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MICRODOSING FOR EARLY BIOKINETIC STUDIES IN HUMANS.

Microdosing is a new concept in drug development that-if implemented in the pharmaceutical industry-would mean that new drugs can be tested earlier in humans than done today. The human microdosing concept-or 'Phase 0'-may offer improved candidate selection, reduced failure rates in the drug development line and a reduction in the use of laboratory animals in early drug development, factors which w

Malmös omvandling: från arbetarstad till kunskapsstad : En diskursanalytisk studie av Malmös förnyelse

Popular Abstract in SwedishMed utgångspunkt i två forskningsfält – strategisk kommunikation och urbanforskning – analyseras och problematiseras Malmös omvandling från arbetarstad till kunskapsstad. Hur har Malmös förändring genomdrivits? Vilka resonemang och föreställningsramar har styrt omvandlingen? Vilka kommunikativa strategier har använts för att projicera den önskvärda (själv)bilden av en kuIncreasingly cities compete for tourist dollars, shoppers, financial investments, know-how and tax-payers by bolstering the cities images as centers of creativity, innovation, knowledge, art, design and so forth. Accelerated and intensified globalization, technological advances, market deregulations,de-industrializations and socio-economic change have urged cities, especially former industrial cit

Signs of fetal brain sparing are not related to umbilical cord blood gases at birth.

BACKGROUND: Fetal chronic hypoxia leads to centralization of circulation in order to spare the vital organs brain, adrenals and the heart. This can be documented by Doppler ultrasound. Increased blood velocity in the fetal middle cerebral artery (MCA) is an acknowledged sign of centralization of circulation in chronic hypoxia, and is called brain sparing. AIM: Our aim was to assess the relationshi

Minimal and canonical rational generator matrices for convolutional codes

A full-rank IC x n matrix G(D) over the rational functions F(D) generates a rate R = k/n convolutional code C. G(D) is minimal if it can be realized with as few memory elements as any encoder for C, and G(D) is canonical if it has a minimal realization in controller canonical form. We show that G(D) is minimal if and only if for all rational input sequences p1 (D), the span of U (D) G (D) covers t

Dc-resistometric Urea Sensitive Device Utilizing A Conducting Polymer Film For the Gas-phase Detection of Ammonia

The construction of an urea sensitive device based on a conducting polymer is described. The conducting polymer (polypyrrole) was exposed only to a gas-phase; this led to a significant improvement in its stability. A DC-resistometric measuring principle was used, which required only simple measuring equipment. The device responded rapidly to between 0 and 500 mM urea, with resistance changes of be