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Bone mineral density (BMD) is the most widely used predictor of fracture risk. We performed the largest meta-analysis to date on lumbar spine and femoral neck BMD, including 17 genome-wide association studies and 32,961 individuals of European and east Asian ancestry. We tested the top BMD-associated markers for replication in 50,933 independent subjects and for association with risk of low-trauma

The Wenlock (middle Silurian) Eramosa Lagerstatte of the Bruce Peninsula, Ontario, Canada, is becoming known for its rich and diverse faunas, different preservational styles, and a combination of soft-body preservation associated with shelly body and trace fossils. Sampling for scolecodonts-the jaws of polychaete annelids-has yielded unique material. Hindenites parkheadensis new species is describ

Dekkera bruxellensis is a non-conventional Crabtree-positive yeast with a good ethanol production capability. Compared to Saccharomyces cerevisiae, its tolerance to acidic pH and its utilization of alternative carbon sources make it a promising organism for producing biofuel. In this study, we developed an auxotrophic transformation system and an expression vector, which enabled the manipulation o

Arid and semiarid Middle Eastern countries generally, and Syria in particular, face serious water shortage problems and challenges with water sustainability. Climate change, population growth, and economic development play a major role in decreasing available water resources per capita. This, in turn, has great impact on domestic, agricultural, and industrial water use. In this study, marginal and

The thesis discusses closed-loop control of the hypnotic and the analgesic components of anesthesia. The objective of the work has been to develop a system which independently controls the intravenous infusion rates of the hypnotic drug propofol and analgesic drug remifentanil. The system is designed to track a reference hypnotic depth level, while maintaining adequate analgesia. This is complicat

Continuity of care is one of the core values of family medicine and both patients and doctors consider it a vital aspect of the care of patients with chronic diseases. In 2009 a national health care reform was implemented in primary care in Sweden. This study compared the longitudinal continuity of care in primary care before and after this reform in 7121 adult diabetes patients living in Malmö. O

Background: Efficient utilization of both glucose and xylose is necessary for a competitive ethanol production from lignocellulosic materials. Although many advances have been made in the development of xylose-fermenting strains of Saccharomyces cerevisiae, the productivity remains much lower compared to glucose. Previous transcriptional analyses of recombinant xylose-fermenting strains have mainl

The main advantage of a heated-grid reactor for studying pyrolysis kinetics of solid fuel samples is that high heating rates of up to 1000 K/s can be obtained. However, one of the concerns is whether the temperature distribution over the grid material is uniform and whether the presence of a thermocouple welded to the grid causes any measurement errors. Biomass samples were placed on the heated-gr

The relation between mission, religious conversion and identity construction is the subject of my paper. On a concrete level, I discuss the Catholic mission and conversions in Scandinavia from the middle of nineteenth century to the present time. Up to the Second Vatican Council (1962-65), the Catholic Church strongly emphasised its claim to be the only true Church, and as a consequence, all non-C

The influence of electrostatic interactions on the dynamic properties of complexes containing DNA and mixtures of cationic- (DDA) and zwitterionic (DLPC) lipids are studied by means of NMR. The systems are arranged in lamellar membrane stacks intercalated by DNA molecules. This is confirmed by 31P-NMR, where a superposition of an axially symmetric powder pattern arising from the phospholipid membr

We investigate theoretical models of room temperature ionic liquids, and find that the experimentally observed camel-shape of the differential capacitance is strongly related to dispersion interactions in these systems. At low surface charge densities, the loss of dispersion interactions in the vicinity of the electrodes generates depleted densities, with a concomitant drop of the differential cap

Different physicochemical properties and the chemical composition of soluble and insoluble fiber were studied. The influence of fiber source (apple, tomato, carrot and potato pulp), concentration and homogenization were investigated. The fiber suspensions respond in different ways to homogenization. This can, for most physicochemical properties investigated, be due to the fundamentally different m

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In clonal beta-cell lines and islets from different species, a variety of calcium channels are coupled to glucose-stimulated insulin secretion. The aim of this study was to identify the voltage-gated calcium channels that control insulin secretion in insulinoma (INS)-1 832/13 cells. The mRNA level of Ca(V)1.2 exceeded that of Ca(V)1.3 and Ca(V)2.3 two-fold. Insulin secretion, which rose tenfold in

The octahedral title complex, [PtI4(C2H6S)2] or trans PtI4(dms)2 (dms is dimethylsulfide), crystallizes in the monoclinic space group P21/n (Z=2) with molecular symmetry Ci, which is the most frequently occurring point group for trans-PtX4L2[56%, 28 structures in the Cambridge Structural Database (CSD) [Allen, 2002, Acta Cryst B58, 380-388]] followed by C1 (22%, 11 structures). The complexes form

A high intake of omega-3 polyunsaturated fatty acids (ω-3 PUFAs), has been associated with reduced levels of blood pressure (BP). Their antihypertensive action may be due to the reduction of the ω-6/ω-3 ratio and the resulting competitive effect of ω-3 as compared to arachidonic acid (an ω-6 PUFA) as a substrate of cytochrome P450 (CYP450) enzymes involved in the production of vasoactive mediators