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Linking clinical multi-omics with mechanistic studies may improve the understanding of rare cancers. We leverage two precision oncology programs to investigate rhabdomyosarcoma with FUS/EWSR1-TFCP2 fusions, an orphan malignancy without effective therapies. All tumors exhibit outlier ALK expression, partly accompanied by intragenic deletions and aberrant splicing resulting in ALK variants that are

Protoplanets growing within the protoplanetary disk by pebble accretion acquire hydrostatic gas envelopes. Due to accretion heating, the temperature in these envelopes can become high enough to sublimate refractory minerals which are the major components of the accreted pebbles. Here we study the sublimation of different mineral species and determine whether sublimation plays a role during the gro

Context. With data releases from the astrometric space mission Gaia, exploration of the structure of the Milky Way is now possible in unprecedented detail, and has unveiled many previously unknown structures in the Galactic disc and halo. One such feature is the Gaia phase spiral where the stars in the Galactic disc form a spiral density pattern in the Z- VZ plane. Many questions regarding the pha

Observed high spin states in 30Zn and 66Dy isotopes with two protons outside the closed shells at Z = 28 and Z = 64, respectively, are discussed and compared with cranked Nilsson-Strutinsky calculations. Bands terminating at higher and higher spin values are formed from successive proton excitations across these shells. These bands show very different features depending on the number of excited pa

The neutron rich 27Na was studied at Florida State University using the 14C(14C,p) reaction at 22 MeV. The 14C target was 0.28 mg/cm2 thick. γ-γ and particle-γ, coincidences were measured using 2 four-crystal clover detectors, 7 Compton-suppressed HPGe detectors, and a particle detector telescope at 0°. The 1757, 1823, and 2219 keV transitions are likely yrast transitions in 27Na. Based on systema

High spin states in 127La have been studied using the 32S(100Mo,p4n) reaction at a beam energy of 155 MeV. Gamma rays were detected using the EUROBALL III spectrometer. One of the side bands in 127La is observed to be populated to a spin of 83/2+. These data are compared with cranked Nilsson-Strutinski calculations which suggest that the structure is a smoothly terminating band, in valence space,

Excited states have been identified in the very neutron-deficient 119Ba nucleus. Two bands have been observed, which are likely to be based on h11/2 and (g7/2d5/2) neutron orbitals. Despite this being the first observation of excited states in 119Ba, the bands extend to (75/2)ℏ and (79/2)ℏ, respectively. The bands have been assigned to 119Ba using gamma-recoil and gamma-x-ray coincidences. Several

In atrial fibrillation (AF), the ECG P-wave, which represents atrial depolarization, is replaced with chaotic and irregular fibrillation waves (f waves). The f-wave frequency, F f, shows significant variations over time. Cardiorespiratory interactions regulated by the autonomic nervous system have been suggested to play a role in such variations. We conducted a simulation study to test whether t

Second harmonic generation is popular due to its numerous applications in different technologies dealing with multiple fields of science. The rapid technical advancement with the second harmonic generation demands parallel development in the theoretical understanding. With this view in mind, in our three papers, we theoretically investigated second harmonic generation from different systems in an

High-spin states in the near proton-dripline nucleus 107Sb have been identified, and collectivity in this nucleus has been observed for the first time in the form of two rotational bands. One of the observed rotational structures is a ΔI = 1 band, and is interpreted as based on a π(g9/2)-1 ⊗ π(g7/2d5/2)2 proton configuration. A second structure has ΔI = 2 character, and is explained as being based

High-spin states of 98,99,100Ru have been populated using the reaction 70Zn(36S, αxn) at 130 MeV. The γ rays have been detected with the EUROGAM-2 array. New high-spin bands have been established in these nuclei and interpreted as terminating configurations using the Nilsson-Strutinsky cranking formalism. These bands were observed up to the predicted terminating states which are built from g9/2 pr

Very high spin states (I=50-60ℏ) have been observed in the transitional nuclei 161Er and 162Er using the Euroball γ-ray spectrometer. In 161Er, three bands are observed well above spin 50ℏ. In the positive parity, positive signature (+, + 1/2) band a discontinuity in the regular rotational behavior occurs at 109/2+ and a splitting into two branches occurs at 97/2- in the negative parity, positive

Respublica Litteraria in Action: Travels--Maps--Itineraries, ed. Katarzyna Tomaszuk. Supplement: Patryk Sapała, The Itinerary of Bishop Piotr Tomicki, Vice-Chancellor of the Kingdom of Poland (1515-1535), Warsaw: University of Warsaw Press, 2023 (series: Corpus Epistularum Ioannis Dantisci, part V: Respublica Litteraria in Action, vol. 4).

This study is a close replication of Kanwit and Geeslin (2014), an investigation of the interpretation of verbal moods in adverbial clauses in Spanish. Whereas the first language of the second-language participants in the original study was English, we explore whether Kanwit and Geeslin’s results extend to other first-language populations—Swedish and French learners of Spanish. Participants in the

This paper presents a reconfigurable radio frequency front-end (RFFE) tailored for direct RF sampling receivers operating within Frequency Range 1 (FR-1) of the 5G spectrum. It consists of a balun-LNA, a noise-cancelling, current-reuse, Q-enhanced filter, and a programmable gain amplifier (PGA). Fabricated in 22-nm FD-SOI technology, the RFFE covers the entire frequency range from 1.7 to 6.4 GHz w