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SH-SY5Y neuroblastoma cells are susceptible to differentiation using retinoic acid (RA) and brain-derived neurotrophic factor (BDNF), providing a model of neuronal differentiation. We compared SH-SY5Y cells proteome before and after RA/BDNF treatment using iTRAQ and phosphopeptide enrichment strategies. We identified 5587 proteins, 366 of them with differential abundance. Differentiated cells expr

Iridium(III)–pyridone complexes are commonly found to react in a cooperative and redox-neutral manner with dihydrogen and alcohols. In this work, the reactivity preferences of IrI–pyridone complexes were investigated under a variety of conditions. We have found that, in contrast to IrIII–pyridones, IrI–pyridone complexes display a strong preference to react non-cooperatively. With a new chelating

Background: Quality of life in persons with dementia is, in large part, dependent on the quality of care they receive. Investigating both subjective and objective aspects of quality of care may reveal areas for improvement regarding their care, which information may ultimately enable persons with dementia to remain living in their own homes while maintaining quality of life. The aim of this study

This study aims to reveal the effects of liquid entrainment, initial entrained fraction and tube diameter on liquid film dryout in vertical upward annular flow for flow boiling. Entrainment and deposition rates of droplets were included in mass conservation equations to estimate the local liquid film mass flux in annular flow, and the critical vapor quality at dryout conditions. Different entrainm

The Aw–Rascle–Zhang traffic model, a model of sedimentation, and other applications lead to nonlinear (Formula presented.) systems of conservation laws that are governed by a single scalar system velocity. Such systems are of the Temple class since rarefaction wave curves and Hugoniot curves coincide. Moreover, one characteristic field is genuinely nonlinear almost everywhere, and the other is lin

We have investigated strained GaAs-GaInP core-shell nanowires using transmission electron microscopy and nanofocused scanning X-ray diffraction. Nominally identical growth conditions for each sample were achieved by using nanoimprint lithography to create wafer-scale arrays of Au seed particles. However, we observe large individual differences, with neighboring nanowires showing either straight, b

Blood transfusions were dangerous and prohibited, until medicine developed modern techniques in the middle of the last century. Multi-trauma patients often present hard-to-identify multifactorial coagulopathies which should be recognized and treated before a transfusion is envisaged.

PURPOSE: To investigate assumed benefits of heparin coated cardiopulmonary bypass systems from standard non-coated CBP systems in unstable angina patients with preoperative heparinisation. STUDY DESIGN: Coagulation, complement, cytokine and Sonoclot parameters, were analyzed before total heparinisation prior to surgery, during cardiopulmonary bypass, after protamine to 48 hours after surgery. MATE

OBJECT: Subcutaneously intermittent administration of low molecular weight heparin (LMWH-Fragmin®) - (120IU/kgx2 BW) - in unstable angina was introduced clinically during the last year at our Hospital, after reports of the FRISC and FRIC studies as an alternative to continous infusion of standard heparin. In such patients with need for CABG, no data on haemostasis or anticoagulation during CBP had

OBJECT: Subcutaneously intermittent administration of low molecular weight heparin (LMWH-Fragmin®) - (120IU/kgx2 BW) -in unstable angina has been introduced clinically during the last year, after reports of the FRISC and FRIC studies as an alternative to continous infusion of standard heparin. Fragmin® could possible endanger postoperative haemostasis after CABG due to uncomplete reversal of anti-

A highly tunable linear triple quantum dot (TQD) device is realized in a single-crystalline pure-phase InAs nanowire using a local finger gate technique. The electrical measurements show that the charge stability diagram of the TQD can be represented by three kinds of current lines of different slopes and a simulation performed based on a capacitance matrix model confirms the experiment. We show t

The Biopython Project is a long-running distributed collaborative effort, supported by the Open Bioinformatics Foundation, which develops a freely available Python library for biological computation [1]. We present here details of the Biopython releases since BOSC 2016, namely Biopython 1.68, 1.69 and 1.70. Together these had 82 named contributors including 51 newcomers which reflects our policy o

Effective monitoring of flying insects is of major societal importance in view of the role of insects as indispensable pollinators, destructive disease vectors and economically devastating agricultural pests. The present paper reports on monitoring of flying agricultural pests using a continuous-wave lidar system in a rice-field location in Southern China. Using a Scheimpflug arrangement, range re

In the present study the geographical distribution, abundance and composition of Gambierdiscus was described over a 600 km longitudinal scale in the Canary Islands. Samples for cell counts, isolation and identification of Gambierdiscus were obtained from five islands (El Hierro, Tenerife, Gran Canaria, Fuerteventura and Lanzarote). Average densities of Gambierdiscus spp. between 0 and 2200 cells g

In the arid irrigated lands, understanding the impact of shallow groundwater fluctuation on soil salinization has become crucial. Thus, investigation of the possible options for maintaining the groundwater depth for improving land productivity is of great importance. In this study, under saline irrigation condition, the effects of shallow groundwater depth on water and salt dynamics in the root-zo

Stroke recovery research involves distinct biological and clinical targets compared to the study of acute stroke. Guidelines are proposed for the pre-clinical modeling of stroke recovery and for the alignment of pre-clinical studies to clinical trials in stroke recovery.

We present results from two experiments that provide the first quantification of inter-particle force networks in stiff, 3D, opaque granular materials. Force vectors between all grains were determined using a mathematical optimization technique that seeks to satisfy grain equilibrium and strain measurements. Quantities needed in the optimization - the spatial location of the inter-particle contact