A 75 kDa protein was purified to homogeneity from granule extracts of normal human granulocytes using Sephadex G-75 chromatography, Mono-S cation exchange chromatography and chromatofocusing. The protein consisted of one chain with a molecular mass of 75 kDa, as determined by SDS/PAGE. Tryptic peptide analysis by MALDI-TOF (matrix-assisted laser-desorption ionization-time-of-flight) MS and sequenc
