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Ulcerated diabetic foot is a complex problem. Ischaemia, neuropathy and infection are the three pathological components that lead to diabetic foot complications, and they frequently occur together as an aetiologic triad. Neuropathy and ischaemia are the initiating factors, most often together as neuroischaemia, whereas infection is mostly a consequence. The role of peripheral arterial disease in d
The elderly population is increasing and with advanced age comes a higher risk for contracting diseases and excessive medicine use. Polypharmacy can lead to drug-related problems and an increased need of health care. More needs to be done to help overcome these problems. In order for new models to be successful and possible to implement in health care they have to be accepted by caregivers. The ai
Smoke from biomass combustion has been identified as a major environmental risk factor associated with adverse health effects globally. Deposition of the smoke particles in the lungs is a crucial factor for toxicological effects, but has not previously been studied experimentally. We investigated the size-dependent respiratory-tract deposition of aerosol particles from wood combustion in humans. T
Background: Treatment decisions can be difficult in men with low-risk prostate cancer (PCa). Objective: To evaluate the ability of a panel of four kallikrein markers in blood-total prostate-specific antigen (PSA), free PSA, intact PSA, and kallikrein-related peptidase 2-to distinguish between pathologically insignificant and aggressive disease on pathologic examination of radical prostatectomy (RP
Popular Abstract in Swedish Patienter med diabetes kan inte kontrollera blodsockernivåerna på grund av att de saknar insulinproducerande celler eller har icke fungerande insulinproducerande celler. Det finns olika typer av diabetes där typ 1 diabetes och typ 2 diabetes är de vanligaste formerna. Den mest framgångsrika behandling mot typ 1 diabetes är transplantation av insulinproducerande celler, Diabetes - the imbalance in glucose homeostasis is partially caused by loss or dysfunction of pancreatic insulin producing β cells or development of insulin resistance. In Type 1 diabetes β cells are destroyed in the process of an autoimmune attack, whereas in Type 2 diabetes, islets produce insufficient amounts of insulin or the insulin cannot be used adequately. So far, the most promising therap
This study is centred around different aspects of Boris Pasternak's early poetry that jeopardize semantic coherency and interpretation of his poems. Special attention is paid to metaphors, metonymies, lexical multiplicity (that is a multiplicity of relevant meanings codified in a dictionary) and obscure syntactic connections and how these aspects are combined in his poems. For this purpose the stu
Review of Claes Wahlöö, "Skånes kyrkor 1050-1949" (2014)
Background/Objectives:Considering the importance of glucose as a brain substrate, the postprandial rate of glucose delivery to the blood could be expected to affect cognitive functions. The purpose was to evaluate to what extent the rate of glucose absorption affected measures of cognitive performance in the postprandial period. In addition, cognitive performance was evaluated in relation to indiv
Two studies of testing practices for software product lines identify gaps between required techniques and existing approaches in the available literature. This Web extra offers extra details for the main article (specifically, the bibliography for the two studies described).
The prognosis for patients with lung cancer is poor with an average of 5-year overall survival rate of only 10-15 % taking all clinical stages together. The aim of this study was to elucidate the impact of the radiotherapy regimen on survival. Clinical data were collected from all the Swedish Oncology Departments for 1,287 patients with a diagnosed non-small cell lung cancer (NSCLC) subjected to c
Popular Abstract in Swedish Vi lever i en tid då klimatförändringar är en fråga som engagerar, men det krävs en djupare förståelse för hur och varför vårt klimat har förändrats för att möjliggöra realistiska förutsägelser om framtiden. Efterhand som olika metoder för att rekonstruera klimatförändringar har förfinats, och nya dateringsmetoder har utvecklats, så har förståelsen för hur klimatet föräDendrochronological analysis was applied to subfossil remains of Scots pine (Pinus sylvestris L.) buried in South Swedish peat deposits. By cross-dating Swedish bog-pine ring-width (RW) chronologies with corresponding material from North-west Germany, three Swedish RW chronologies were assigned absolute ages and yielded continuous, dated chronologies over the periods 5284-3728 BC and 2668-1108 BC.
In the honeybee Apis mellifera, the bacterial gut community is consistently colonized by eight distinct phylotypes of bacteria. Managed bee colonies are of considerable economic interest and it is therefore important to elucidate the diversity and role of this microbiota in the honeybee. In this study, we have sequenced the genomes of eleven strains of lactobacilli and eria isolated from the honey
Popular Abstract in Swedish Mäns våld mot kvinnor är ett allt mer uppmärksammat folkhälsoproblem och ett brott mot de mänskliga rättigheterna. Kvinnor utsätts för våld i alla länder oberoende av utbildningsnivå och ekonomiska tillgångar. Partnervåld av en nuvarande eller tidigare partner är den vanligaste formen av våld som kvinnor utsätts för. Våld mot kvinnor leder till både negativa mentala ochViolence against women (VAW) is an increasing public health concern. Prevalence of such violence may potentially be greater among foreign-born women due to lack of empowerment and other contributing factors. Research concerning violence against foreign-born women in Sweden is scarce. Thus, the general aim of this thesis was to obtain increased knowledge of exposure to interpersonal violence among
Background: The recommendations and the updated EAU guidelines consider early detection of PCa with the purpose of reducing PCa-related mortality and the development of advanced or metastatic disease. Objective: This paper presents the recommendations of the European Association of Urology (EAU) for early detection of prostate cancer (PCa) in men without evidence of PCa-related symptoms. Evidence
Drug treatment has been and will continue to be a successful method in modern medicine that can change the course of a disease. However, it is surprisingly seldom used in the more technically oriented orthopedic surgery. Bone healing and physiological skeletal remodeling involve a complex set of regulated signaling pathways that control the formation of new bone matrix and the resorption of damage
No abstract available
The novel human papillomavirus type 154 (HPV154) was characterized from a wart on the crena ani of a three-year-old boy. It was previously designated as the putative HPV type FADI3 by sequencing of a subgenomic FAP amplicon. We obtained the complete genome by combined methods including rolling circle amplification (RCA), genome walking through an adapted method for detection of integrated papillom
