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While smoking is a well-established risk factor for pancreatic cancer, the effect of smokeless tobacco is less well understood. We used pooled individual data from the Swedish Collaboration on Health Effects of Snus Use to assess the association between Swedish snus use and the risk of pancreatic cancer. A total of 424,152 male participants from nine cohort studies were followed up for risk of pan

Background: PSP is a neuropathologically defined disease entity. Clinical diagnostic criteria, published in 1996 by the National Institute of Neurological Disorders and Stroke/Society for PSP, have excellent specificity, but their sensitivity is limited for variant PSP syndromes with presentations other than Richardson's syndrome. Objective: We aimed to provide an evidence- and consensus-based rev

The received wisdom has long been that people in Europe reacted with great enthusiasm as war was approaching in August, 1914. However, scholars who have investigated the matter have found little evidence of enthusiasm. There was no unique “spirit of 1914,” and people in general were not happy about the prospect of war. This revisionist thesis is now the new orthodoxy and should as such be subject The received wisdom has long been that people in Europe reacted with great enthusiasm as war was approaching in August, 1914. However, scholars who have investigated the matter have found little evidence of enthusiasm. There was no unique “spirit of 1914,” and people in general were not happy about the prospect of war. This revisionist thesis is now the new orthodoxy and should as such be subject

Today, there is an increased realization that engaging with Paralympic athletes offers the chance for healthcare professionals to work at the intersection of rehabilitation with sports and exercise medicine. The study of both injury and illness epidemiology in Paralympic sport is important, as findings may assist in the formulation of prevention strategies. A model for the systematic development o

Background: In order to contain public health care spending, European countries attempt to promote informal caregiving. However, such a cost reducing strategy will only be successful if informal caregiving is a substitute for formal health care services. We therefore analyze the effect of informal caregiving for people with dementia on the use of several formal health care services. Study design:

In order to explore consumer culture’s potential to change social relations, this investigation immerses into the growing consumer culture of foodies occupying the historically feminine space of domestic cooking. It offers a tentative theory on the entering of subordinate consumption fields in contexts where the entering is sanctioned by cultural authorities.

Co-presentation with both ANCA and anti-GBM antibodies is thought to be relatively rare. Current studies of such 'double-positive' cases report small numbers and variable outcomes. To study this further we retrospectively analyzed clinical features and long-term outcomes of a large cohort of 568 contemporary patients with ANCA-associated vasculitis, 41 patients with anti-GBM disease, and 37 double

The focus of this thesis is the life and death of adult retinal ganglion cells (RGCs). RGCs are neurons that convey visual information from the retina to higher centers in the brain. If the optic nerve is transected (ONT), adult RGCs die by a form of cell death called apoptosis, and a general hypothesis is that neurotrophic factors can support the survival of injured neurons.With the intention to The focus of this thesis is the life and death of adult retinal ganglion cells (RGCs). RGCs are neurons that convey visual information from the retina to higher centers in the brain. If the optic nerve is transected (ONT), adult RGCs die by a form of cell death called apoptosis, and a general hypothesis is that neurotrophic factors can support the survival of injured neurons. With the intention to

Myeloid cells play a central role in atherosclerosis. We investigated the associations between the plasma levels of growth factors and chemokines that regulate myeloid cell homeostasis and function and the risk of first-time acute coronary events in middle-aged persons. Methods and Results-We measured baseline plasma levels of macrophage colony-stimulating factor monocyte chemotactic protein 1; C-

This is an overview paper that motivates and describes performed work done in the European Commission funded research project BASTION, which focuses on two critical problems of modern electronics: the No-Fault-Found (NFF) and CMOS ageing. New defect classes contributing to NFF have been identified, including timing related faults (TRF) at board level and intermittent resistive faults (IRF) at IC l

Scholars and policy makers consider knowledge accumulation a major driver of growth and regional development. During the past two decades, the geography of innovation literature has provided a rich and detailed account of the underlying processes of regional knowledge production. More recently, a growing body of empirical literature has analysed the specific knowledge bases of regions and their ev

The retina is a thin tissue layer on the inside of the eye and may be subject to tractional forces in diseases like myopia, retinoschisis, and retinal detachment. Müller glial cells (MGCs) are the only cells spanning the entire retinal thickness and hypothetically respond to mechanical stress imposed across retinal layers. We designed a device to apply force in vitro perpendicular to the retinal sThe retina is a thin tissue layer on the inside of the eye and may be subject to tractional forces in diseases like myopia, retinoschisis, and retinal detachment. Müller glial cells (MGCs) are the only cells spanning the entire retinal thickness and hypothetically respond to mechanical stress imposed across retinal layers. We designed a device to apply force in vitro perpendicular to the retinal s

Identification of metabolites in non-targeted metabolomics continues to be a bottleneck in metabolomics studies in large human cohorts. Unidentified metabolites frequently emerge in the results of association studies linking metabolite levels to, for example, clinical phenotypes. For further analyses these unknown metabolites must be identified. Current approaches utilize chemical information, suc

Introduction In the context of public transportation, just as in many parts of society, the level of organizational complexity has increased over the last twenty years. Due to structural reforms and policy adjustments, responsibilities for the public transportation system in Sweden have become increasingly divided between a variety of public and private actors, thus fragmenting the organizational