Development of a 3D in vitro model to study the impact of COL4A1 expression in Pericytes on Glioblastoma migration by CRISPR/Cas9 knockout
Glioblastoma (GBM) is the most aggressive type of primary brain tumours in adults and accounts for 49.1% of the cases. Most of the cases are recorded in elderly patients, but GBM affects people of all age groups. Till date no cure has been found. Previous data has suggested that pericytes might influence tumour invasion by interacting with tumour cells by the secretion of or interaction with extra