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Aliphatic polycarbonates are prepared by ring opening polymerization of six-membered cyclic carbonates or various ratio of mixtures of six-membered cyclic carbonates using catalysts. The resulting materials are further polymerized using the extra functional group such as additional 2nd cyclic carbonate, (meth)acrylate and allylate. This process and material(s) obtained provide chlorine (e.g. phosg
At the intersection of environmental histories of war, fascism and urban parks, this article analyses the transformation of the political meaning attached to the green spaces of Madrid’s University City. Conceived in the late 1920s as a ‘university park’ inspired by North American academic campuses, the ‘Ciudad Universitaria’ was heavily damaged during the Spanish Civil War (1936–1939). The subseq
In its Advisory Opinion on the Legal Consequences arising from the Policies and Practices of Israel in the Occupied Palestinian Territory, including East Jerusalem, the International Court of Justice (ICJ) ruled not only that Israeli policies and practices in the occupied territory systematically violated international law, but also that Israel’s ‘continued presence’ (i.e. occupation) as such had
USP11 is a promising therapeutic target implicated in Alzheimer’s disease and various cancers; however, no specific inhibitors are currently available, with the only known inhibitor being mitoxantrone, which primarily targets topoisomerase II. To identify novel chemical starting points, we conducted high-throughput virtual screening using a USP11 homology model. Screening over 600,000 compounds yi
Personality traits (e.g., the Big Five) shape human behavior, decision-making, and life outcomes. Evidence from various countries suggests that these traits are not randomly distributed but follow systematic regional patterns, fueling interest in their geographical variation. We analyze N = 22,225 geo-coded personality assessments, aggregated at regional levels. Using Hot Spot analysis (Getis-Ord
To evaluate a simplified version of the Clinical Frailty Scale (SCFS) among older adults presenting to the emergency department (ED) with acute dyspnea. In this retrospective single-center cohort study, we included patients from the Acute Dyspnea Study (ADYS) cohort. Severity of illness was assessed using the Medical Emergency Triage and Treatment System (METTS). SCFS was operationalized using exi
Aims: Individuals with type 1 diabetes (T1D) are typically diagnosed at a young age and exposed to lifelong hyperglycaemia. Despite improved metabolic control, the risk of vascular complications remains challenging. However, some individuals remain free from developing major diabetic complications even after long duration, so-called “escapers”. This study investigated transcriptomic biomarkers lin
Polymer-based organic mixed ion-electron conductors (OMIECs) are a class of materials offering unique coupled dual charge transport characteristics along with appealing properties including mechanical softness, biocompatibility, tunability, volumetric capacitance, and stability. These features have been exploited in devices including organic electrochemical transistors (OECTs), neuromorphic comput
Starch microspheres are employed in medicinal products as embolization agents and drug delivery vehicles. For the encapsulation of sensitive ingredients, mild cross-linking techniques are needed, prompting interest in physical cross-linking via starch crystallization. This study investigates starch microsphere formation and crystallization kinetics in aqueous two-phase systems (ATPS) with various
Squamous cell lung carcinoma (SqCC) is the second most common histological subtype of lung cancer. Besides tumor-initiating and promoting DNA, RNA, and epigenetic alterations, aberrant cell metabolism is a hallmark of carcinogenesis. This study aimed to identify SqCC-specific key regulators that could eventually be used as new anticancer targets. Transcriptional and metabolomic data were gathered
Population-specific thresholds have not been defined for the levels of adiposity and systemic biomarkers that predict chronic health risks in people with restricted growth conditions. Here, anthropometric measures of adiposity, basal metabolic requirements, and fasted blood samples were obtained from adults with restricted growth (age 41 ± 14 years, height 1.30 ± 0.10 m, body mass 60.5 ± 18.3 kg,
Background: Many traumatic brain injury (TBI) treatment protocols, including the Lund concept, advocate the highest point of the subarachnoid space (typically the vertex) as the zero-reference point for intracranial pressure (ICP) and the level of the right atrium as the zero-reference point for mean arterial blood pressure (MAP). In 2017, at the Department of Neurosurgery in Lund, Sweden, the zer
Parasitoid wasps are major causes of mortality of many species, making host immune defences a common target of adaptive evolution, though such targets outside model species are poorly understood. In this study, we used two tests of positive selection to compare across three closely related Galerucella leaf beetles that show substantial differences in their phenotypic response to the shared parasit
Objective: To estimate the effect on healthcare resource use after introducing the World Health Organization diagnostic criteria (WHO-2013) for gestational diabetes mellitus (GDM) compared to former criteria in Sweden (SWE-GDM). Design: A cost-analysis alongside the Changing Diagnostic Criteria for Gestational Diabetes (CDC4G) randomised controlled trial. Setting: Sweden, with risk-factor based sc
