Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) potently augment insulin response to glucose. It is less known what their effects are insulin clearance, which also contributes to peripheral hyperinsulinemia observed after administration of incretins together with glucose. The aims of this study were the quantification of C-peptide secretion and the evaluation

Lead has negative effect on cognitive functions in children. However, individuals differ in susceptibility. One possible explanation is a genetic predisposition. Polymorphisms in the B-aminolevulinic acid dehydratase (ALAD) and the vitamin D receptor (VDR) genes may modify lead metabolism and neurotoxicity, but information regarding the central nervous system is very limited. The aim of the study

Several notions of a R&D paradox can be found in the literature. In the Swedish Paradox version, the emphasis is normally on high and growing levels of business R&D connected to comparatively low GDP growth rates. This paper examines whether this pattern is consistent over time and, more importantly, which sectors drive the aggregate patterns. Based on an investigation of the entire Swedis

To estimate the effects of smoking, gender and occupational exposure on the risk of developing severe pulmonary fibrosis (PF), including dose-response and interaction effects.

This paper presents a pilot study in which specific activities of (14)C in hair and urine from 11 radiation workers handling (14)C-containing substances have been measured using accelerator mass spectrometry. Varying degrees of contamination were revealed: up to 63% excess in hair and 400% excess in urine. Although the (14)C excess reported in this study would result in low effective doses, it wou

Popular Abstract in Icelandic SUMMARY IN ICELANDIC Samantekt á íslensku Hlutfall eldra fólks í Evrópu sem og annars staðar í heiminum hefur aukist og þá sérstaklega þeirra sem eru 80 ára og eldri. Vegna hrumleika og langvinnra sjúkdóma er líklegt að þessi aldurshópur þarfnist aðstoðar frá hinu opinbera, m. a. vistunar á hjúkrunarheimilum. Því má ætla að á komandi árum muni hjúkrunarheimilin standThe overall aim of this thesis was to investigate trends over time in residents’ health status, functional profile and predictors of mortality at admission to Icelandic nursing homes and in addition to determine upper and lower thresholds for Minimum Data Set (MDS) Quality Indicators, to investigate the prevalence of quality indicators over time and their association with the health status and fun

The aim of this dissertation is to examine how differences in socioeconomic status, race and place of residence interact with infant and child mortality in Colombia over the period 1967-2010. One of the reasons why the study focuses on infant and child mortality is that the living conditions of children are outside their control, and therefore a good measure of inequality of opportunity. This stud

Capsule Resident Blackcaps in eastern Spain differ in morphology and isotope profile from central European conspecifics wintering in the area, but not from locally breeding migrants. Aims Natural selection shapes flight morphology in relation to migratory habits. Thus, intraspecific variation in migratory behaviour is often paralleled by morphological differentiation. We test whether differences i

Reaction of [Ru-3(CO)(12)] with tri(2-furyl)phosphine, P(C4H3O)(3), at 40 degrees C in the presence of a catalytic amount of Na[Ph2CO] furnishes two triruthenium complexes [Ru-3(CO)(10){P(C4H3O)(3)}(2)] (1) and [Ru-3(CO)(9){P(C4H3O)(3)}(3)] (2) with the ligand coordinated through the phosphorus atom. Treatment of 1 and 2 with Me3NO at 40 degrees C affords the dinuclear phosphido-bridged complexes

Background: Risk gene variants for celiac disease, identified in genome-wide linkage and association studies, might influence molecular pathways important for disease development. The aim was to examine expression levels of potential risk genes close to these variants in the small intestine and peripheral blood and also to test if the non-coding variants affect nearby gene expression levels in chi

This article discuss the consequences of the ambiguous view of children in the ethical guidelines – the ambitions to “give voice” while also “protect” – with a point of departure taken in the Swedish context, and in an actual research process of a project on children and care. It shows how the regulation of informed consent through the parent compromises the ideals of child-centred research; first

Single complex fluorescence polarization spectroscopy is applied to study the peripheral light harvesting antenna (LH2) from photosynthetic purple bacterium Rhodopseudomonas (Rps.) acidophila. The measured two-dimensional excitation-emission polarization plots are used to construct geometric representation for the absorbing B800 and emitting B850 as ellipses. The shape and orientation of the ellip

Background: Rehabilitation is effective and beneficial for patients with arthritis. The lack of a common structure for describing the content of rehabilitation makes it difficult to compare, transfer and implement research evidence into clinical practice. Objective: To develop a framework comprising domains and elements of importance when describing arthritis rehabilitation. Methods: On the basis

Book review

An improved, chemoselective hydrogenolysis method has been developed. By employing a solvent-acid combination (i.e., DMF-aq HCl) we were able to favor debenzylation rather than aromatic hydrogenation and acid-mediated bond cleavage which are the two main drawbacks of these reactions. The generality of the method, which was primarily developed as a solution to a carbohydrate problem, is shown by th

Hemoglobin (Hb) plays a critical role in human physiological function by transporting O-2. Hb is safe and inert within the confinement of the red blood cell but becomes reactive and toxic upon hemolysis. Haptoglobin (Hp) is an acute-phase serum protein that scavenges Hb and the resulting Hb-Hp complex is subjected to CD163-mediated endocytosis by macrophages. The interaction between Hb and Hp is e

The formation of planets with gaseous envelopes takes place in protoplanetary accretion discs on time scales of several million years. Small dust particles stick to each other to form pebbles, pebbles concentrate in the turbulent flow to form planetesimals and planetary embryos and grow to planets, which undergo substantial radial migration. All these processes are influenced by the underlying str