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Introduction Lynch syndrome (LS) carriers have a 20-46% lifetime risk of colorectal cancer (CRC) due to mismatch repair gene variants. Mesalamine (5-ASA, 5-aminosalicylic acid), used safely in patients with ulcerative colitis, may reduce CRC risk in LS by decreasing microsatellite instability, a key driver of LS-related cancer. This study evaluates 5-ASA's efficacy as a tolerable chemopreventive d

Background: Hemophilia B is a genetic bleeding disorder caused by a deficiency of clotting factor IX, which presents unique challenges in clinical management. Advances in therapeutic strategies for hemophilia B have significantly improved patient outcomes but have also necessitated ongoing education for healthcare professionals. This illustrated review provides an overview of the challenges and op

Two new endemic species from Bolivia, Gomphrena vallegrandensis T. Ortuño & S. Lozada-Gobilard and Gomphrena palmariensis T. Ortuño, J. Gutiérrez. & Montesinos, are described and illustrated. The former only occurs in the native open natural grassland close to the Tucuman forest (Prov. Vallegrande), and the latter is restricted to the areas with rock outcrops in the subpuna close to the in

The package ParSeq is a Python software library for Parallel execution of Sequential data analysis. It implements a general analysis framework that consists of transformation nodes - intermediate stops along the analysis propagation to visualize data, display status and provide user input - and transformations that connect the nodes. ParSeq imports data into an adjustable data model - a collection

Obesity represents a global health challenge, with a critical and urgent need for long-term, sustainable management strategies. Tirzepatide is a novel dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist. At first approved for the treatment of type 2 diabetes mellitus, tirzepatide represents one of the latest clinically approved and commercia

In this paper, we study the function spaces D(μ) by Richter (1991) and Aleman (1993), and Dμ→ by Rydhe (2019). It is known that the forward shift Mz is bounded and expansive on D(μ), and therefore D(μ) coincides with a de Branges-Rovnyak space H[B]. We show that such a B is rational if and only if μ is finitely atomic, and this happens exactly when the corresponding defect operator has finite rank

In this article, I explore the assigned role of interpreters in journalism training programmes in Vietnam, focusing on two media aid projects funded by the Swedish International Development Cooperation Agency (Sida): the Local Radio Project and the Further Training of Journalists programme. The study is based on qualitative analyses of project documentation and interviews with former trainers. A t

ImportanceThe management of complications following oral cavity squamous cell carcinoma (OCSCC) surgery can be challenging. Previous studies show conflicting results on complication risks after preoperative radiotherapy (RT), necessitating a randomized controlled trial (RCT).ObjectiveTo compare early complications during hospitalization for OCSCC surgery between patients receiving preoperative acc

In packaging, the structural integrity of paperboard under complex stresses is essential. This study examines the delamination behavior of paperboard under normal and shear loading modes, which are the base for developing mixed-mode models. Four commercial paperboard grades, sourced from fibers across three geographical regions, are investigated using Double Cantilever Beam (DCB) and Split Double

Portable optically stimulated luminescence (pOSL) analysis allows rapid relative dating of sediments that potentially can be calibrated against known OSL ages to provide an age estimate for landforms across a large area. This study uses 186 pOSL measurements and 20 OSL ages to investigate the postglacial landscape evolution inside the Younger Dryas moraines in NE Finnmark and Finnish Lapland. Aeol

This study examines how public transport passengers experience and use travel time and under what conditions they are particularly concerned about shorter travel time. Using a survey of Swedish public transport users and a follow-up focus group, we compare current patterns with a similar 2009 study. Findings indicate a slight decline in perceived value of travel time, coinciding with a marked redu

This paper reports on the educational model undertaken in two specialized summer schools in Denmark (2022) and Poland (2023) on daylighting in buildings. As a part of a European educational initiative, these schools aimed to deepen participants' understanding of the impact of daylight on building design. The programme, a collaborative effort between universities, companies, associations, professio

The circular economy constitutes a paradigm shift which has proven to be both engaging and unrealistic. While scholars and practitioners have started to advocate for a move toward the circular economy, promising a full reconfiguration of underlying practices and processes, many have become disillusioned about the lack of traction and progress. The circular economy transition has fallen between uto

This study examined Poles’ acculturation preferences profiles toward two groups: people from Ukraine and the Middle East, and their relation to perceived cultural distance. The study framework emphasizes the juxtaposition of media and political narratives surrounding migrants arriving in Poland. Representative data from 924 participants was analysed. Regarding the preference toward individuals fro

Glioblastoma (GBM), the most aggressive brain tumor in adults, is characterized by its infiltrative growth along the perivascular space. Mural cells (MCs), encompassing pericytes and smooth muscle cells, are multifunctional perivascular cells implicated in GBM progression. MCs not only facilitate vascular co-option but have also been suggested to contribute to the immunosuppressive tumor microenvi