Background: Obesity induces molecular changes that may favor tumor progression and metastatic spread, leading to impaired survival outcomes in breast cancer. Adenylate cyclase-associated protein 1 (CAP1), an actin regulatory protein and functional receptor for the obesity-associated adipokine resistin, has been implicated with inferior cancer prognosis. Here, the objective was to investigate the i

Monarch butterflies (Danaus plexippus) are prominent for their annual long-distance migration from North America to their overwintering area in Central Mexico. To find their way on this long journey, they use a sun compass as their main orientation reference but will also adjust their migratory direction with respect to mountain ranges. This indicates that the migratory butterflies also attend to

Outcome prognostication after cardiac arrest (CA) is challenging. Current multimodal prediction approaches would benefit from new biomarkers. MicroRNAs constitute a novel class of disease markers and circulating levels of brain-enriched ones have been associated with outcome after CA. To determine whether these levels reflect the extent of brain damage in CA patients, we assessed their correlation

Den klädda kroppens identiteter och förvandlingar lockar i modets metamorfoser en read nordiska akademiska skribenter att skriva om kläder, mode, kropp; om kläder mode och plats liksom om mode och makt. Tanken med boken är att överbrygga den polarisering som ibland görs mellan kläder och mode, men också studera kulturella processer om hur identitet kan baseras på något materiellt som just plagg.

Background: Women with idiopathic pulmonary arterial hypertension (IPAH) have been found to have a worse haemodynamic status at diagnosis, but better survival than men. Over the past decade, demographics have changed and new treatments have become available. The objective of this study was to investigate sex differences in an incident IPAH population diagnosed between 2008 and 2016.Methods: Differ

Outpatient pulmonary hypertension (PH) specialist centers have an important role in the optimal management of pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH). The aim of the present study was to gain an understanding of the work facing nurses at the outpatient PH specialist centers in Sweden. All nurses (n = 14) working at the outpatient PH specialis

Objective: Segmentation is one way of improving data protection. The aim of this study was to investigate Information Technology (IT) and Medical Technology (MT) personnel's perception in relation to ongoing segmentation of medical devices and IT infrastructure in the healthcare sector. Methods: Focus group interviews with 9 IT and 9 MT personnel in a county council in southern Sweden were conduct

Lately, the idea of ‘non-toxic’ (or ‘clean’) material cycles has become increasingly popular as a starting point for the consideration of circular economy strategies among leading regulating actors, such as the European Commission (2017). However, it should be apparent that, by default, circular economy aspirations awaken a potential policy conflict between increased circulation of resources and r

Background: This article is based on a common understanding of the concept of creative activities as intervention, as described in occupational therapy literature. Historically, creative activities have been used as intervention in occupational therapy. There is, however, a lack of clarity in descriptions of the concept. Aims/Objectives: To investigate and clarify the concept of creative activitie

Background: Emergency Department (ED) crowding occurs when demand for care exceeds the available resources. Crowding has been associated with decreased quality of care and increased mortality, but the prevalence on a national level is unknown in most countries. Method: We performed a national, cross-sectional study on staffing levels, staff workload, occupancy rate and patients waiting for an in-h

Background: Inferior placement of a femoral stem is predictive for early loosening and failure, but does restoration of the original hip anatomy benefit the function and survival of a total hip replacement? Methods: Seventy-five patients with primary unilateral hip osteoarthritis operated with an uncemented anatomical stem were randomized for either standard or modular stems. We used 50 ABG II ste

Open Source receives high attention among organizations today, and there is also a growing interest on Open Source Enterprise Resource Planning (OS ERP) systems. Open source development is often considered having a high level of involvement from stakeholders in adopting organizations. However, it depends on for the first what is meant by stakeholders, but also what is meant by involvement. In the

We study the formation rate of binary black hole mergers formed through gravitational-wave emission between unbound, single black holes in globular clusters. While the formation of these binaries in very dense systems such as galactic nuclei has been well studied, we show here that this process can operate in lower-density stellar systems as well, forming binaries at a rate similar to other propos

DNA methylation changes during aging, but it remains unclear whether the effect of DNA methylation on lung cancer survival varies with age. Such an effect could decrease prediction accuracy and treatment efficacy. We performed a methylation-age interaction analysis using 1,230 early-stage lung adenocarcinoma patients from five cohorts. A Cox proportional hazards model was used to investigate lung

When subjecting cast irons to mechanical loading the deformation and damage mechanisms occur on a microstructural level and are dependent on the inherent microstructure. A deeper understanding of the relation between the different microstructural constituents and the macroscopic mechanical behaviour would be beneficial in material development efforts and for the ability to design and cast componen

While largely studied in the macroscopic scale, the dynamics leading to the nucleation and fission of atmospheric aerosols are very poorly understood at the nano or molecular scale. A model system consisting on ionized hydrogen-bonded ammonia and water molecules have been studied experimentally using mass- and 3D momentum spectroscopy and theoretically using ab initio molecular dynamics simulation